In-air hearing of a diving duck: A comparison of psychoacoustic and auditory brainstem response thresholds

Crowell, Sara E.; Wells‐Berlin, Alicia M.; Therrien, Ronald E.; Yannuzzi, Sally E.; Carr, Catherine E.

doi:10.1121/1.4948574

Cited by 16 publications

(7 citation statements)

References 43 publications

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“…5), and (2) wide-field imaging could potentially capture lower auditory thresholds at hearing onset based on responses in higher auditory nuclei than the levels previously considered in the field. In fact, decades of psychoacoustic experiments on humans and animals indicate that behavioral thresholds can be~20-30 dB lower than those measured with the ABR [49][50][51][52] . Therefore, it is possible that central auditory circuits can pick up signals from just a few peripheral neurons through a cascade of amplification and generate activity detectable with calcium imaging while remaining elusive to the ABR.…”

Section: Discussionmentioning

confidence: 99%

Efferent feedback controls bilateral auditory spontaneous activity

et al. 2021

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In the developing auditory system, spontaneous activity generated in the cochleae propagates into the central nervous system to promote circuit formation. The effects of peripheral firing patterns on spontaneous activity in the central auditory system are not well understood. Here, we describe wide-spread bilateral coupling of spontaneous activity that coincides with the period of transient efferent modulation of inner hair cells from the brainstem medial olivocochlear system. Knocking out α9/α10 nicotinic acetylcholine receptors, a requisite part of the efferent pathway, profoundly reduces bilateral correlations. Pharmacological and chemogenetic experiments confirm that the efferent system is necessary for normal bilateral coupling. Moreover, auditory sensitivity at hearing onset is reduced in the absence of pre-hearing efferent modulation. Together, these results demonstrate how afferent and efferent pathways collectively shape spontaneous activity patterns and reveal the important role of efferents in coordinating bilateral spontaneous activity and the emergence of functional responses during the prehearing period.

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Section: Discussionmentioning

confidence: 99%

Efferent feedback controls bilateral auditory spontaneous activity

et al. 2021

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“…The ABR test is a relatively stable, objective hearing examination method that reflects the presence of hearing compensatory function by determining the auditory enhancement (Crowell et al, 2016), as it is not affected by the state of consciousness (awake, comatose, sleeping or anesthetized), making it especially appropriate for anesthetized subjects. To our knowledge, research including this method has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Manganese‐enhanced MR imaging (MEMRI) combined with electrophysiology in the study of cross‐modal plasticity in binocularly blind rats

Tang

Xiao

et al. 2017

Intl J of Devlp Neuroscience

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Our study aimed to determine and verify the establishment of visual to auditory cross-modal plasticity using manganese-enhanced MR imaging (MEMRI) combined with examinations of the visual evoked potential (VEP), auditory brainstem response (ABR) and bilateral visual cortex response to a bilateral auditory stimulus (AVR). Fourteen healthy male Sprague-Dawley newborn rats were randomly divided into 2 groups (n=7 per group). Optic nerve transection was performed in the 7 rats of Group A three weeks after birth to obtain binocularly blind models, and the 7 rats of Group B were maintained as the control group. The VEP was measured to ensure complete binocular blindness. Four months after the operation, MnCl was injected into the left inner ear perilymph of all rats, and an MRI examination was performed 24h after injection. Then, ABR and AVR were measured to detect the generation of auditory compensatory function. The results of the VEP have confirmed complete binocular blindness. The normalized signal intensity of the bilateral medial geniculate nucleus, auditory cortex, visual center (including the lateral geniculate nucleus, superior colliculus and visual cortex) and right hippocampus in binocularly blind rats was significantly increased compared with that in normal rats (P≤0.005), which was confirmed by measurement of the ABR and AVR. Our results suggested that MEMRI combined with electrophysiology can show changes in the auditory and visual pathways of binocularly blind rats and demonstrate the generation of an auditory compensatory pathway.

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“…However, our results did demonstrate that, (1) central auditory responses in the IC can be detected by calcium imaging while only ABR waves I-II were consistently visible at P14.0 ( Figure 5B and 5D), and (2) wide-field imaging could potentially capture lower auditory thresholds at hearing onset based on responses in higher auditory nuclei than the levels previously considered in the field. In fact, decades of psychoacoustic experiments on humans and animals indicate that behavioral thresholds can be ~20-30dB lowers than those measured with the ABR (Ehret, 1977, R.Fay, 1988, Pinto and Matas, 2007, Crowell et al, 2016. Therefore, it is possible that central auditory circuits can pick up signals from just a few peripheral neurons through a cascade of amplification and generate activity detectable with calcium imaging, while remaining elusive to the ABR.…”

Section: Reduced Auditory Sensitivity In the α9/α10 Nachr Knockout Atmentioning

confidence: 99%

Efferent feedback enforces bilateral coupling of spontaneous activity in the developing auditory system

Wang

Sanghvi

Gribizis

et al. 2020

Preprint

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SummaryIn the developing auditory system, spontaneous activity generated in the cochleae propagates into the central nervous system to promote circuit formation before hearing onset. Effects of the evolving peripheral firing pattern on spontaneous activity in the central auditory system are not well understood. Here, we describe the wide-spread bilateral coupling of spontaneous activity that coincides with the period of transient efferent modulation of inner hair cells from the medial olivochlear (MOC) system. Knocking out the α9/α10 nicotinic acetylcholine receptor, a requisite part of the efferent cholinergic pathway, abolishes these bilateral correlations. Pharmacological and chemogenetic experiments confirm that the MOC system is necessary and sufficient to produce the bilateral coupling. Moreover, auditory sensitivity at hearing onset is reduced in the absence of pre-hearing efferent modulation. Together, our results demonstrate how ascending and descending pathways collectively shape spontaneous activity patterns in the auditory system and reveal the essential role of the MOC efferent system in linking otherwise independent streams of bilateral spontaneous activity during the prehearing period.

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In-air hearing of a diving duck: A comparison of psychoacoustic and auditory brainstem response thresholds

Cited by 16 publications

References 43 publications

Efferent feedback controls bilateral auditory spontaneous activity

Efferent feedback controls bilateral auditory spontaneous activity

Manganese‐enhanced MR imaging (MEMRI) combined with electrophysiology in the study of cross‐modal plasticity in binocularly blind rats

Efferent feedback enforces bilateral coupling of spontaneous activity in the developing auditory system

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