In Response to Mamo et al. Noninvasive Ventilation After Thoracoabdominal Aortic Surgery: Is the Prevention of Postoperative Pulmonary Complications Rock-solid?

In Response to Karim et al: Noninvasive Ventilation After Thoracoabdominal Aortic Surgery: More Trials? Yes, Please

“…We thank Karim et al 1 for their interest in our recent publication 2 in the journal, which describes noninvasive ventilation (NIV) as a promising tool to prevent postoperative respiratory complications after open thoracoabdominal aortic aneurysm (TAAA) surgical repair. 3 Understanding NIV is fundamental to appreciate our findings; patients assigned to NIV received 2-hour cycles of continuous positive airway pressure with a positive end-expiratory pressure of 7.5 cmH 2 O.…”

“…We have read with great interest the recently published article by Kundra and his colleagues on the use of inhaled milrinone and inhaled levosimendan in patients with pulmonary hypertension. 1 We wish to make the following comments.…”

“…SEVERE BLEEDING refractory to platelet transfusion can occur in ticagrelor-treated patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). 1,2 Postoperative bleeding risk is mitigated by holding ticagrelor for 3 days before surgery. 3 Ticagrelor undergoes hepatic metabolism via cytochrome (CYP) 3A4, forming active and inactive metabolites.…”