In Pursuit of Genes of Glucose Metabolism

Granner, Daryl K.

doi:10.1074/jbc.x115.681353

Cited by 22 publications

(22 citation statements)

References 83 publications

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“…gluconeogenesis (46,47), might help generate glucose as the carbon source for FA synthesis. The increased total ACC should also support lipogenesis, although the increased phosphor-ACC might inhibit ACC complex activity (48).…”

Section: Discussionmentioning

confidence: 99%

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

Zhao

Barcus

Kim

et al. 2016

The Journal of Nutrition

102

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Section: Discussionmentioning

confidence: 99%

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

Zhao

Barcus

Kim

et al. 2016

The Journal of Nutrition

102

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“…[25][26][27] In addition, glucocorticoids induce peripheral insulin resistance. 27) Although the serum concentration of corticosterone increased after the infusion of olanzapine in the present study, no significant difference was noted among the olanzapine dose groups (Fig.…”

Section: Discussionmentioning

confidence: 99%

Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine

Nagata

Nakajima

Ishiwata

et al. 2016

Biological & Pharmaceutical Bulletin

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Acute administration of olanzapine rapidly elevates blood glucose levels. However, the mechanism underlying the rapid development of hyperglycemia with the administration of olanzapine remains unclear. The aim of the present study was to clarify the mechanism underlying olanzapine-induced acute hyperglycemia. Male Wistar rats received an intravenous infusion of saline (control) or olanzapine 2.5, 5, or 10 mg/kg. Blood samples were obtained periodically after olanzapine infusion to determine serum concentrations of glucose, olanzapine, and several endogenous substances. In a separate experiment, rats received an intravenous injection of propranolol (2 mg/kg) 30 min before infusion of olanzapine (10 mg/kg). The intravenous infusion of olanzapine induced dose-dependent increases in the serum concentrations of glucose, epinephrine, and insulin. Pretreatment with propranolol suppressed olanzapine-induced elevations in the serum concentration of glucose, but did not affect the serum concentration of olanzapine or olanzapine-induced increase in the serum concentration of epinephrine. Although the serum concentration of corticosterone increased after administration of olanzapine, no significant differences were observed among the olanzapine dose groups. Furthermore, administration of olanzapine did not affect the serum concentration of glucagon or histamine. We developed a pharmacokinetic-pharmacodynamic model assuming that the olanzapine-induced secretion of epinephrine leads to elevated serum glucose concentrations. This model appeared to satisfactorily characterize olanzapine-induced hyperglycemia. In conclusion, a single intravenous dose of olanzapine dosedependently increased the serum concentration of glucose in rats, and epinephrine plays a role in olanzapineinduced acute hyperglycemia.

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“…Thyroid hormone action has been long recognized as a significant determinant of glucose homeostasis [79,80]. Glucose homeostasis appears to be the result of the T3 and insulin synergistic regulation of gene transcription involved metabolic pathways of glucose and lipids [81]. T3 regulates a gene expression of glucose metabolism (the enzymes for oxidation of glucose and lipids, glucose storage, glycolysis, cholesterol synthesis, and glucose-lipid metabolism) [82].…”

Section: Role Of the Hypothalamic-pituitary Axis In The Glucose Homeomentioning

confidence: 99%

Glucose Homeostasis

Szablewski¹

2017

Gluconeogenesis

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In Pursuit of Genes of Glucose Metabolism

Cited by 22 publications

References 83 publications

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

Mechanism Underlying Induction of Hyperglycemia in Rats by Single Administration of Olanzapine

Glucose Homeostasis

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