In neutralized medium five new Ca(II), Zn(II), Fe(III), Au(III) and Pd(II) complexity of ceftriaxone antibiotic drug: Synthesis, spectroscopic, morphological and anticancer studies

Refat, Moamen S.; Altalhi, T.; Fetooh, Hammad; Alsuhaibani, Amnah Mohammed; Hassan, Reham F.

doi:10.1016/j.molliq.2020.114816

Cited by 11 publications

(14 citation statements)

References 18 publications

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“…At 90% RH, the material was found to have a mass gain of ~20.45%, which corresponded to ~6.7 water molecules. This result is in agreement with the literature, where, accordingly, the maximum hydration number of this material is seven [22]. From the TG results (Figure 4), the as-synthesized material was found to have (a hydration number of 4.3, which is in agreement with the DVS results.…”

Section: Dehydration-hydration Cyclessupporting

confidence: 91%

“…No repository files (CIF-Crystallographic Information File) were available for CaHS in the International Center for Diffraction Data database. Nevertheless, the patterns match with other results in the literature [22,24]. For completeness, the peaks list and d-spacing of the two materials are reported as Supplementary Information (Tables S1 and S2).…”

Section: Cahs Chemical Analysis Structural and Morphological Characte...supporting

confidence: 86%

“…It should be mentioned that disodium ceftriaxone, despite containing 3.5 H 2 O molecules within its crystal structure, cannot be taken under consideration as a TCM due to its high solubility [21]. It is reasonable to assume that in CaHS the hard acid Ca 2+ can easily interact with the hard base H 2 O and coordinate an expected range of 6-8 water molecules [22,23], according to the most stable coordination number of the calcium aquaione complex. We here carried out a study on the thermochemical behavior of CaHS for TES applications.…”

Section: Introductionmentioning

confidence: 99%

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Organic Salt Hydrate as a Novel Paradigm for Thermal Energy Storage

et al. 2022

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The use of inorganic salt hydrates for thermochemical energy storage (TCS) applications is widely investigated. One of the drawbacks that researchers face when studying this class of materials is their tendency to undergo deliquescence phenomena. We here proposed and investigated, for the first time, the possibility of using organic salt hydrates as a paradigm for novel TCS materials with low water solubility, that is, more resistance to deliquescence, a tendency to coordinate a high number of water molecules and stability under operating conditions. The organic model compound chosen in this study was calcium; 7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, known as calcium ceftriaxone, hereafter named CaHS (calcium hydrated salt), a water-insoluble organic salt, which can combine up to seven water molecules. The CaHS was prepared by precipitation from the water-soluble disodium triaxone. The thermal behavior of CaHS, in terms of stability and dehydration–hydration cyclability, was assessed. The material can operate in the temperature range of 30–150 °C, suitable for TCS. No deliquescence phenomena occurred upon exposure to a relative humidity (RH) between 10 and 100%. Its heat storage capacity, so far unknown, was measured to be ~595.2 kJ/kg (or ~278.6 kWh/m3). The observed heat storage capacity, thermal stability, and good reversibility after dehydration–hydration cycles highlight the potential of this class of materials, thus opening new research paths for the development and investigation of innovative organic salt hydrates.

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Section: Dehydration-hydration Cyclessupporting

confidence: 91%

Section: Cahs Chemical Analysis Structural and Morphological Characte...supporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Organic Salt Hydrate as a Novel Paradigm for Thermal Energy Storage

et al. 2022

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“…Moamen S. Refat et al obtained calcium complex with ceftriaxone. However, this complex has a different structure and luminescence and antibacterial properties were not study [11].…”

Section: Introductionmentioning

confidence: 99%

Complex of Ca(II) with Ceftriaxone: Synthesis, Structure, Spectral and Antibacterial Properties

Novikova¹,

Tsyplenkova²,

Кузубов³

et al. 2021

J. Sib. Fed. Chem.

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The calcium complex of ceftriaxone was synthesized and characterized by elemental, atomic-emission analysis, TGA, IR spectroscopy and density functional theory calculations. The luminescence and antibacterial properties of the ceftriaxone disodium and calcium complex were investigated. Ca(II) complex was obtained in a crystalline form, cell parameters of the compound were determined. Ceftriaxone was coordinated to the calcium ion by the oxygen of the triazine cycle in the 6th position, the nitrogen of the amine group of the thiazole ring, and the oxygens of the lactam carbonyl and carboxylate groups. The complex of Ca(II) with ceftriaxone was screened for antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, and the results were compared with the activity of ceftriaxone disodium salt

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“…[21] The same effect was observed for ceftriaxone, cefradine, cefixime, and cefuroxime complexes with calcium at the ratio metal/antibiotic equal to 1 : 1 or 1 : 2. [21][22][23] Also, the enhancement of activity against bacteria Staphylococcus aureus and Escherichia coli compared to pure antibiotics was demonstrated in the case of [Ca(Antibiotic)NO 3 ] complexes, where Antibiotic = cefradine, cefixime, and cefuroxime. [23] On the other side, it was shown that simultaneous injection of calcium and ceftriaxone preparations into patients' bodies results in sediments in blood plasma, lungs, and kidneys and, as a consequence, to the death of newborns.…”

Section: Introductionmentioning

confidence: 99%

Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination

et al. 2021

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Mg(II) and Ca(II) complexes with cefazolin were synthesized and investigated using elemental and atomic-emission analysis, TGA, X-ray diffraction, FT-IR spectroscopy, 1 H and 13 CNMR, DFT calculations, and QTAIM analysis. The thermal behavior of these complexes was also studied. In the magnesium complex, two cefazolin ions are coordinated to the metal ion through the oxygen atoms of the lactam and carboxylate groups as a bidentate ligand. However, cefazolin chelated to the calcium ion through both oxygen atoms of the carboxylate groups and the lactam groups' oxygen atoms as tridentate ligand. Sodium cefazolin and metal complexes were also screened for antibacterial activity against Staphylococcus aureus and Escherichia coli. The calcium complex exhibited higher antibacterial effects than the magnesium complex (5.2-7.7 % higher against S. aureus-and 15.4-27.3 % against E. coli), which is related to weaker binding of Ca, compared to Mg, with the oxygen atom of lactam group and, as a result, more free releasing of the lactam group in the solving process.

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In neutralized medium five new Ca(II), Zn(II), Fe(III), Au(III) and Pd(II) complexity of ceftriaxone antibiotic drug: Synthesis, spectroscopic, morphological and anticancer studies

Cited by 11 publications

References 18 publications

Organic Salt Hydrate as a Novel Paradigm for Thermal Energy Storage

Organic Salt Hydrate as a Novel Paradigm for Thermal Energy Storage

Complex of Ca(II) with Ceftriaxone: Synthesis, Structure, Spectral and Antibacterial Properties

Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination

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In neutralized medium five new Ca(II), Zn(II), Fe(III), Au(III) and Pd(II) complexity of ceftriaxone antibiotic drug: Synthesis, spectroscopic, morphological and anticancer studies

Cited by 11 publications

References 18 publications

Organic Salt Hydrate as a Novel Paradigm for Thermal Energy Storage

Organic Salt Hydrate as a Novel Paradigm for Thermal Energy Storage

Complex of Ca(II) with Ceftriaxone: Synthesis, Structure, Spectral and Antibacterial Properties

Complex Formation of Cefazolin with Ca2+ and Mg2+: Synthesis, DFT, Spectral and Antibacterial Determination

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Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination