In search of autobiographical memories: A PET study in the frontal variant of frontotemporal dementia

Piolino, Pascale; Chételat, Gaël; Matuszewski, Vanessa; Landeau, Brigitte; Mézenge, Florence; Viader, Fausto; Sayette, Vincent de La; Eustache, Francis; Desgranges, Béatrice

doi:10.1016/j.neuropsychologia.2007.04.013

Cited by 66 publications

(40 citation statements)

References 104 publications

(119 reference statements)

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“…For example, using a process dissociation procedure that separates automatic and controlled processes in memory, Collette, Van der Linden, and Salmon (2010) found that bvFTD were impaired on controlled but not automatic processes during a cued-recall task when compared to controls. Several studies have shown that autobiographical memory in bvFTD is impaired irrespective of the particular time period of the memory (i.e., lack of a temporal gradient; Irish, et al, 2011;Matuszewski, et al, 2006;Piolino, et al, 2007;Piolino, et al, 2003), suggesting a specific difficulty in memory retrieval rather than encoding. Simons et al (2002;exp. 3) observed that bvFTD patients, compared to controls, were disproportionately impaired on source memory versus item recognition, and that source memory performance in bvFTD was correlated with performance on a composite score of frontal function.…”

Section: Emotion In Frontotemporal Dementia 17mentioning

confidence: 99%

Emotional evaluation and memory in behavioral variant frontotemporal dementia

Jacques¹,

Grady²,

Davidson³

et al. 2014

Neurocase

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Behavioral variant frontotemporal dementia (bvFTD) affects emotional evaluation, but less is known regarding patients' ability to remember emotional stimuli. (ere, bvFTD patients and age-matched controls studied positive, negative and neutral pictures followed by a recognition memory test. Compared to controls, bvFTD patients showed a reduction in emotional evaluation of negative scenes, but not of positive or neutral scenes. Additionally, the patients showed an overall reduction in recognition memory accuracy, due to impaired recollection in the face of relatively preserved familiarity. These results show that bvFTD reduces emotional evaluation of negative scenes and impairs overall recognition memory accuracy and recollection.

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Section: Emotion In Frontotemporal Dementia 17mentioning

confidence: 99%

Emotional evaluation and memory in behavioral variant frontotemporal dementia

Jacques¹,

Grady²,

Davidson³

et al. 2014

Neurocase

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“…Increased connectivity among lateral temporal areas has been detected during the recognition of general knowledge and public events (Maguire et al, 2000), both semantic in nature, suggesting a role of these regions in semantic processes. In fact, evidence has linked the functions of the lateral temporal lobes to personal semantic memory processes (Mummery et al, 1996;Lee et al, 2002;Piolino et al, 2007; for review, see Svoboda et al, 2006). It has been hypothesized that the temporal pole acts as a convergence zone and integrates information from hippocampal structures and posterior association regions (Damasio, 1989;Maguire et al, 2000;Svoboda et al, 2006).…”

Section: Correlations Between Activation In Extra-mtl Neocortical Regmentioning

confidence: 99%

“…Posterior regions, such as the precuneus or the posterior cingulate gyrus, have been associated with access to sensory-perceptual details, in particular via their role in mental visual imagery (Fletcher et al, 1995;Cavanna and Trimble, 2006). Lateral temporal activations are involved in semantic retrieval processes (Maguire, 2001;Piolino et al, 2007). Indeed, autobiographical retrieval is often initiated by first browsing through the general levels of autobiographical knowledge before accessing an episodic event (Conway and Pleydell-Pearce, 2000;Conway et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Patterns of hippocampal–neocortical interactions in the retrieval of episodic autobiographical memories across the entire life‐span of aged adults

Viard¹,

Lebreton²,

Chételat³

et al. 2009

Hippocampus

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We previously demonstrated that episodic autobiographical memories (EAMs) rely on a network of brain regions comprising the medial temporal lobe (MTL) and distributed neocortical regions regardless of their remoteness. The findings supported the model of memory consolidation, which proposes a permanent role of MTL during EAM retrieval (multiple-trace theory or MTT) rather than a temporary role (standard model). Our present aim was to expand the results by examining the interactions between the MTL and neocortical regions (or MTL-neocortical links) during EAM retrieval with varying retention intervals. We used an experimental paradigm specially designed to engage aged participants in the recollection of EAMs, extracted from five different time-periods, covering their whole life-span, in order to examine correlations between activation in the MTL and neocortical regions. The nature of the memories was checked at debriefing by means of behavioral measures to control the degree of episodicity and properties of memories. Targeted correlational analyses carried out on the MTL, frontal, lateral temporal, and posterior regions revealed strong links between the MTL and neocortex during the retrieval of both recent and remote EAMs, challenging the standard model of memory consolidation and supporting MTT instead. Further confirmation was given by results showing that activation in the left and right hippocampi significantly correlated during the retrieval of both recent and remote memories. Correlations among extra-MTL neocortical regions also emerged for all time-periods, confirming the critical role of the prefrontal, temporal (lateral temporal cortex and temporal pole), precuneus, and posterior cingulate regions in EAM retrieval. Overall, this paper emphasizes the role of a bilateral network of MTL and neocortical areas whose activation correlate during the recollection of rich phenomenological recent and remote EAMs.

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“…Diagnoses were also supported by structural and/or functional imaging (SPECT). Some of these patients have already been described in previous investigations [16,40,51]. We also studied a group of 18 healthy elderly subjects, selected to match the fv-FTD and SD patients in terms of age, sex and education level.…”

Section: Subjectsmentioning

confidence: 99%

“…Voxel-based mapping of the correlations between cognitive performances and resting-state FDG uptake is a sensitive approach to delineating the neural substrates of cognitive impairment (for a detailed discussion, see [17]). This method has successfully been used in Alzheimer's disease [14,15,18,26,34,57], but only rarely in fv-FTD [51] and never, to the best of our knowledge, in SD.…”

Section: Introductionmentioning

confidence: 99%

The underlying mechanisms of verbal fluency deficit in frontotemporal dementia and semantic dementia

et al. 2009

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Verbal fluency tasks are commonly used to explore semantic memory and executive functions. The aim of this study was to gain a better understanding of the cognitive and neural mechanisms underlying verbal fluency impairment in the frontal variant of frontotemporal dementia (fv-FTD) and in semantic dementia (SD). Semantic and phonemic fluency tasks were performed by 36 fv-FTD and SD patients and 18 elderly controls. We also carried out a neuropsychological investigation of semantic memory, working memory and shifting and updating processes. We performed correlative and regression analyses of fluency scores and neuropsychological data. In addition, patients underwent a resting positron emission tomography examination, and statistical parametric mapping was used to establish correlations between resting-state FDG uptake in the whole brain and fluency scores for each patient group. Both patient groups displayed impaired performances on both fluency tasks compared with controls, but with different patterns. While fv-FTD patients scored higher than SD patients on semantic fluency, their performances on the phonemic task did not differ. Correlation and regression analyses clearly demonstrated that the fv-FTD patients' performances on both fluency tasks depended on their executive abilities, while those of the SD patients were hampered by the impairment of their semantic memory store. Correlations with resting FDG uptake were consistent with the results of the cognitive study. In fv-FTD, both fluency performances were related to the metabolism of the frontal lobes, while we observed significant correlations between performances on both fluency tasks and the left temporal lobe metabolism in SD.

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In search of autobiographical memories: A PET study in the frontal variant of frontotemporal dementia

Cited by 66 publications

References 104 publications

Emotional evaluation and memory in behavioral variant frontotemporal dementia

Emotional evaluation and memory in behavioral variant frontotemporal dementia

Patterns of hippocampal–neocortical interactions in the retrieval of episodic autobiographical memories across the entire life‐span of aged adults

The underlying mechanisms of verbal fluency deficit in frontotemporal dementia and semantic dementia

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