In reply to Hynes <i>et al</i>.: ‘Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stages <scp>II</scp>/<scp>III</scp> colon cancer in a large population‐based study’

Pelt, Gabi W. van; Huijbers, A.; Tollenaar, Rob A.E.M.; Mesker, Wilma E.

doi:10.1111/his.13396

Cited by 1 publication

(1 citation statement)

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“…Moreover, in different types of cancer, the quantity of CAFs is associated with bad prognosis [42][43][44]. However, the existence of different CAF subpopulations associated with different functions has been demonstrated [45,46].…”

Section: Cancer-associated Fibroblastsmentioning

confidence: 99%

The Tumor Microenvironment in Liver Metastases from Colorectal Carcinoma in the Context of the Histologic Growth Patterns

Garcia-Vicién

Mezheyeuski

Bañuls

et al. 2021

IJMS

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Colorectal carcinoma (CRC) is the third most common cancer. Likewise, it is a disease that has a long survival if it is prematurely detected. However, more than 50% of patients will develop metastases, mainly in the liver (LM-CRC), throughout the evolution of their disease, which accounts for most CRC-related deaths. Treatment it is certainly a controversial issue, since it has not been shown to increase overall survival in the adjuvant setting, although it does improve disease free survival (DFS). Moreover, current chemotherapy combinations are administered based on data extrapolated from primary tumors (PT), not considering that LM-CRC present a very particular tumor microenvironment that can radically condition the effectiveness of treatments designed for a PT. The liver has a particular histology and microenvironment that can determine tumor growth and response to treatments: double blood supply, vascularization through fenestrated sinusoids and the presence of different mesenchymal cell types, among other particularities. Likewise, the liver presents a peculiar immune response against tumor cells, a fact that correlates with the poor response to immunotherapy. All these aspects will be addressed in this review, putting them in the context of the histological growth patterns of LM-CRC, a particular pathologic feature with both prognostic and predictive repercussions.

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