In premature luteinization, progesterone induces secretory transformation of the endometrium without impairment of embryo viability

Chetkowski, Ryszard J.; Kiltz, R.J.; Salyer, William R.

doi:10.1016/s0015-0282(97)81518-x

Cited by 55 publications

(35 citation statements)

References 24 publications

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“…It has also been suggested that raised progesterone concentrations are likely to influence endometrial development, which could in turn lead to a change in the normal synchrony between the embryo and the endometrium when excessively disturbed [24-26]. One strategy to prevent the hypothetical effects of progesterone elevation on uterine receptivity might be to vitrify all embryos and then transfer embryos during a later cycle [27].…”

Section: Discussionmentioning

confidence: 99%

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study

Requena

Cruz

Bosch

et al. 2014

Reprod Biol Endocrinol

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BackgroundThe potentially detrimental role of progesterone during the follicular phase has been a matter of controversy for several years; however, few studies have analyzed the effects of combined raised estradiol and progesterone levels on pregnancy outcomes. The aim of the present study was to determine the influence of high progesterone levels on clinical outcomes in the context of high ovarian response.MethodsWe performed a retrospective cohort study that included 2850 women classified as high responders. The women were subdivided into six groups depending on their progesterone concentration on the day of human chorionic gonadotropin (hCG) administration: <0.5 ng/ml (1.81 ng/ml (>p90). Ovarian response was classified as high when > =20 oocytes were retrieved or when estradiol was > =3000 pg/ml. Clinical outcomes of each subgroup were analyzed. We also examined data from frozen-thawed embryo transfers. Results were analyzed with Student’s t- test to compare continuous variables and chi-squared test to compare proportions. A p-value of < =0.05 was considered statistically significant.ResultsThe progesterone concentration increased with ovarian response, and elevated progesterone did not show a significant clinical impact on implantation rate and pregnancy rates. These data provide evidence that progesterone levels higher than 1.8 ng/ml do not have detrimental effect on oocyte quality or endometrial receptivity.ConclusionsThese data allow us to conclude that high progesterone levels correlate significantly with high estradiol levels and that in high responder women; progesterone levels do not show a significant clinical impact on results.

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Section: Discussionmentioning

confidence: 99%

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study

Requena

Cruz

Bosch

et al. 2014

Reprod Biol Endocrinol

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show abstract

“…It was reported to cause adversities on oocyte maturation, fertilization, or early cleavage (43,44,46,50). Many investigators have reported that it does not affect embryo quality (51)(52)(53) and the detrimental affect may be on endometrium (54).…”

Section: Bukulmez Serum Cetrorelix Levels In Art Fertil Steril 2008mentioning

confidence: 99%

Serum cetrorelix concentrations do not affect clinical pregnancy outcome in assisted reproduction

Bükülmez

Carr

Doody

et al. 2008

Fertility and Sterility

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“…Premature luteinization (PL) has been variously defined based on serum P levels, with thresholds of 0.9-1.5 ng/mL being used (16,(23)(24)(25)(26)(27). This center has previously reported detrimental effects on implantation when serum P was at least 1.0 ng/mL (8).…”

mentioning

confidence: 99%

Embryo cryopreservation rescues cycles with premature luteinization

Shapiro

Daneshmand

Garner

et al. 2010

Fertility and Sterility

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In premature luteinization, progesterone induces secretory transformation of the endometrium without impairment of embryo viability

Cited by 55 publications

References 24 publications

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study

Serum cetrorelix concentrations do not affect clinical pregnancy outcome in assisted reproduction

Embryo cryopreservation rescues cycles with premature luteinization

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