In search of the ratio of miRNA expression as robust biomarkers for constructing stable diagnostic models among multi-center data
Cuidie Ma,
Yonghao Zhang,
Rui Ding
et al.
Abstract:MicroRNAs (miRNAs) are promising biomarkers for the early detection of disease, and many miRNA-based diagnostic models have been constructed to distinguish patients and healthy individuals. To thoroughly utilize the miRNA-profiling data across different sequencing platforms or multiple centers, the models accounting the batch effects were demanded for the generalization of medical application. We conducted transcription factor (TF)-mediated miRNA–miRNA interaction network analysis and adopted the within-sample… Show more
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