In memory of Michael R. Detty, PhD

Abstract

On 1 July 2020, the chemistry community sadly lost Michael R. Detty, a professor and former chair in the Department of Chemistry of the University at Buffalo. Testimonials from David Watson and colleagues from University at Buffalo, and Stefan Harmsen from University of Pennsylvania, highlight Professor Detty's accomplishments as researcher, inventor, teacher, mentor, collaborator, and colleague, and his lasting impact on dye chemistry.

Nanomaterial‐Based Strategies for Preventing Tumor Metastasis by Interrupting the Metastatic Biological Processes

“…Compared with traditional materials, nanomaterials have special physicochemical properties and good prospects for medical applications. For example, fluorescence and photothermal effects can be used in the diagnosis and treatment of tumors; [30] the large specific surface area makes it easy for surface modification of various small molecules to enhance biocompatibility and active tumor targeting, and the extremely small size is conducive for nanomedicines to cross the blood-brain barrier and other areas that are not easily accessible to conventional drugs. [30][31] In addition, the unique EPR effect promotes the passive accumulation of nanoparticles (NPs) around the tumor, [32] thereby enhancing the therapeutic effect by increasing the concentration of nanomedicines in the tumor areas and decreasing their effect on normal tissues.…”

“…For example, fluorescence and photothermal effects can be used in the diagnosis and treatment of tumors; [30] the large specific surface area makes it easy for surface modification of various small molecules to enhance biocompatibility and active tumor targeting, and the extremely small size is conducive for nanomedicines to cross the blood-brain barrier and other areas that are not easily accessible to conventional drugs. [30][31] In addition, the unique EPR effect promotes the passive accumulation of nanoparticles (NPs) around the tumor, [32] thereby enhancing the therapeutic effect by increasing the concentration of nanomedicines in the tumor areas and decreasing their effect on normal tissues. Consequently, the use of nanomaterials to target these key components of tumor metastasis, thereby blocking metastatic processes and preventing tumor metastasis, seems to be a promising strategy.…”