In-flow detection of ultra-small magnetic particles by an integrated giant magnetic impedance sensor

Fodil, Kamel; Denoual, Matthieu; Dolabdjian, Christophe; Treizebré, A.; Senez, V.

doi:10.1063/1.4948286

Cited by 32 publications

(17 citation statements)

References 60 publications

(56 reference statements)

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“…After the introduction of magnetic biosensors by Baselt et al [ 22 ] in 1998, magnetic particle based magneto-resistive sensor principles have been extended to resonance sensors [ 23 , 24 , 25 , 26 ], fluxgate sensors [ 27 , 28 ], hall effect sensors [ 29 , 30 , 31 , 32 ], magneto-resistance sensors [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ], spin valve sensors [ 40 , 41 , 42 , 43 ], and anisotropic magneto-resistance sensors [ 44 , 45 , 46 ]. However, MI effect sensors have received great attention in sensing of biological magnetic fields.…”

Section: Introductionmentioning

confidence: 99%

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

Sayad

Skafidas

Kwan

2020

Sensors

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Biosensors based on magneto-impedance (MI) effect are powerful tools for biomedical applications as they are highly sensitive, stable, exhibit fast response, small in size, and have low hysteresis and power consumption. However, the performance of these biosensors is influenced by a variety of factors, including the design, geometry, materials and fabrication procedures. Other less appreciated factors influencing the MI effect include measuring circuit implementation, the material used for construction, geometry of the thin film sensing element, and patterning shapes compatible with the interface microelectronic circuitry. The type magnetic (ferrofluid, Dynabeads, and nanoparticles) and size of the particles, the magnetic particle concentration, magnetic field strength and stray magnetic fields can also affect the sensor sensitivity. Based on these considerations it is proposed that ideal MI biosensor sensitivity could be achieved when the sensor is constructed in sandwich thick magnetic layers with large sensing area in a meander shape, measured with circuitry that provides the lowest possible external inductance at high frequencies, enclosed by a protective layer between magnetic particles and sensing element, and perpendicularly magnetized when detecting high-concentration of magnetic particles.

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Section: Introductionmentioning

confidence: 99%

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

Sayad

Skafidas

Kwan

2020

Sensors

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“…Several methods of magnetic detection have been proposed based on magnetic resonance effect, susceptibility measurements, giant magnetoimpedance (GMI), Hall Effect, Tunnel Magneto Resistance effect (TMR) or Giant Magneto Resistance effect (GMR) [24,39,40,41,42,43,44]. As biological objects are not magnetic and cannot be detected alone using magnetic sensors, the target must first be bound to magnetic particles (MPs or beads).…”

Section: Introductionmentioning

confidence: 99%

“…In a typical magnetic detection process, the mixture of the sample and mAbs-coated MPs is introduced into a microchannel where it flows above the sensors that detect the passage of magnetically labeled biological objects. Several groups worked with GMI sensors, using superparamagnetic particles and Helmoltz coils to generate the AC signal [42,43]. The use of GMR sensors is also a convenient choice for small objects detection due to their high sensitivity and their ease of production [25,39,47,48,49,50].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In-Flow Magnetoresistive Chip Cell—Counter as a Diagnostic Tool

et al. 2019

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Inexpensive simple medical devices allowing fast and reliable counting of whole cells are of interest for diagnosis and treatment monitoring. Magnetic-based labs on a chip are one of the possibilities currently studied to address this issue. Giant magnetoresistance (GMR) sensors offer both great sensitivity and device integrability with microfluidics and electronics. When used on a dynamic system, GMR-based biochips are able to detect magnetically labeled individual cells. In this article, a rigorous evaluation of the main characteristics of this magnetic medical device (specificity, sensitivity, time of use and variability) are presented and compared to those of both an ELISA test and a conventional flow cytometer, using an eukaryotic malignant cell line model in physiological conditions (NS1 murine cells in phosphate buffer saline). We describe a proof of specificity of a GMR sensor detection of magnetically labeled cells. The limit of detection of the actual system was shown to be similar to the ELISA one and 10 times higher than the cytometer one.

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“…There is no inconvenient, in principle, in using thin film sensors substituting magnetic wires in the set-up described in Ref. [76].…”

Section: Brief Survey Of Applicationsmentioning

confidence: 99%

Thin-Film Magneto-Impedance Sensors

Garcı́a-Arribas¹,

Férnández²,

Cos³

2017

Magnetic Sensors - Development Trends and Applications

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We review the state-of-the-art of thin films displaying the magneto-impedance (MI) effect, with focus on the aspects that are relevant to the successful design and operation of thin film-based magnetic sensors. After a brief introduction of the MI effect, the materials and geometries that maximize the performance, together with the measurement procedure for their characterization, are exposed. A nonexhaustive survey of applications is included, mostly with the aim of displaying the capabilities of thin film structures in the field of magnetic sensing, and the variety of topics covered by them. A special emphasis is made on some concepts that are not commonly treated in the literature, such as the influence of the measuring circuit on the magneto-impedance ratio, the geometry optimization by means of numerical simulation by finite element methods, or noise measurements on thin films. Additionally, a brief description of the patterning procedure by photolithography is included, since the major advantage of thin film sensors over other types of magneto-impedance materials as ribbons or wires is the possibility of patterning the sensible element in micrometric shapes, and most of all, their easy integration with the interface microelectronic circuitry.

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In-flow detection of ultra-small magnetic particles by an integrated giant magnetic impedance sensor

Cited by 32 publications

References 60 publications

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

Magneto-Impedance Biosensor Sensitivity: Effect and Enhancement

Evaluation of In-Flow Magnetoresistive Chip Cell—Counter as a Diagnostic Tool

Thin-Film Magneto-Impedance Sensors

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