In-hospital mortality among patients with takotsubo cardiomyopathy: A study of the National Inpatient Sample 2008 to 2009

Brinjikji, Waleed; El-Sayed, Abdulrahman M.; Salka, Samer

doi:10.1016/j.ahj.2012.04.010

Cited by 273 publications

(231 citation statements)

References 23 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…3). In-hospital cardiac mortality from TCM ranges from 0 to 2% (3,13) while all-cause mortality ranges from 0 to 9% (2,6,13,14). A diagnosis of TCM as a cause of cardiac arrest and shock can only be made if the patient survives the initial insult (15).…”

Section: Discussionmentioning

confidence: 99%

“…Prevalence of complications including cardiogenic shock is reported to be as high as 20% patients (1)(2)(3)(4) though the pathogenesis remains elusive and under-estimation can be disastrous. Pre-existent literature has attempted to identify various risk factors that may pre-dispose to cardiogenic shock in such patients, including the role of gender, age, BMI, coronary disease risk factors (diabetes, hypertension or smoking), electrolyte imbalance, extent of ischemic damage and pathological changes in myocardium identified on echocardiography (5)(6)(7)(8). An understanding of the risk factors inherent to the patient as well as the disease related manifestations linked to presentation with shock can help early risk-stratification, assessment of severity, anticipation of the future course and guide appropriate therapy.…”

Section: Background/objectivesmentioning

confidence: 99%

See 1 more Smart Citation

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Vaidya

Madhira

2017

ICFJ

View full text Add to dashboard Cite

Introduction: Presentation of Takotsubo cardiomyopathy(TCM) widely varies amongst the patients, ranging from asymptomatic patients to cardiogenic shock or even cardiac arrest. The underlying risk factors inherent to the patient that predispose to a catastrophic presentation have not been delineated well in the past.Objective: To distinguish risk factors and presenting characteristics of patients diagnosed with cardiogenic shock from TCM.Methods: Total 51 angiography-confirmed TCM patients admitted in Upstate Hospital from 2010 – 2014 were compared retrospectively, 13 presenting with cardiogenic shock.Results: While TCM was predominantly common in elderly females, four of the total six male TCM patients presented with shock (Odds ratio= 8.0, p=0.027). TSH was higher in cardiogenic shock group. Patients with shock had significantly higher incidence of ST elevations on EKG and higher peak troponins. Moreover, ST elevations were predominantly in the inferior, anteroseptal and lateral leads in the shock group as compared to only the septal leads in the control group. Echocardiography revealed lower LV ejection fraction, LV outflow tract obstruction and concomitant significant mitral regurgitation in shock patients. No correlation was found with age, BMI, coronary disease risk factors (diabetes, hypertension, smoking), coincident infection, electrolyte imbalance, QTc interval length.Conclusion: Risk factors and pathophysiology for cardiogenic shock in TCM were identified. TCM in males is rare, but male gender is a risk factor for shock.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Background/objectivesmentioning

confidence: 99%

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Vaidya

Madhira

2017

ICFJ

View full text Add to dashboard Cite

show abstract

“…Większość publikacji ocenia śmiertelność krótkoterminową na 2-3% [13,15,16], jednak w niektórych badaniach sięga ona 8,9% [17]. W dużym rejestrze obejmującym 24 701 pacjentów śmiertelność wewnątrzszpitalna wynosiła 4,2% [18].…”

Section: Rokowanie Krótkoterminoweunclassified

“…Również średnia długość hospitalizacji była większa w tej grupie chorych [13]. Główną przyczyną zgonów w szpitalu u pacjentów z TTC były choroby współistniejące [18].…”

Section: Rokowanie Krótkoterminoweunclassified

“…U osób, u których czynnikiem wywołującym TTC był czynnik psychiczny oraz u których nie udało się znaleźć czynnika sprawczego, częściej wystę-powała konieczność zastosowania leków inotropowych i diuretycznych, a także pacjenci ci wymagali dłuższego pobytu na oddziale intensywnej terapii oraz dłużej pozostawiali w szpitalu [21]. Również płeć męska wiązała się z większą śmiertelnością wewnątrzszpitalną [18].…”

Section: Rokowanie Krótkoterminoweunclassified

See 1 more Smart Citation

Parametry echokardiograficzne wpływające na rokowanie pacjentów z kardiomiopatią takotsubo

Budnik

2017

Folia Cardiologica

View full text Add to dashboard Cite

StreszczenieKardiomiopatia takotsubo to odwracalna dysfunkcja skurczowa lewej komory, której objawy przypominają ostry zespół wieńcowy. Rokowanie jest na ogół korzystne -w ciągu kilku tygodni dochodzi do poprawy funkcji skurczowej lewej komory, jednak czasami występują powikłania, takie jak ostra niedomykalność mitralna, dysfunkcja prawej komory, zawężanie drogi odpływu lewej komory, skrzeplina w lewej komorze, ostra niewydolność serca lub wstrząs kardiogenny, które mogą nawet prowadzić do zgonu. Dlatego niezwykle istotne jest znalezienie czynników, które wpływają na rokowanie pacjentów, a które są łatwo i szybko dostępne.Słowa kluczowe: takotsubo, zespół balotującego koniuszka, kardiomiopatia stresowa Cardiologica 2016; 11, 6: 569-574 Folia

show abstract

Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for In-hospital Complications in Patients With Takotsubo Syndrome

et al. 2019

View full text Add to dashboard Cite

IMPORTANCE Takotsubo syndrome (TTS) is an acute, reversible heart failure syndrome featured by significant rates of in-hospital complications. There is a lack of data for risk stratification during hospitalization.OBJECTIVE To derive a simple clinical score for risk prediction of in-hospital complications among patients with TTS. DESIGN, SETTING, AND PARTICIPANTSIn this prognostic study, 1007 consecutive patients were enrolled in the German and Italian Stress Cardiomyopathy (GEIST) registry from July 1, 2007, through December 31, 2017, and identified as the derivation cohort; 946 patients were enrolled in the Spanish Registry for Takotsubo Cardiomyopathy (RETAKO) as the external score validation. An admission risk score was developed using a stepwise multivariable regression analysis from 2 registries. Data analysis was performed from March 1, 2018, through July 31, 2018. MAIN OUTCOMES AND MEASURESIn-hospital complications were defined as death, pulmonary edema, need for invasive ventilation, and cardiogenic shock. Four variables were identified as independent predictors of in-hospital complications and were used for the score: male sex, history of neurologic disorder, right ventricular involvement, and left ventricular ejection fraction (LVEF). RESULTSOf the 1007 patients enrolled in the GEIST registry, 107 (10.6%) were male, with mean (SD) age of 69.8 (11.4) years. Overall rate of in-hospital complications was 23.3% (235 of 1007) (death, 4.0%; pulmonary edema, 5.8%; invasive ventilation, 6.4%; and cardiogenic shock, 9.1%). The GEIST prognosis score was derived by providing 20 points each for male sex and history of neurologic disorders and 30 points for right ventricular involvement and then subtracting the value in percent of LVEF (decimal values between 0.15 and 0.70). Score accuracy on area under the receiver operating characteristic curve analysis was 0.71, with a negative predictive power of 87% with scores less than 20. External validation in the RETAKO population (124 [13.1%] male; mean [SD] age, 69.5 [14.9] years) revealed an area under the curve of 0.73 (P = .46 vs GEIST xderivation cohort). Stratification into 3 risk groups (<20, 20-40, and >40 points) classified 316 patients (40.9%) as having low risk; 342 (44.3%) as having intermediate risk, and 114 (14.8%) as having high risk of complications. The observed in-hospital complication rates were 12.7% for low-risk patients, 23.4% for intermediate-risk patients, and 58.8% for high-risk patients (P< .001 for trend). After 2.6 years of follow-up, patients with in-hospital complications had significantly higher rates of mortality than those without complications (40% vs 10%, P = .01). CONCLUSIONS AND RELEVANCEThe GEIST prognostic score may be useful in early risk stratification for TTS. High-risk patients with TTS may require an intensive care unit stay, and low-risk patients with TTS could be discharged within a few days. In-hospital complications in patients with TTS may be associated with increased risk of long-term mortality.

show abstract

In-hospital mortality among patients with takotsubo cardiomyopathy: A study of the National Inpatient Sample 2008 to 2009

Cited by 273 publications

References 23 publications

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Estimation of Risk Factors for Cardiogenic Shock in Takotsubo Cardiomyopathy: A Retrospective Study

Parametry echokardiograficzne wpływające na rokowanie pacjentów z kardiomiopatią takotsubo

Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for In-hospital Complications in Patients With Takotsubo Syndrome

Contact Info

Product

Resources

About