In the study of the odd-Z, even-N nuclei 243 Es and 249 Md, performed at the University of Jyväskylä, the fusion-evaporation reactions 197 Au( 48 Ca,2n) 243 Es and 203 Tl( 48 Ca,2n) 249 Md have been used for the first time. Fusion-evaporation residues were selected and detected using the RITU gas-filled separator coupled with the focal-plane spectrometer GREAT. For 243 Es, the recoil decay correlation analysis yielded a half-life of 24 ± 3 s, and a maximum production cross section of 37 ± 10 nb. In the same way, a half-life of 26 ± 1 s, an α branching ratio of 75 ± 5%, and a maximum production cross section of 300 ± 80 nb were determined for 249 Md. The decay properties of 245 Es, the daughter of 249 Md, were also measured: an α branching ratio of 54 ± 7% and a half-life of 65 ± 6 s. Experimental cross sections were compared to the results of calculations performed using the kewpie2 statistical fusion-evaporation code.