In favour of the definition "adolescents with idiopathic scoliosis": juvenile and adolescent idiopathic scoliosis braced after ten years of age, do not show different end results. SOSORT award winner 2014

Donzelli, Sabrina; Zaina, Fabio; Lusini, Monia; Minnella, Salvatore; Négrini, Stefano

doi:10.1186/1748-7161-9-7

Cited by 14 publications

(10 citation statements)

References 36 publications

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“…The etiology of AIS has a strong genetic component [13, 18, 33], with different patterns of inheritance [37, 47]. Additionally, multiple non-genetic causes have been associated with the development of AIS [13].…”

Section: Introductionmentioning

confidence: 99%

“…The quality of life and treatment satisfaction of the patient with AIS undergoing bracing is a subject of interest in the international literature [1, 10–15, 17–19, 25, 48, 49, 55, 57, 59–63, 76–78, 86]. The natural course of AIS has been found to be extremely variable [12, 13, 18, 33, 60–62], and the effectivity rate of bracing treatment has historically been difficult to quantify. Nevertheless, bracing has been shown to be an effective non-surgical treatment method in different studies [1, 44–46].…”

Section: Introductionmentioning

confidence: 99%

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Quality of life and patient satisfaction in bracing treatment of adolescent idiopathic scoliosis

et al. 2018

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BackgroundBracing is used as a valid non-surgical treatment for adolescent idiopathic scoliosis (AIS) to avoid progression of the deformity and thereby surgery. The effect of bracing treatment on quality of life of patients with AIS has been a topic of interest in the international literature. The aim of this study was to evaluate the quality of life and patient satisfaction during bracing treatment for AIS of a pediatric hospital.Material and methodWe assessed a total of 43 non-consecutive female patients (mean age at questionnaire, 13 years and 1 month and 10 years and 8 months to 14 years and 5 months; mean period of usage of brace, 1 year and 7 months), with adolescent idiopathic scoliosis (AIS), older than 10 years of age until skeletal maturity, with a Risser sign less than 3 and scoliosis between 20 and 45°, treated with thoracolumbosacral orthosis (TLSO) for a period longer than 6 months, and without other comorbidities or previous surgeries, were evaluated. The patients were administered a previously validated to Spanish questionnaire on quality of life (Brace Questionnaire (BrQ); Grivas TB et al.). BrQ is a validated tool and is considered a disease-specific instrument; its score ranges from 20 to 100 points, and higher BrQ scores are associated with better quality of life.ResultsThe patients reported using the brace for a mean of 17.6 h daily and for a mean period of 1 year and 7 months at the time of the study. Overall, 72% of the study population reported to be in some way psychologically affected by the brace wearing, 56% felt their basic motor activities were affected, 54% felt socialization with their environment was affected, 46% considered their quality of life deteriorated due to pain, and 40% reported conflicts in the school environment.ConclusionPatients with AIS treated with bracing reported a negative impact (53.5% overall) on quality of life and treatment satisfaction in terms of psychological, motor, social, and school environment aspects. An interdisciplinary approach would be important for the integrated psychosocial care of these patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality of life and patient satisfaction in bracing treatment of adolescent idiopathic scoliosis

et al. 2018

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“…Moreover, 32 out of 125 patients in their study initiated brace treatment during adolescence. According to Donzelli et al [ 28 ], patients diagnosed during the juvenile period but braced later, during adolescence, can be considered, in terms of prognosis, as adolescent scoliosis. It is true that, like us, they did not find age differences in successful and unsuccessful patients, but rather a higher pre-brace Cobb angle was observed in those failing.…”

Section: Discussionmentioning

confidence: 99%

“…The Cobb angle at baseline was 31° (20–71). According to Donzelli et al [ 28 ], the response to bracing in patients diagnosed with JIS according to the SRS (from 3 years to 9 years and 11 months) but starting bracing at 10 years of age or later is not different to those diagnosed with AIS. Thus, we could expect a response similar to that of children with very early AIS in the Khoshbin et al study (initiation of bracing and pre-brace curve magnitude), and, knowing that bracing is dose dependent in AIS [ 14 ], the high incidence of final surgery should be no surprise, considering a compliance under 50%.…”

Section: Discussionmentioning

confidence: 99%

Evolution of Early Onset Scoliosis under Treatment with a 3D-Brace Concept

Sauvagnac¹,

Rigo²

2022

JCM

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The objective of this study is to examine the evolution of all the braced patients diagnosed with early onset scoliosis in a private scoliosis center. All patients diagnosed with EOS and braced before the age of ten were retrospectively reviewed. The results have been defined in accordance with the Scoliosis Research Society (SRS) for bracing criteria, and with a minimum follow-up of one year. Improvement and stabilization were considered successful treatments, while failure was considered to be an unsuccessful treatment. Successful results were observed in 80% of patients (63% worst case). In the success group, the Cobb angle was reduced from 36.3° (21–68) to 25° (10–43), with 36% of patients being initially treated only with night-time bracing. Twenty percent of the patients failed, seven had more than 45° at the last control and five had undergone surgery. This study suggests that bracing, using a modern 3D-brace concept, could be an effective treatment option for early onset scoliosis and advocates exploring its effectiveness as an alternative to casting throughout studies of higher levels of evidence.

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“…It is characterized by an abnormal three-dimensional curvature of the spine with an onset that can occur between birth and sexual maturity. Thus, it has been classified as infantile, juvenile, or adolescent based on when a curve is initiated 2 . Adolescent Idiopathic Scoliosis (AIS) represents the most common form of scoliosis and occurs between the ages of 10 and 15 years, with girls affected more severely than boys 3 .…”

Section: Introductionmentioning

confidence: 99%

Association of Circulating YKL-40 Levels and CHI3L1 Variants with the Risk of Spinal Deformity Progression in Adolescent Idiopathic Scoliosis

Nada

Julien

Rompré

et al. 2019

Sci Rep

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The cellular and molecular mechanisms underlying spinal deformity progression in adolescent idiopathic scoliosis (AIS) remain poorly understood. In this study, 804 French-Canadian patients and 278 age- and sex-matched controls were enrolled and genotyped for 12 single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 ( CHI3L1 ) gene or its promoter. The plasma YKL-40 levels were determined by ELISA. We showed that elevation of circulating YKL-40 levels was correlated with a reduction of spinal deformity progression risk. We further identified significant associations of multiple CHI3L1 SNPs and their haplotypes with plasma YKL-40 levels and scoliosis severity as a function of their classification in a specific endophenotype. In the endophenotype FG3 group, we found that patients harboring the haplotype G-G-A-G-G-A (rs880633|rs1538372|rs4950881|rs10399805|rs6691378|rs946261), which presented in 48% of the cases, showed a positive correlation with the plasma YKL-40 levels ( P = 7.6 × 10 −6 and coefficient = 36). Conversely, the haplotype A-A-G-G-G-G, which presented in 15% of the analyzed subjects, showed a strong negative association with the plasma YKL-40 levels ( P = 2 × 10 −9 and coefficient = −9.56). We found that this haplotype showed the strongest association with AIS patients in endophenotype FG2 ( P = 9.9 × 10 −6 and coefficient = −13.53), who more often develop severe scoliosis compared to those classified in the other two endophenotypes. Of note, it showed stronger association in females ( P = 1.6 × 10 −7 and coefficient = −10.08) than males ( P = 0.0021 and coefficient = −9.01). At the functional level, we showed that YKL-40 treatments rescued Gi-coupled receptor signalling dysfunction occurring in primary AIS osteoblasts. Collectively, our findings reveal a novel role for YKL-40 in AIS pathogenesis and a new molecular mechanism interfering with spinal deformity progression.

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In favour of the definition "adolescents with idiopathic scoliosis": juvenile and adolescent idiopathic scoliosis braced after ten years of age, do not show different end results. SOSORT award winner 2014

Cited by 14 publications

References 36 publications

Quality of life and patient satisfaction in bracing treatment of adolescent idiopathic scoliosis

Quality of life and patient satisfaction in bracing treatment of adolescent idiopathic scoliosis

Evolution of Early Onset Scoliosis under Treatment with a 3D-Brace Concept

Association of Circulating YKL-40 Levels and CHI3L1 Variants with the Risk of Spinal Deformity Progression in Adolescent Idiopathic Scoliosis

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