In breast cancer, are treatments and survival the same whatever a patient's age? A population‐based study over the period 1998–2009

Dialla, Pegdwende Olivia; Quipourt, Valérie; Gentil, Julie; Marilier, Sophie; Poillot, Marie‐Laure; Roignot, Patrick; Altwegg, Thierry; Darut-Jouve, Ariane; Guiu, Séverine; Arveux, Patrick; Dabakuyo‐Yonli, Tienhan Sandrine

doi:10.1111/ggi.12327

Cited by 9 publications

(9 citation statements)

References 33 publications

(70 reference statements)

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“…However, when the mortality from other causes than breast cancer has been taken into account in the relative survival, women aged 70 years or more still have a poorer survival than those less than 70 years. These results are consistent with other studies [12,13]. As breast cancers among elderly women are associated with a more favorable tumor biology, more often being hormone receptor positive and human epidermal growth factor receptor-2 negative compared with younger women, the poorer survival is likely to be due to an inferior treatment.…”

Section: Discussionsupporting

confidence: 92%

Trends in breast cancer in the elderly in Denmark, 1980–2012

et al. 2016

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Background Breast cancer is the most frequent malignancy among women worldwide and the second most common cause of cancer-related death in developed countries. The aim of the present analysis is to describe trends in incidence, mortality, prevalence, and relative survival in Denmark from 1980 to 2012 focusing on age, comparing persons aged 70 years or more with those aged less than 70 years. Material and methods Cancer of the breast was defined as ICD-10 code C50. Data derived from the NORDCAN database with comparable data on cancer incidence, mortality, prevalence and relative survival in the Nordic countries, where the Danish data were delivered from the Danish Cancer Registry and the Danish Cause of Death Registry with follow-up for death or emigration until the end of 2013. Results The proportion of patients diagnosed with breast cancer over the age of 70 years increased with time to 29% of women and 44% of men in 2012. Incidence rates increased with time and peaked around 2010 in all age groups except for those aged 90 years or more. Mortality rates were clearly separated by age with increasing mortality rates by increasing age group for both women and men. Relative survival increased over time in all age groups, but patients aged 70 years or more had a poorer relative survival than those aged less than 70 years. In 2012, 58 521 persons (all ages) were alive in Denmark after a diagnosis of breast cancer. Conclusion Poorer survival of Danish breast cancer patients over the age of 70 years is likely to be due to inferior treatment and non-adherence to treatment guidelines. There is a need for clinical trials focusing on patients over the age of 70 years.

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Section: Discussionsupporting

confidence: 92%

Trends in breast cancer in the elderly in Denmark, 1980–2012

et al. 2016

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“…The age finding is consistent with the literature on the survival of women with breast cancer. Several studies (8,(12)(13) shown a difference in survival among young women and women over 50 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…A population-based study in France (13) , showed that the relative survival of women aged <50 years was worse than those aged ≥ 50 years). Young women had a greater chance of being associated with a more aggressive tumor, positive lymph nodes and negative hormonal status, which indicates a worse prognosis of the disease (8) .…”

Section: Discussionmentioning

confidence: 99%

Breast cancer survival in Great Cuiaba, Brazil: a population-based study

Oliveira

Galvão

Pascoa

et al. 2021

Rev. Gaúcha Enferm.

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Objective: To analyze ten-year specific survival of women with breast cancer in Great Cuiaba, Mato Grosso, Brazil. Methods: A population-based cohort of 61 women diagnosed with breast cancer in 2008 and 2009, in Great Cuiabá, Mato Grosso, followed by 2018 in the regional mortality database. Specific survival was analyzed through the Kaplan-Meier curve, with adjustment of the Weibull model and Log-Weibull Regression. The survival curves of the variables were compared using the log-rank test which were statistically significance (p<0.05). Results: The mean time to death is approximately 51.1 months. Women aged ≤ 50 years and of white race/color presented the worst survival. Conclusion: We found out that age, race/color affect specific survival and there is a need for reviewing the control plan for breast cancer in order to increase the survival of women diagnosed with this pathology.

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“…Adjuvant treatment, one of the factors responsible for this trend, is less effective for this stage and age group [ 70 ]. Women older than 70 years also have more comorbidities, and breast-conserving surgery plus adjuvant therapy are used to a lesser extent; both of these factors are related to decreased survival [ 71 ]. In the 85–99 year age group survival increased markedly from 23% in 1985 – 1989 to 62% in 2010 – 2012.…”

Section: Discussionmentioning

confidence: 99%

Trends in incidence, mortality and survival in women with breast cancer from 1985 to 2012 in Granada, Spain: a population-based study

et al. 2018

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BackgroundThe incidence of breast cancer has increased since the 1970s. Despite favorable trends in prognosis, the role of changes in clinical practice and the introduction of screening remain controversial. We examined breast cancer trends to shed light on their determinants.MethodsData were obtained for 8502 new cases of breast cancer in women between 1985 and 2012 from a population-based cancer registry in Granada (southern Spain), and for 2470 breast cancer deaths registered by the Andalusian Institute of Statistics. Joinpoint regression analyses of incidence and mortality rates were obtained. Observed and net survival rates were calculated for 1, 3 and 5 years. The results are reported here for overall survival and survival stratified by age group and tumor stage.ResultsOverall, age-adjusted (European Standard Population) incidence rates increased from 48.0 cases × 100,000 women in 1985–1989 to 83.4 in 2008–2012, with an annual percentage change (APC) of 2.5% (95%CI, 2.1–2.9) for 1985–2012. The greatest increase was in women younger than 40 years (APC 3.5, 95%CI, 2.4–4.8). For 2000–2012 the incidence trend increased only for stage I tumors (APC 3.8, 95%CI, 1.9–5.8). Overall age-adjusted breast cancer mortality decreased (APC − 1, 95%CI, − 1.4 – − 0.5), as did mortality in the 50–69 year age group (APC − 1.3, 95%CI, − 2.2 – − 0.4). Age-standardized net survival increased from 67.5% at 5 years in 1985–1989 to 83.7% in 2010–2012. All age groups younger than 70 years showed a similar evolution. Five-year net survival rates were 96.6% for patients with tumors diagnosed in stage I, 88.2% for stage II, 62.5% for stage III and 23.3% for stage IV.ConclusionsBreast cancer incidence is increasing – a reflection of the evolution of risk factors and increasing diagnostic pressure. After screening was introduced, the incidence of stage I tumors increased, with no decrease in the incidence of more advanced stages. Reductions were seen for overall mortality and mortality in the 50–69 year age group, but no changes were found after screening implementation. Survival trends have evolved favorably except for the 70–84 year age group and for metastatic tumors.

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In breast cancer, are treatments and survival the same whatever a patient's age? A population‐based study over the period 1998–2009

Cited by 9 publications

References 33 publications

Trends in breast cancer in the elderly in Denmark, 1980–2012

Trends in breast cancer in the elderly in Denmark, 1980–2012

Breast cancer survival in Great Cuiaba, Brazil: a population-based study

Trends in incidence, mortality and survival in women with breast cancer from 1985 to 2012 in Granada, Spain: a population-based study

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