In‐depth prospection of Avène Thermal Spring Water reveals an uncommon and stable microbial community

Bourrain, Muriel; Suzuki, Marcelino T.; Calvez, A; West, Nyree J.; Lions, Julie

doi:10.1111/jdv.16599

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Such observations were made by Bourrain et al . [ 22 ] and Fasesan et al . [ 97 ] in recent years, with both groups pointing out that as-yet-undescribed taxa constitute a stable part of the microbial community in heavily used thermal waters.…”

Section: Discussionmentioning

confidence: 99%

“…Underground water systems are ubiquitous and can serve as an insight into the subsurface microscopic world [ 17 ]. Their investigation provides an opportunity to uncover unique prokaryotic taxa in many places on Earth [ 18 – 22 ]. Amongst the most renowned localities are the hot springs of Yellowstone National Park, where culture-independent analyses have discovered numerous hitherto uncultured microorganisms, mostly novel clades of Archaea [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Prokaryotes of renowned Karlovy Vary (Carlsbad) thermal springs: phylogenetic and cultivation analysis

Smrhova

Jani

Pajer

et al. 2022

Environmental Microbiome

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Background The extreme conditions of thermal springs constitute a unique aquatic habitat characterized by low nutrient contents and the absence of human impacts on the microbial community composition. Thus, these springs may host phylogenetically novel microorganisms with potential use in biotechnology. With this hypothesis in mind, we examined the microbial composition of four thermal springs of the world-renowned spa town of Karlovy Vary (Carlsbad), Czechia, which differ in their temperature and chemical composition. Results Microbial profiling using 16S rRNA gene sequencing revealed the presence of phylogenetically novel taxa at various taxonomic levels, spanning from genera to phyla. Many sequences belonged to novel classes within the phyla Hydrothermae, Altiarchaeota, Verrucomicrobia, and TA06. Cultivation-based methods employing oligotrophic media resulted in the isolation of 44 unique bacterial isolates. These include strains that withstand concentrations of up to 12% NaClw/v in cultivation media or survive a temperature of 100 °C, as well as hitherto uncultured bacterial species belonging to the genera Thermomonas, Paenibacillus, and Cellulomonas. These isolates harbored stress response genes that allow them to thrive in the extreme environment of thermal springs. Conclusions Our study is the first to analyze the overall microbial community composition of the renowned Karlovy Vary thermal springs. We provide insight into yet another level of uniqueness of these springs. In addition to their unique health benefits and cultural significance, we demonstrate that these springs harbor phylogenetically distinct microorganisms with unusual life strategies. Our findings open up avenues for future research with the promise of a deeper understanding of the metabolic potential of these microorganisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prokaryotes of renowned Karlovy Vary (Carlsbad) thermal springs: phylogenetic and cultivation analysis

Smrhova

Jani

Pajer

et al. 2022

Environmental Microbiome

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“…The dysbalance of the skin microbiome can lead to an altered immune system, which can lead to inflammatory diseases of the skin. In Avène Thermal Spring Water were isolated 39 phylia (mainly Nitrospirae and Proteobacteria ) [ 38 ]. The mud can affect the microbiology of the skin, which has a beneficial effect on immune function (5 in vitro studies so far).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Lakitelek Thermal Water and Tap Water on Skin Microbiome, a Randomized Control Pilot Study

Bender¹,

Gabriella²,

Kristóf³

et al. 2023

Life

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The beneficial effects of balneotherapy have been proven by numerous clinical studies on locomotor disorders. To date, there is only scant data on changes in the microbiome system of the skin during balneotherapy. The aim of this study was to compare the effects of thermal water and tap water on the skin’s microbiome in healthy volunteers. 30 healthy female volunteers participated in the study. The experimental group (of 15 women) spent 30-min 10 times, in Gabriella Spring’s thermal baths (i.e., mineral water containing sodium hydrogen carbonate).The controlled group (15 women) had the same, but in tap water. The results of this study have proven that there is a difference in the influencing effects of tap water and medicinal water on the microbiome of the skin. After bathing in the thermal water of Lakitelek, Deinococcus increased significantly at the genus level, and the tendency for Rothia mucilaginosa bacteria also increased. At the species level, Rothia mucilaginosa increased significantly, while Paracoccus aminovorans and the tendency for Paracoccus marcusii decreased. When the values of the two trial groups after bathing at the genus level were compared, Rothia bacteria increased significantly, while Haemophilus tended to increase, Pseudomonas tended to decrease, Neisseria tended to increase significantly, and Flavobacterium tended to decrease. At the species level, Geobacillus vulcani decreased significantly, and the tendency for Burkholderia gladioli decreased. The growth of Rothia mucilaginosa and the decrease in the tendency of Paracoccus, Pseudomonas, Flavobacteroium, and Burkholderia gladioli confirm the beneficial effect of balneotherapy. In this study, trends are represented by the uncorrected p value. The main result was that the thermal water changed certain bacteria of the skin, both on the genus and species levels, but there were no significant changes in the tap water used, either at the genus or species level. We first compared the worlds of thermal water and tap water’s microbiome systems. The thermal water decreased the number of certain inflammatory infectious agents and could enhance some of their positive effects, which have been proven at the molecular level. Our results can provide an important clue in the treatment of certain skin diseases. The research of the skin microbiome during balneotherapy can be one of the most intriguing and exciting topics of the future and can bring us closer to understanding the mechanism of action of balneotherapy.

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“…Bourrain et al [84] studied the structure of skin microbiome in patients with atopic dermatitis and its changes during an 18-day course of hydrotherapy with Avène spring water, finding that the number of lesional sites colonized by S. aureus, and the SCORAD index were significantly reduced, mainly in inflammatory and moist areas, promoting the emergence of a diversified microflora [83]. Later on, the same research group studied the microbial diversity of this thermal spring water and concluded that bacteria were distributed into 39 phyla, with Nitrospirae and Proteobacteria as the most prevalent.…”

Section: Thermal Spring Waters Microbiomementioning

confidence: 99%

Hydrobiome of Thermal Waters: Potential Use in Dermocosmetics

2023

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Over the course of the last 20 years, numerous studies have identified the benefits of thermal waters on different skin conditions. Consequently, several investigations have been carried out on their effects on the skin, which are linked to their chemical composition, and, recently, scientists have turned their attention to the role of the thermal spring’s microbiota, named “hydrobiome”, regarding these therapeutic effects. At the same time, the development of cosmetics based on pre, pro, and postbiotics has reached great relevance and research is increasing every day. This review gathers information on the biological diversity of thermal spring waters and their potential use in obtaining biological compounds, metabolites, or bacterial extracts for use in dermocosmetics as active ingredients. These bioactive compounds are able to improve dermatological diseases such as atopic dermatitis or rosacea and ameliorate pruritus and xerosis; moreover, they can increase protection against UV exposure, strengthen barrier function, maintain good homeostasis of skin defenses, repair damaged skin, promote wound healing, improve skin condition, reduce uneven skin pigmentation, and prevent skin aging. From a future perspective, fruitful cooperation among researchers, hydrologists, thermal spa centers, and cosmetic industries will drive this sector toward a better understanding of the role of the hydrobiome of thermal spring waters on healthy skin and dermatological diseases and consider the inclusion of derivatives of this hydrobiome (in the form of fermenters, lysates, extracts, etc.) in dermocosmetic formulations. Therefore, and being aware of the potential of the hydrobiome in dermatological and skin care applications, the future prospects for the use of bioactive substances derived from it in dermocosmetic formulations are promising.

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In‐depth prospection of Avène Thermal Spring Water reveals an uncommon and stable microbial community

Cited by 9 publications

References 33 publications

Prokaryotes of renowned Karlovy Vary (Carlsbad) thermal springs: phylogenetic and cultivation analysis

Prokaryotes of renowned Karlovy Vary (Carlsbad) thermal springs: phylogenetic and cultivation analysis

The Effects of Lakitelek Thermal Water and Tap Water on Skin Microbiome, a Randomized Control Pilot Study

Hydrobiome of Thermal Waters: Potential Use in Dermocosmetics

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