In defense of medically supervised doping

Moore, Eric; Morrison, Jo

doi:10.1080/00948705.2022.2066538

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…This heightened training capacity can translate to improved skill development and performance outcomes. 6 Moreover, the psychological boost resulting from these physical improvements can enhance an athlete's self-confidence and self-esteem, which are crucial for optimal performance under pressure. 7 While the potential benefits of AAS are enticing, the negative aspects of their use cannot be overlooked.…”

Section: Introductionmentioning

confidence: 99%

The Uses of Anabolic Androgenic Steroids Among Athletes; Its Positive and Negative Aspects- A Literature Review

Wenbo,

Yan

2023

JMDH

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The use of anabolic androgenic steroids (AAS) for strength training and muscle building is a widespread practice among athletes and young individuals. Athletes and bodybuilders are using these substances for various purposes, such as enhancing muscle mass, strengthening their bodies, and enhancing their performances. AAS exert a wide range of physiological effects that result in the activation of central signaling, resulting in adverse effects. Moreover, excessive use of AAS which can be categorized as AAS abuse; is linked to biological and psychological pathologies, which can lead to mortality. Complications arising from steroid abuse involve both cellular and physiological complications. Cellular complications arise when activation of signaling proteins like mTOR, Akt, etc. leads to alteration in protein synthesis pathways, cell cycle, oxidative stress, and apoptosis, contributing to damage at the cellular level. Physiological complications are evident with cardiovascular pathologies, including an altered lipid profile, cardiac hypertrophy, hypogonadism after discontinuation of AAS, and modulation of GABA receptors in the brain, all contributed by the androgen receptor signaling. Clinical complications budding from these altered physiological processes lead to clinical effects like testicular dysfunction, acne, gynecomastia, and neuropsychiatric disorders. Despite potential therapeutic benefits, AAS use is prohibited by the World Anti-Doping Agency (WADA) due to concerns over adverse health effects. This review highlights the molecular mechanisms, physiological processes, and clinical complications arising from the excessive use of AAS among athletes.

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Section: Introductionmentioning

confidence: 99%