In-depth study of MPV17: a molecular travel unveiling a mitochondrial calcium regulation function
Sébastien Meurant,
Ilario Amato,
Lorris Mauclet
et al.
Abstract:Mitochondrial DNA depletion syndromes are severe genetic disorders associated with mutations in a variety of genes including MPV17, encoding a protein of the inner mitochondrial membrane with an unclear function. In this study, using BioID technology, we identified MPV17 interacting partners among which proteins from the MICOS complex. However, MPV17 knockout did not impact mitochondrial ultrastructure, but led to increased mitochondria-derived vesicles formation and altered mitochondrial permeability transiti… Show more
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