Citrullus colocynthis has been used to treat obesity and hyperlipidemia.
Nanoparticles, due to their nano size, phytochemical adsorption, improved
systemic absorption and high bioavailability, can potentially improve the
bioactivity of C. colocynthis. The present research focused on studying the
effects of green synthesized calcium oxide nanoparticles (CaONPs) from C.
colocynthis fruit extracts (CCFE) on the body weight, the atherogenic index
of plasma (AIP), and the histopathology of male albino rats.
Ethyl??-d-glucopyranoside was the major constituent of CCFE, along with
phenols and fatty acids. The total phenolic and flavonoid contents of CCFE
were 203.52 and 173.56 mg/g, respectively. Male albino rats (n=36) were
divided into six groups (six rats per each group). Rats in different groups
received a normal diet, a high?fat diet (HFD), HFD with lovastatin (10
mg/kg), HFD with CCFE (20 mg/kg), HFD with CaONPs (2 mg/kg), and HFD with a
synergistic solution of CCFE (10 mg/kg) and CaONPs (1 mg/kg), respectively.
When CaONPs were administered in combination with CCFE, significant
weight-lowering activity (36.36%), improved cardiovascular health as per AIP
(0.12?0.01b), and fewer disturbances in liver function parameters were
observed. Histological analysis at the end of the experiment showed that
CaONPs were not toxic to the gastric mucosa and were slightly toxic to
hepatocytes. It can be concluded that CaONPs synthesized from CCFE can be a
potent weight-lowering and antilipidemic agent with fewer side effects.