In Search of Feasible Interventions for the Prevention and Cure of Novel Coronavirus Disease 2019&lt;strong&gt; &lt;/strong&gt;

Verma, Sunil Kumar

doi:10.20944/preprints202003.0353.v1

Cited by 2 publications

(3 citation statements)

References 33 publications

(44 reference statements)

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“…It exhibits several pharmacologic properties, such as antioxidant, antiinflammatory, and antifibrotic properties. It is important to note that not all the analogs are the same, and their stability and efficacy are dose-dependent and related to a specific type [15][16][17].…”

Section: Curcumin (Curcuma Longa)mentioning

confidence: 99%

“…The turmeric-derived polyphenol curcumin has been tested for therapeutic potential against SARS-CoV-2 (based on potential anti-HIV activity due to HIV-1 or HIV-2 protease inhibitor and HIV-1 integrase inhibitor activities, possible inhibition of SARS-CoV-2 has been suggested). It has also been shown that Zika and chikungunya virus incubated with curcumin lose their infectivity [16]. The potential mechanism of action relies on the reduction of the protein level of the Ang II type 1 (AT1) receptor and upregulation of the Ang II type 2 (AT2) receptor, evidenced by an increased ratio of AT2 receptor to AT1 receptor in the curcumin group (1.2 ± 0.02%) vs. the Ang II group (0.7 ± 0.03%, p = 0.05).…”

Section: Curcumin (Curcuma Longa)mentioning

confidence: 99%

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Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits

2021

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The trend toward using phytonutrients and/or nutraceuticals (P/Ns) with the aim of impacting immune health has increased in recent years. The main reason is that properties of P/Ns are associated with possible immunomodulating effects in the prevention and complementary treatment of viral diseases, including COVID-19 and other respiratory infections. In the present review, we assess the scientific plausibility of specific P/Ns for this purpose of preventative and therapeutic interventions against COVID-19, with an emphasis on safety, validity, and evidence of efficacy against other viruses. Five potential candidates have been identified after reviewing available studies (in silico, in vitro, and in vivo) in which certain flavonoids have demonstrated a potential for use as adjuvant therapeutic agents against viral infections, including COVID-19. As these are often better tolerated than pharmacological treatments, their use could be more widely considered if additional detailed studies can validate the existing evidence.

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Section: Curcumin (Curcuma Longa)mentioning

confidence: 99%

Section: Curcumin (Curcuma Longa)mentioning

confidence: 99%

Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits

2021

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“…Sheng Mai Injection, Gong Niu Huang Pill, Shen Mai Injection, Shen Fu Injection, and a Su He Xiang Pill are also used in patients in critical condition. Some other medicinal herbs suggesting to test in order to prevent and treatment of COVID-19 are dried rhizome of Curcuma longa L. This herb has antiviral activities against herpes simplex virus and HIV, therefore, it can also have inhibitory effects in terms of SARS-CoV-2 entry into the host cell (125).…”

Section: Effective Natural Herbsmentioning

confidence: 99%

Epidemiology, virology, clinical features, diagnosis, and treatment of SARS-CoV-2 infection

Baghi¹,

Jafari-Sales²,

Nasiri³

et al. 2021

J Exp Clin Med

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Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged and spread quickly worldwide. The disease is generally mild in adult people but in any with comorbidities may proceed to acute respiratory distress syndrome (ARDS), pneumonia, and multi-organ dysfunction. By performing molecular tests on respiratory secretions can diagnose the virus. Elevated C-reactive protein (CRP) and normal/low white cell counts are common laboratory diagnoses of COVID-19 while the tomographic chest scan is usually irregular for many infected people. Some patients progress to respiratory failure, pneumonia, and finally death by the end of the first week of illness because of the sharp rise in inflammatory cytokines such as IL7, IL2, GCSF, IL10, MIP1A, MCP1, IP10, and TNFα. Various approaches to the COVID- 19 are being performed by scientists. Use of chemical medical drugs that are effective for other viral infections. Among them, remdesivir was approved by FDA on 1th May 2020 because of its impact to treat patients. Also, several studies have revealed that many Chinese herbal remedies have a remarkable impact on the healing process when simultaneously were used along with pharmacological drugs. In the meantime, many efforts have been made to produce an effective vaccine, and so far, the Ad5-vectored COVID-19 vaccine has been successful and has entered phase 2 in the human trial. The current review focus on epidemiology, virology, clinical features, diagnosis, and available treatment of coronavirus that might assist researchers and clinicians in establishing action options for timely against this infection.

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In Search of Feasible Interventions for the Prevention and Cure of Novel Coronavirus Disease 2019<strong> </strong>

Cited by 2 publications

References 33 publications

Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits

Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits

Epidemiology, virology, clinical features, diagnosis, and treatment of SARS-CoV-2 infection

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