Mesotrione is a selective herbicide used for preemergence and postemergence weed control in corn. A better understanding of the interactions between mesotrione and soil insecticides is needed to avoid risk of serious corn injury. Field trials were conducted to examine corn injury from mesotrione applied postemergence as affected by insecticide type, application method, and application rate. Corn injury from mesotrione applied postemergence at 0.19 lb ai/acre was 34, 19, and 13% in corn treated with terbufos, chlorpyrifos, and tefluthrin, respectively. In a separate study, corn injury was greater in corn treated with terbufos than clorpyrifos. Injury from mesotrione increased when terbufos was applied at two times the typical rate. Corn injury was higher when terbufos was applied in‐furrow versus T‐band. In each study, corn recovered rapidly from mesotrione injury with no reduction in corn yield. The extent of corn injury observed in these trials indicate that the combination of foliar‐applied mesotrione following soil‐applied terbufos should be avoided.