In-plane oriented highly ordered lamellar structure formation of poly(N-dodecylacrylamide) induced by humid annealing

Hashimoto, Yuki; Sato, Takuma; Goto, Ryosuke; Nagao, Yuki; Mitsuishi, Masaya; Nagano, Shusaku; Matsui, Jun

doi:10.1039/c6ra27994e

Cited by 37 publications

(74 citation statements)

References 29 publications

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“…In addition, the XRD pattern images, as shown in Figure 2f, also indicate that, after incubation at the neutral condition for 24 h, the spot-like crystalline diffractions could be discovered within the TPM mixed micelles. The diffraction pattern of the TPM mixed micelles is represented in the ordered crystalline structure, aligning with the out-of-plane direction [24]. The crystalline spots disappeared in the XRD pattern image of the acid-treated TPM micelles in Figure 2g, demonstrating that the crystalline nanodomains in TPM mixed micelles would be disordered at pH 4.0, in harmony with the results of the XRD pattern in Figure 2c.…”

Section: Ph Responsiveness Of the Ph-responsive Secondary Structure Csupporting

confidence: 72%

“…Therefore, it is not surprising to discover the crystalline formations by XRD analysis within a mixed micellar system, in Figure 2c,f [35]. In our case, the crystalline structure would align in a lamellar manner and grow out-of-plane [24]. WARD results show that 2 θ = 2 and 6, showing that the distances between the α-helices of the PBLG and the pitch length of α-helices were 4.415 and 1.472 nm, respectively.…”

Section: Discussionmentioning

confidence: 64%

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A Novel pH-Tunable Secondary Conformation Containing Mixed Micellar System in Anticancer Treatment

Shih

Jiang

Lin

et al. 2020

Cancers

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In this study, for the first time, we precisely assembled the poly-γ-benzyl-l-glutamate and an amphiphilic copolymer d-α-tocopherol polyethylene glycol succinate into a mixed micellar system for the embedment of the anticancer drug doxorubicin. Importantly, the intracellular drug-releasing behaviors could be controlled by changing the secondary structures of poly-γ-benzyl-l-glutamate via the precise regulation of the buffer’s pH value. Under neutral conditions, the micellar architectures were stabilized by both α-helix secondary structures and the microcrystalline structures. Under acidic conditions (pH 4.0), the interior structures transformed into a coil state with a disordered alignment, inducing the release of the loaded drug. A remarkable cytotoxicity of the Dox-loaded mixed micelles was exhibited toward human lung cancer cells in vitro. The internalizing capability into the cancer cells, as well as the intracellular drug-releasing behaviors, were also identified and observed. The secondary structures containing Dox-loaded mixed micelles had an outstanding antitumor efficacy in human lung cancer A549 cells-bearing nude mice, while little toxicities occurred or interfered with the hepatic or renal functions after the treatments. Thus, these pH-tunable α-helix-containing mixed micelles are innovative and promising for controlled intracellular anticancer drug delivery.

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Section: Ph Responsiveness Of the Ph-responsive Secondary Structure Csupporting

confidence: 72%

Section: Discussionmentioning

confidence: 64%

A Novel pH-Tunable Secondary Conformation Containing Mixed Micellar System in Anticancer Treatment

Shih

Jiang

Lin

et al. 2020

Cancers

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“…The XRD pattern in Fig. 2a reveals 3 diffractions with a spacing ratio of 1:2:3, corresponding to the (100), (200), and (300) Miller Indices of a 2D lamellar mesostructure 65 , 66 . The distance between the bilayers is estimated with the Bragg equation to be 3.43 nm, which is 0.2 nm smaller than twice the extending length of the oleate molecule (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Generating circularly polarized luminescence from clusterization‐triggered emission using solid phase molecular self-assembly

Liao

Zang

et al. 2021

Nat Commun

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Purely-organic clusterization‐triggered emission (CTE) has displayed promising abilities in bioimaging, chemical sensing, and multicolor luminescence. However, it remains absent in the field of circularly polarized luminescence (CPL) due to the difficulties in well-aligning the nonconventional luminogens. We report a case of CPL generated with CTE using the solid phase molecular self-assembly (SPMSA) of poly-L-lysine (PLL) and oleate ion (OL), that is, the macroscopic CPL supramolecular film self-assembled by the electrostatic complex of PLL/OL under mechanical pressure. Well-defined interface charge distribution, given by lamellar mesophases of OL ions, forces the PLL chains to fold regularly as a requirement of optimal electrostatic interactions. Further facilitated by hydrogen bonding, the through-space conjugation (TSC) of orderly aligned electron-rich O and N atoms leads to CTE-based CPL, which is capable of transferring energy to an acceptor via a Förster resonance energy transfer (FRET) process, making it possible to develop environmentally friendly and economic CPL from sustainable and renewable materials.

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“…The XRD pattern in Fig. 2a reveals 3 diffractions with a spacing ratio of 1: 2: 3, corresponding to the (100), ( 200) and (300) Miller Indices of a 2D lamellar mesostructure 56,57 . The distance between the bilayers is estimated with Bragg equation to be 3.43 nm.…”

Section: Resultsmentioning

confidence: 99%

Generating Circularly Polarized Light from Clustering‐Triggered Emission Using Solid Phase Molecular Self-Assembly

Liao¹,

Zang²,

Wu³

et al. 2021

Preprint

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Clustering-triggered emission (CTE) has displayed promising abilities in bioimaging, chemical sensing, and multicolor luminescence. However, it remains absent in the field of circularly polarized emission (CPL) due to the difficulties in well-aligning the nonconventional luminogens. We report the first case of CPL generated with CTE using the solid phase molecular self-assembly(SPMSA) of poly-L-lysine(PLL) and sodium oleate (OL). Under mechanical pressure, the electrostatic complex of PLL/OL form supramolecular film in which the OL ions self-assemble into lamellar mesophases bridged by the PLL chains. Since the OL mesophases are very alike giant 2D rigid supramolecular polymers with well-defined surface charge distribution, the PLL chains are forced to fold regularly as a requirement of optimal electrostatic interaction. Further facilitated by hydrogen bonding, the O and N atoms that form through space conjugation aligned orderly on the 2D surface, leading to CTE-based CPL. The CTE-based CPL is in analogy with conventional emission, which is capable to transfer its energy to a donor via a FRET process, making it possible to develop environmental friendly and economic CPL from sustained and renewable materials.

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In-plane oriented highly ordered lamellar structure formation of poly(N-dodecylacrylamide) induced by humid annealing

Abstract: Highly oriented and ordered lamellar polymer film was prepared by simply annealing the poly(N-dodecylacrylamide) film under humid conditions.

Cited by 37 publications

References 29 publications

A Novel pH-Tunable Secondary Conformation Containing Mixed Micellar System in Anticancer Treatment

A Novel pH-Tunable Secondary Conformation Containing Mixed Micellar System in Anticancer Treatment

Generating circularly polarized luminescence from clusterization‐triggered emission using solid phase molecular self-assembly

Generating Circularly Polarized Light from Clustering‐Triggered Emission Using Solid Phase Molecular Self-Assembly

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