In search of mechanisms to explain the unquestionable benefit derived from sodium-glucose cotransporter-2 (SGLT-2) inhibitors use in heart failure patients

López‐Candales, Angel; Sawalha, Khalid; Drees, Betty M.; Norgard, Nicholas B

doi:10.1080/00325481.2023.2181537

Cited by 1 publication

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…78,85,94 Numerous clinical studies have demonstrated that sodium-dependent glucose transporters 2 inhibitor is beneficial for patients with CVDs, such as HF and diabetic cardiomyopathy (DCM), and is closely related to mitochondrial LPO. 90,95,96 Although the studies covered in this article reflect a close link between ferroptosis and mitochondria, the relationship between the 2 has been controversial. It was found that although the target of erastin, VADC, is located in the mitochondria, there was no significant increase in mitochondrial ROS in erastin-treated cells, and no ferroptosis occurred in subsequent experiments.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ferroptosis Involved in Cardiovascular Diseases: Mechanism Exploration of Ferroptosis' Role in Common Pathological Changes

Gao,

Hu,

et al. 2023

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

Regulated cell death is a controlled form of cell death that protects cells by adaptive responses in pathophysiological states. Ferroptosis has been identified as a novel method of controlling cell death in recent years. Several cardiovascular diseases (CVDs) are shown to be profoundly influenced by ferroptosis, and ferroptosis is directly linked to the majority of cardiovascular pathological alterations. Despite this, it is still unclear how ferroptosis affects the pathogenic alterations that take place in CVDs. Based on a review of the mechanisms that regulate ferroptosis, this paper explores the most recent research on the role of ferroptosis in the major pathological changes associated with CVDs, in order to provide new perspectives and strategies for cardiovascular research and clinical treatment.

show abstract