Abstract:Lymphoblastic leukemia-derived sequence 1 (Lyl1) encodes a hematopoietic-and endothelial-specific transcriptional factor. Lyl1-deficient mice are viable, but they display mild hematopoietic and vascular defects. Here, we report that young Lyl1 -/mice exhibit transient obesity associated with general expansion of adipose tissues and unrelated to food intake.The increased fat tissue development in Lyl1 -/mice resulted from an earlier adipocyte differentiation of adipose stem cells (ASCs) through non-cell autonom… Show more
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