In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias

Hunter, James; Saratzis, Athanasios; Sutton, Alex J.; Boucher, Rebecca H.; Sayers, Robert D.; Bown, Matthew J.

doi:10.1016/j.jclinepi.2014.03.003

Cited by 547 publications

(410 citation statements)

References 30 publications

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“…We used random-effects meta-analyses of proportions to combine data on the prevalence of the placental pathological lesions in pregnancies complicated by PE 17 . We planned an a-priori sensitivity analysis according to the type of PE, whether the pathologist was blinded or not to the clinical information and whether the cases were gestational age-matched to controls or not.…”

Section: Risk Of Bias Summary Measures and Synthesis Of Resultsmentioning

confidence: 99%

Placental histopathology associated with pre‐eclampsia: systematic review and meta‐analysis

Falco

Sivanathan

Laoreti

et al. 2017

Ultrasound in Obstet & Gyne

110

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Section: Risk Of Bias Summary Measures and Synthesis Of Resultsmentioning

confidence: 99%

Placental histopathology associated with pre‐eclampsia: systematic review and meta‐analysis

Falco

Sivanathan

Laoreti

et al. 2017

Ultrasound in Obstet & Gyne

110

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“…We used random-effect meta-analyses of proportions to combine data (Hunter et al, 2014;Manzoli et al, 2011). The survival was analyzed according to the intervention received, including conservative management, amnioreduction, and endoscopic laser photocoagulation.…”

Section: Risk Of Bias Summary Measures and Synthesis Of The Resultsmentioning

confidence: 99%

Evolution of Stage 1 Twin-to-Twin Transfusion Syndrome (TTTS): Systematic Review and Meta-Analysis

et al. 2016

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Objectives: The natural history of stage 1 Twin-to-twin transfusion syndrome (TTTS) remains unclear and its optimal management is yet to be established. The main aims of this meta-analysis were to quantify the incidence of progression in stage 1 TTTS and to ascertain survival in these pregnancies. Methods: MEDLINE, EMBASE, and The Cochrane Library were searched. Reference lists within each article were hand-searched for additional reports. The outcomes included incidence of progression and survival in stage 1 TTTS. Randomized controlled trials, cohort and case-control studies were included. Case reports, studies including three or fewer cases of stage 1 TTTS, and editorials were excluded. Proportion metaanalysis was used for analysis (Registration number: CRD42016036190). Results: The search yielded 3,085 citations; 18 studies were included in the review (172 pregnancies to assess progression and 433 pregnancies to assess the survival

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“…45 Funnel plots (Supplemental Figs 10, 11, 12, 13, and 14) displaying the outcome rate from individual studies versus their precision (1 per SE) were carried out with an exploratory aim. Tests for funnel plot asymmetry were not used when the 5 by guest on May 12, 2018 http://pediatrics.aappublications.org/ Downloaded from total number of publications included for each outcome was <10.…”

Section: Study Selection Data Collection and Data Itemsmentioning

confidence: 99%

“…In this case, the power of the tests is too low to distinguish chance from real asymmetry. 45,46 Between-study heterogeneity was explored using the I 2 statistic, which represents the percentage of between-study variation that is due to heterogeneity rather than chance. A value of 0% indicates no observed heterogeneity, whereas I 2 values ≥50% indicate a substantial level of heterogeneity.…”

Section: Study Selection Data Collection and Data Itemsmentioning

confidence: 99%

Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis

et al. 2016

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CONTEXT: Antenatal counseling in cases of agenesis of the corpus callosum (ACC) is challenging. OBJECTIVES:To ascertain the outcome in fetuses with isolated complete ACC and partial ACC.DATA SOURCES: Medline, Embase, CINAHL, and Cochrane databases. STUDY SELECTION:Studies reporting a prenatal diagnosis of ACC. The outcomes observed were: chromosomal abnormalities at standard karyotype and chromosomal microarray (CMA) analysis, additional anomalies detected only at prenatal MRI and at postnatal imaging or clinical evaluation, concordance between prenatal and postnatal diagnosis and neurodevelopmental outcome.DATA EXTRACTION: Meta-analyses of proportions were used to combine data. RESULTS:Twenty-seven studies were included. In cACC, chromosomal anomalies occurred in 4.81% (95% confidence interval [CI], 2.2-8.4) of the cases. Gross and fine motor control were abnormal in 4.40% (95% CI, 0.6-11.3) and 10.98% (95% CI, 4.1-20.6) of the cases, respectively, whereas 6.80% (95% CI, 1.7-14.9) presented with epilepsy. Abnormal cognitive status occurred in 15.16% (95% CI, 6.9-25.9) of cases. In partial ACC, the rate of chromosomal anomalies was 7.45% (95% CI, 2.0-15.9). Fine motor control was affected in 11.74% (95% CI, 0.9-32.1) of the cases, and 16.11% (95% CI, 2.5-38.2) presented with epilepsy. Cognitive status was affected in 17.25% (95% CI, 3.0-39.7) of cases.LIMITATIONS: Different neurodevelopmental tools and time of follow-up of the included studies.CONCLUSIONS: Children wih a prenatal diagnosis of isolated ACC show several degrees of impairment in motor control, coordination, language, and cognitive status. However, in view of the large heterogeneity in outcomes measures, time at follow-up, and neurodevelopmental tools used, large prospective studies are needed to ascertain the actual occurrence of neuropsychological morbidity of children with isolated ACC.

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In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias

Cited by 547 publications

References 30 publications

Placental histopathology associated with pre‐eclampsia: systematic review and meta‐analysis

Placental histopathology associated with pre‐eclampsia: systematic review and meta‐analysis

Evolution of Stage 1 Twin-to-Twin Transfusion Syndrome (TTTS): Systematic Review and Meta-Analysis

Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis

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