In-Depth Comparative Assessment of Different Metallic Biomaterials in Simulated Body Fluid

Abstract

Invitro experiments have been conducted on metallic biomaterials used for orthopedic implants in order to determine their behavior when immersed in simulated body fluid (SBF). Thus, 3Ti-based metallic biomaterial samples already available on the marked were purchased and immersed in simulated blood plasma, and kept at 37 °C for 4 months. In-depth characterization consisted of a wide series of structural characterizations of both the samples and SBF. Sample analysis consisted of the following: optical (OM) and scanning electron microscopy (SEM) in order to establish the surface and deep corrosion, mass gain/loss assessment for determining the metallic ions loss and/or protective layer formation, and X-ray diffraction in order to establish if and what kind of layers are formed. SBF analysis consisted of using inductively coupled plasma mass spectroscopy (ICP-MS) in order to establish if and/or how many metallic ions have dissociated from the metallic samples into the SBF, and measurements of pH and electrical conductivity. The key findings of the research are as follows: during the four months while kept in SBF, the samples show surface corrosion degradation and protective layer generation. Also, the amount of metallic ions dissociated into the SBF is making them suitable for use. Taking into account that it is highly improbable for such a large area of metal as the one considered within this work to be exposed to real body fluids and that all the samples have developed protective oxide films, the overall conclusion is that they are appropriate for implant use.

Electrochemical Behaviour of Ti and Ti-6Al-4V Alloy in Phosphate Buffered Saline Solution

“…[6]. Therefore, many research types were performed to understand better the corrosion behavior of titanium and its alloys in different simulated body fluids [7][8][9][10][11][12][13][14]. The high corrosion resistance of titanium and its alloys is due to the formation of stable and protective oxide layer (mainly consisting of TiO 2 ) of a thickness of 2-6 nm.…”