In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions

Demuyser, Thomas; Deneyer, Lauren; Bentea, Eduard; Albertini, Giulia; Liefferinge, Joeri Van; Merckx, Ellen; Prins, An De; Bundel, Dimitri De; Massie, Ann; Smolders, Ilse Julia

doi:10.1016/j.physbeh.2015.12.018

Cited by 32 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, increased anxiety-like behavior with no change in basal corticosterone has also been observed in some mouse models [ 83 , 84 ]. While future studies could test for differences between genotypes in corticosterone in response to a stressor [ 84 , 85 ], our results indicate that the enhanced anxiety-like behavior is not secondary to baseline increases in corticosterone.…”

Section: Discussionmentioning

confidence: 80%

Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons

et al. 2018

View full text Add to dashboard Cite

GABAergic dysfunction has been implicated in a variety of neurological and psychiatric disorders, including anxiety disorders. Anxiety disorders are the most common type of psychiatric disorder during adolescence. There is a deficiency of GABAergic transmission in anxiety, and enhancement of GABA transmission through pharmacological means reduces anxiety behaviors. GAD67—the enzyme responsible for GABA production–has been linked to anxiety disorders. One class of GABAergic interneurons, Neuropeptide Y (NPY) expressing cells, is abundantly found in brain regions associated with anxiety and fear learning, including prefrontal cortex, hippocampus and amygdala. Additionally, NPY itself has been shown to have anxiolytic effects, and loss of NPY+ interneurons enhances anxiety behaviors. A previous study showed that knockdown of Gad1 from NPY+ cells led to reduced anxiety behaviors in adult mice. However, the role of GABA release from NPY+ interneurons in adolescent anxiety is unclear. Here we used a transgenic mouse that reduces GAD67 in NPY+ cells (NPYGAD1-TG) through Gad1 knockdown and tested for effects on behavior in adolescent mice. Adolescent NPYGAD1-TG mice showed enhanced anxiety-like behavior and sex-dependent changes in locomotor activity. We also found enhancement in two other innate behavioral tasks, nesting construction and social dominance. In contrast, fear learning was unchanged. Because we saw changes in behavioral tasks dependent upon prefrontal cortex and hippocampus, we investigated the extent of GAD67 knockdown in these regions. Immunohistochemistry revealed a 40% decrease in GAD67 in NPY+ cells in prefrontal cortex, indicating a significant but incomplete knockdown of GAD67. In contrast, there was no decrease in GAD67 in NPY+ cells in hippocampus. Consistent with this, there was no change in inhibitory synaptic transmission in hippocampus. Our results show the behavioral impact of cell-specific interneuron dysfunction and suggest that GABA release by NPY+ cells is important for regulating innate prefrontal cortex-dependent behavior in adolescents.

show abstract

Section: Discussionmentioning

confidence: 80%

Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Anymaze Video Tracking Software (Stoelting, Wood Dale, IL, USA) was used to record distance traveled and percent time in the center of the arena during the single ten-minute trial. The percent of time spent in the center of the arena was calculated as a measure of anxiety-like behavior [42, 43]. …”

Section: Methodsmentioning

confidence: 99%

Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice

Buck

Morris

Weber

et al. 2017

Behavioural Brain Research

View full text Add to dashboard Cite

The neurotoxic effects of methamphetamine (MA) exposure in the developing and adult brain can lead to behavioral alterations and cognitive deficits in adults. Previous increases in the rates of adolescent MA use necessitate that we understand the behavioral and cognitive effects of MA exposure during adolescence on the adolescent brain. Adolescents using MA exhibit high rates of nicotine (NIC) use, but the effects of concurrent MA and NIC in the adolescent brain have not been examined, and it is unknown if NIC mediates any of the effects of MA in the adolescent. In this study, the long-term effects of a neurotoxic dose of MA with or without NIC exposure during early adolescence (postnatal day 30-31) were examined later in adolescence (postnatal day 41-50) in male C57BL/6J mice. Effects on behavioral performance in the open field, Porsolt forced swim test, and conditioned place preference test, and cognitive performance in the novel object recognition test and Morris water maze were assessed. Additionally, the effects of MA and/or NIC on levels of microtubule associated-2 (MAP-2) protein in the nucleus accumbens and plasma corticosterone were examined. MA and NIC exposure during early adolescence separately decreased anxiety-like behavior in the open field test, which was not seen following co-administration of MA/NIC. There was no significant effect of early adolescent MA and/or NIC exposure on the intensity of MAP-2 immunoreactivity in the nucleus accumbens or on plasma corticosterone levels. These results show that early adolescent MA and NIC exposure separately decrease anxiety-like behavior in the open field, and that concurrent MA and NIC exposure does not induce the same behavioral change as either drug alone.

show abstract

“…When the depressed animals showed an increase in immobility time in the TST, they did not produce locomotion changes in the OFT (Millon et al, 2015, Pazini et al, 2015. However, in a number of reports, depressed rodents showed behavioral despair in the TST and decreased locomotor activity in the OFT (Ge et al, 2014, Demuyser et al, 2015, Niu et al, 2015, Yan et al, 2015. The decreased number of crossings or distance moved in 5 min mainly reflected the emotional profile of depressed animals instead of impaired locomotor activity because that the locomotor activity in a long time (30 min) did not changed (Demuyser et al, 2015).…”

Section: -Ht 2a Receptors In Cums-induced Depressive-like Behaviors mentioning

confidence: 97%

Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7

Chen

et al. 2016

Neuropharmacology

View full text Add to dashboard Cite

In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions

Cited by 32 publications

References 38 publications

Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons

Prefrontal cortex-dependent innate behaviors are altered by selective knockdown of Gad1 in neuropeptide Y interneurons

Effects of adolescent methamphetamine and nicotine exposure on behavioral performance and MAP-2 immunoreactivity in the nucleus accumbens of adolescent mice

Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7

Contact Info

Product

Resources

About