In ovo feeding of IGF‐1 to ducks influences neonatal skeletal muscle hypertrophy and muscle mass growth upon satellite cell activation

Liu, Hehe; Wang, Jiwen; Zhang, Rongping; Chen, Xi; Yu, Haiyue; Jin, Huixia; Li, Liang; Han, Chunchun; Xu, Feng; Kang, Bo; He, Hua; Xu, Hengyong

doi:10.1002/jcp.22862

Cited by 29 publications

(26 citation statements)

References 64 publications

(78 reference statements)

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“…The development of satellite cell specific miR-378 transgenic mice may help clarify the physiological function of miR-378 in muscle cell differentiation in vivo. In addition to its involvement in myogenic differentiation, IGF1R signaling plays important roles in muscle growth and hypertrophy [38]. The IGF1R/Akt pathway is one of the main signaling pathways controlling protein turnover in skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice

Zeng

Han

et al. 2016

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Skeletal muscle mass and homeostasis during postnatal muscle development and regeneration largely depend on adult muscle stem cells (satellite cells). We recently showed that global overexpression of miR-378 significantly reduced skeletal muscle mass in mice. In the current study, we used miR-378 transgenic (Tg) mice to assess the in vivo functional effects of miR-378 on skeletal muscle growth and regeneration. Cross-sectional analysis of skeletal muscle tissues showed that the number and size of myofibers were significantly lower in miR-378 Tg mice than in wild-type mice. Attenuated cardiotoxin-induced muscle regeneration in miR-378 Tg mice was found to be associated with delayed satellite cell activation and differentiation. Mechanistically, miR-378 was found to directly target Igf1r in muscle cells both in vitro and in vivo. These miR-378 Tg mice may provide a model for investigating the physiological and pathological roles of skeletal muscle in muscle-associated diseases in humans, particularly in sarcopenia.

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Section: Discussionmentioning

confidence: 99%

miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice

Zeng

Han

et al. 2016

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“…Intriguingly, endothelial and other cells may promote the growth of MuSC through secretion of soluble factors, such as IGF-1, HGF, basic fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor (Yablonka-Reuveni and Rivera, 1997; Yablonka-Reuveni et al, 1999; Kästner et al, 2000; Zhao et al, 2003; Christov et al, 2007; Deasy et al, 2009). Consequently, in ovo administration of IGF-1 leads to satellite cell activation, neonatal skeletal muscle hypertrophy, and increased muscle mass (Liu et al, 2011). Furthermore, angiopoietin 1/ Tie-2 (tyrosine kinase, endothelial) signaling, an active regulator for vascular homeostasis, has been shown to promote MuSC self-renewal both by autocrine and paracrine effects (Shim et al, 2007; Abou-Khalil et al, 2009).…”

Section: Satellite Cell Nichementioning

confidence: 99%

MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM: Stem cell niche and postnatal muscle growth1,2

Kuang

2012

Journal of Animal Science

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Stem cell niche plays a critical role in regulating the behavior and function of adult stem cells that underlie tissue growth, maintenance, and regeneration. In the skeletal muscle, stem cells, called satellite cells, contribute to postnatal muscle growth and hypertrophy, and thus, meat production in agricultural animals. Satellite cells are located adjacent to mature muscle fibers underneath a sheath of basal lamina. Microenvironmental signals from extracellular matrix mediated by the basal lamina and from the host myofiber both impinge on satellite cells to regulate their activity. Furthermore, several types of muscle interstitial cells, including intramuscular preadipocytes and connective tissue fibroblasts, have recently been shown to interact with satellite cells and actively regulate the growth and regeneration of postnatal skeletal muscles. From this regard, interstitial adipogenic cells are not only important for marbling and meat quality, but also represent an additional cellular component of the satellite cell niche. At the molecular level, these interstitial cells may interact with satellite cells through cell surface ligands, such as delta-like 1 homolog (Dlk1) protein whose overexpression is thought to be responsible for muscle hypertrophy in callipyge sheep. In fact, extracellular Dlk1 protein has been shown to promote the myogenic differentiation of satellite cells. Understanding the cellular and molecular mechanisms within the stem cell niche that regulate satellite cell differentiation and maintain muscle homeostasis may lead to promising approaches to optimizing muscle growth and composition, thus improving meat production and quality.

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“…This amino acid regulates some key signalling pathways, such as the activation of the mammalian target of rapamycin (mTOR) (Chang et al, ; Zhang et al, ) to stimulate protein synthesis and also to inhibit intracellular proteolysis (Li, Yin, Tan, Kong, & Wu, ). Therefore, dietary leucine has been found to promote the gene expression of the mTOR signalling pathway by increasing β‐hydroxy‐β‐methylbutyrate (HMB) formation (Kornasio et al, ; Li et al, ), insulin‐like growth factor 1 (IGF‐1) production (Liu et al, ) and intestinal amino acid transportation and consequently development in broilers (Chang et al, ; Zhang et al, ). Furthermore, BCAAs, and especially isoleucine, have a key role in the upregulation of intestinal and muscular glucose transporters and in enhancing glucose consumption and utilization (Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

In ovo injection of branched‐chain amino acids: Embryonic development, hatchability and hatching quality of turkey poults

Bozbay

Ocak

2019

Animal Physiology Nutrition

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In this study, the influence of a branched‐chain amino acid blend (BCAA composed of 3 l‐leucine:1 l‐valine:2 l‐isoleucine) injected into the amniotic fluid was evaluated for embryonic growth, yolk‐sac (YS) utilization and development of gastrointestinal tract (GIT) and skeletal muscles of turkey embryos from day 24 of incubation (24E) to hatching, together with hatchability, poult quality and liver L* (lightness), a* (redness) and b* (yellowness) values at hatch. At day 22 of incubation, embryonated eggs (n = 240) were assigned to three treatments, that is, eggs were not injected (control, NC) or injected with 1.5 ml sterile solution with 0.9% salt (SA) or 0.2% BCAA blend (BCAAb). These solutions were injected manually into the amniotic fluid of the embryonated eggs. To determine weights and lengths (where appropriate) of the studied organs and tissues, four embryonated eggs and poults per treatment were selected at 24E and at hatch. While the BCAAb decreased the YS and embryo weight, hatchability and the liver L* value, it increased the weight and quality of poults and the weights of breast and thigh muscles at hatch. In conclusion, the in ovo feeding of the BCAA blend negatively affected hatchability but positively affected hatching weight and poult quality by improving development of skeletal muscles and by regulating energy metabolism.

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In ovo feeding of IGF‐1 to ducks influences neonatal skeletal muscle hypertrophy and muscle mass growth upon satellite cell activation

Cited by 29 publications

References 64 publications

miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice

miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice

MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM: Stem cell niche and postnatal muscle growth1,2

In ovo injection of branched‐chain amino acids: Embryonic development, hatchability and hatching quality of turkey poults

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