In Reply to “Malignant Mesothelioma and Its Nonasbestos Causes”

Attanoos, Richard; Churg, Andrew; Galateau-Salle, Françoise; Gibbs, A R; Roggli, Victor L.

doi:10.5858/arpa.2019-0060-le

Cited by 3 publications

(4 citation statements)

References 29 publications

(30 reference statements)

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“…Malignant mesothelioma is strongly associated with exposure to asbestos (8-11). Other etiological factors are genetic predisposition (12-14), radiation exposure, and viral infection that alone or together with asbestos exposure can cause malignant mesotheliomas (15,16).Mesotheliomas carry acquired genetic aberrations (17). Cytogenetic analysis of 131 tumors has shown that most mesotheliomas have complex karyotypes (18).…”

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confidence: 99%

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Genetic Pathways in Peritoneal Mesothelioma Tumorigenesis

Panagopoulos

Andersen

Brunetti

et al. 2023

Cancer Genomics Proteomics

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Background/Aim: Mesotheliomas are tumors similar to, and probably derived from, mesothelial cells. They carry acquired chromosomal rearrangements, deletions affecting CDKN2A, pathogenetic polymorphisms in NF2, and fusion genes which often contain the promiscuous EWSR1, FUS, and ALK as partner genes. Here, we report the cytogenomic results on two peritoneal mesotheliomas. Materials and Methods: Both tumors were examined using G-banding with karyotyping and array comparative genomic hybridization (aCGH). One of them was further investigated with RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), Sanger sequencing, and fluorescence in situ hybridization (FISH). Results: In the first mesothelioma, the karyotype was 25~26,X,+5,+7,+20[cp4]/50~52,idemx2[cp7]/46,XX [2]. aCGH detected gains of chromosomes 5, 7, and 20 with retained heterozygosity on these chromosomes. In the second tumor, the karyotype was 46,XX,inv(10)(p11q25) [7]/46,XX [3]. aCGH did not detect any gains or losses and showed heterozygosity for all chromosomes. RNA sequencing, RT-PCR/Sanger sequencing, and FISH showed that the inv(10) fused MAP3K8 from 10p11 with ABLIM1 from 10q25. The MAP3K8::ABLIM1 chimera lacked exon 9 of MAP3K8. Conclusion: Our data, together with information on previously described mesotheliomas, illustrate two pathogenetic mechanisms in peritoneal mesothelioma: One pathway is characterized by hyperhaploidy, but with retained disomies for chromosomes 5, 7, and 20; this may be particularly prevalent in biphasic mesotheliomas. The second pathway is characterized by rearrangements of MAP3K8 from which exon 9 of MAP3K8 is lost. The absence of exon 9 from oncogenetically rearranged MAP3K8 is a common theme in thyroid carcinoma, lung cancer, and spitzoid as well as other melanoma subtypes.Mesotheliomas are rare, mostly malignant tumors similar to, and probably derived from, mesothelial cells, i.e., the cells lining the body's serous cavities (1-3). More than 80% of mesotheliomas are developed in the wall lining of the pleural cavity, 7% in the peritoneum, 1% in the pericardium, and less than 1% in the tunica vaginalis (4, 5). The three histological types, epithelioid, sarcomatoid, and biphasic (the latter subtype has both epithelioid and sarcomatous differentiation), account for 50-60%, 10%, and 30-40% of mesotheliomas, respectively (3), and influence disease prognosis (6, 7). Malignant mesothelioma is strongly associated with exposure to asbestos (8-11). Other etiological factors are genetic predisposition (12-14), radiation exposure, and viral infection that alone or together with asbestos exposure can cause malignant mesotheliomas (15,16).Mesotheliomas carry acquired genetic aberrations (17). Cytogenetic analysis of 131 tumors has shown that most mesotheliomas have complex karyotypes (18). Comparative genomic hybridization, loss of heterozygosity, and fluorescence in situ hybridization (FISH) studies have detected nonrandom gains and losses of chromosomal regions (19-21). Deletions of or from chromosome arms 1p, 3...

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confidence: 99%

mentioning

confidence: 99%

Genetic Pathways in Peritoneal Mesothelioma Tumorigenesis

Panagopoulos

Andersen

Brunetti

et al. 2023

Cancer Genomics Proteomics

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“…Currently, 70-90% of MPM cases in North America and Europe are attributed to asbestos exposure. Although most cases are reported in men, there is a higher proportion of women with MPM in Europe who are attributed to asbestos exposure [35]. In an analysis reported by Teta et al [36], wherein they reviewed National Cancer Institute's Surveillance Epidemiology and End Results registry data from 1973 to 2002, mesothelioma was rare in younger age groups, and stable and similar for both sexes, but the incidence was still higher in men older than 60 years [36].…”

Section: Malignant Mesotheliomamentioning

confidence: 99%

“…In some parts of the world, there have been reports of nonoccupational exposure from naturally occurring asbestos fibre in the soil. Although some small epidemiologic studies attempt to clear and report an increasing number of cases in these regions, a common confounding factor is that a member of the household carries an occupational risk [35]. In one meta-analysis of cases of MPM in nonoccupational exposures, they found a strong correlation between the incidence of MPM and neighbourhood or household exposure.…”

Section: Malignant Mesotheliomamentioning

confidence: 99%

Asbestos-associated pulmonary disease

Caceres

Venkata

2023

Current Opinion in Pulmonary Medicine

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Purpose of reviewExposure to asbestos can cause both benign and malignant, pulmonary and pleural diseases. In the current era of low asbestos exposure, it is critical to be aware of complications from asbestos exposure; as they often arise after decades of exposure, asbestos-related pulmonary complications include asbestosis, pleural plaques, diffuse pleural thickening, benign asbestos-related pleural effusions and malignant pleural mesothelioma.Recent findingsMultiple recent studies are featured in this review, including a study evaluating imaging characteristics of asbestos with other fibrotic lung diseases, a study that quantified pleural plaques on computed tomography imaging and its impact on pulmonary function, a study that examined the risk of lung cancer with pleural plaques among two large cohorts and a review of nonasbestos causes of malignant mesothelioma.SummaryAsbestos-related pulmonary and pleural diseases continue to cause significant morbidity and mortality. This review summarizes the current advances in this field and highlights areas that need additional research.

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Malignant mesothelioma following exposure to cosmetic talc: Association, not causation

Geyer¹

2020

American J Industrial Med

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In Reply to “Malignant Mesothelioma and Its Nonasbestos Causes”

Cited by 3 publications

References 29 publications

Genetic Pathways in Peritoneal Mesothelioma Tumorigenesis

Genetic Pathways in Peritoneal Mesothelioma Tumorigenesis

Asbestos-associated pulmonary disease

Malignant mesothelioma following exposure to cosmetic talc: Association, not causation

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