In Search for the Membrane Regulators of Archaea

Salvador-Castell, Marta; Tourte, Maxime; Oger, Philippe

doi:10.3390/ijms20184434

Cited by 38 publications

(49 citation statements)

References 174 publications

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“…The role of HHP in modifying membrane characteristics, and the possible adaptive strategies to counteract it, have been particularly investigated in the field of extremophiles [28][29][30] . Piezophiles, i.e.…”

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confidence: 99%

Alkanes increase the stability of early life membrane models under extreme pressure and temperature conditions

et al. 2021

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Terrestrial life appeared on our planet within a time window of [4.4–3.5] billion years ago. During that time, it is suggested that the first proto-cellular forms developed in the surrounding of deep-sea hydrothermal vents, oceanic crust fractures that are still present nowadays. However, these environments are characterized by extreme temperature and pressure conditions that question the early membrane compartment’s capability to endure a stable structural state. Recent studies proposed an adaptive strategy employed by present-day extremophiles: the use of apolar molecules as structural membrane components in order to tune the bilayer dynamic response when needed. Here we extend this hypothesis on early life protomembrane models, using linear and branched alkanes as apolar stabilizing molecules of prebiotic relevance. The structural ordering and chain dynamics of these systems have been investigated as a function of temperature and pressure. We found that both types of alkanes studied, even the simplest linear ones, impact highly the multilamellar vesicle ordering and chain dynamics. Our data show that alkane-enriched membranes have a lower multilamellar vesicle swelling induced by the temperature increase and are significantly less affected by pressure variation as compared to alkane-free samples, suggesting a possible survival strategy for the first living forms.

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confidence: 99%

Alkanes increase the stability of early life membrane models under extreme pressure and temperature conditions

et al. 2021

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“…This can be due to the fact that long-chain polyisoprenoids are correlated to bilayer and not monolayer, which Sulfolobus membrane is mainly comprised of due to the high tetraether lipid content. In the bilayer, this polyterpene acts as a membrane stabilizer towards stress factors [76].…”

Section: Membrane Regulatorsmentioning

confidence: 99%

The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications

Rastädter

Wurm

Spadiut

et al. 2020

IJMS

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The microbial cell membrane is affected by physicochemical parameters, such as temperature and pH, but also by the specific growth rate of the host organism. Homeoviscous adaption describes the process of maintaining membrane fluidity and permeability throughout these environmental changes. Archaea, and thereby, Sulfolobus spp. exhibit a unique lipid composition of ether lipids, which are altered in regard to the ratio of diether to tetraether lipids, number of cyclopentane rings and type of head groups, as a coping mechanism against environmental changes. The main biotechnological application of the membrane lipids of Sulfolobus spp. are so called archaeosomes. Archaeosomes are liposomes which are fully or partly generated from archaeal lipids and harbor the potential to be used as drug delivery systems for vaccines, proteins, peptides and nucleic acids. This review summarizes the influence of environmental parameters on the cell membrane of Sulfolobus spp. and the biotechnological applications of their membrane lipids.

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“…Acidophilic microorganisms can survive under extremely low pH (less than pH 3) conditions, maintaining pH homeostasis by controlling proton permeation [ 19 ]. For example, microorganisms from the genera Thermoplasma , Ferroplasma, and Sulfolobus can regulate proton permeation under extremely low pH conditions due to a highly impermeable cell membrane mainly composed of tetraether lipids having a diverse array of polar head groups and a bulky isoprenoid core [ 20 , 21 , 22 , 23 ]. The modulation of the influx of protons through the proton pump system is important to survive at low pH, and putative proton pump proteins such as H + -ATPase, symporters, and antiporters from Ferroplasma type II and Leptospirillium group II are involved in maintaining pH homeostasis [ 21 , 24 , 25 ].…”

Section: Survival Strategies Of Extremophilic Microorganisms Undermentioning

confidence: 99%

Extremophilic Microorganisms for the Treatment of Toxic Pollutants in the Environment

Jeong

Choi

2020

Molecules

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As concerns about the substantial effect of various hazardous toxic pollutants on the environment and public health are increasing, the development of effective and sustainable treatment methods is urgently needed. In particular, the remediation of toxic components such as radioactive waste, toxic heavy metals, and other harmful substances under extreme conditions is quite difficult due to their restricted accessibility. Thus, novel treatment methods for the removal of toxic pollutants using extremophilic microorganisms that can thrive under extreme conditions have been investigated during the past several decades. In this review, recent trends in bioremediation using extremophilic microorganisms and related approaches to develop them are reviewed, with relevant examples and perspectives.

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In Search for the Membrane Regulators of Archaea

Cited by 38 publications

References 174 publications

Alkanes increase the stability of early life membrane models under extreme pressure and temperature conditions

Alkanes increase the stability of early life membrane models under extreme pressure and temperature conditions

The Cell Membrane of Sulfolobus spp.—Homeoviscous Adaption and Biotechnological Applications

Extremophilic Microorganisms for the Treatment of Toxic Pollutants in the Environment

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