In adolescents with epilepsy, high scores of anxiety and depression are associated with occurrence of seizures in public places

Siqueira, Nathália Ferreira; Oliveira, Fernando L. B. B.; Siqueira, Jorge A.; Souza, Elisabete Abib Pedroso de

doi:10.1590/0004-282x20140235

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…Ettinger et al and Baki et al did not find any significant correlation between number of seizures and anxiety and depression scores (11)(12)(13). However, most studies have suggested that affective disturbances are associated with seizure frequency (10,(14)(15)(16). The present findings demonstrate that there is no correlation between affective disturbances and seizure frequency.…”

Section: Discussioncontrasting

confidence: 48%

The Relation of Epilepsy Type with Depression and Anxiety in Children

2021

GMJ

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Objective:The aim of the current study was to determine affective disorders (anxiety and depression) in children with epilepsy and assess the role of epilepsy type. Methods:The study included 56 children with idiopathic generalized epilepsy (26 girls, 30 boys, aged 6-16), 47 children with self-limited focal epilepsy (22 girls, 25 boys, aged 6-16) and 78 healthy age-, gender-, and education matched children (31 girls, 47 boys). Seizure type, seizure frequency, and duration of epilepsy were recorded. All participants completed extensive baseline neuropsychological questionnaires that included Kovac Children's Depression Inventory (CDI) and the State-Trait Anxiety Inventory for Children (STAIc). Results: Children with idiopathic generalized epilepsy had higher depression, state and trait anxiety scores than healthy controls (depression scores: 9.07±7.01 vs 5.20±2.72, p=0.024, state anxiety scores: 37.53±9.34 vs 31.30±6.40, p=0.014, trait anxiety scores: 37.78±9.71 vs 33.23±5.67, p=0.032). Depression, state and trait anxiety scores were significantly higher in children with self-limited focal epilepsy than healthy controls (depression scores: 8.06±4.93 vs 5.20±2.72, p=0.028, state anxiety scores: 37.91±8.21 vs 31.30±5.67, p=0.009, trait anxiety scores: 36.74±9.703 vs 33.23±5.67, p=0.045). We found no significant differences in depression or anxiety scores between idiopathic generalized epilepsy and selflimited focal epilepsy groups. No correlation was found between seizure frequency and scale scores. Conclusion: Our findings bring attention to the increased risks of affective disturbance in pediatric epilepsy. The presence of depression and anxiety in children with epilepsy had no association with epilepsy type and seizure frequency. Therefore, we did not identify epilepsy type as a predictor factor of affective disturbance.

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Section: Discussioncontrasting

confidence: 48%

The Relation of Epilepsy Type with Depression and Anxiety in Children

2021

GMJ

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“…This finding supported reports from other studies. 13,21,22 On the other hand, moderate to severe depression was more common in a study by Pereira and Valente. 23 The difference observed could be due to the study populations.…”

Section: Discussionmentioning

confidence: 92%

Mental Health of Adolescents With Epilepsy in Enugu, Nigeria: A Cross-Sectional Study

Nnajekwu

Ikefuna

et al. 2020

J Child Neurol

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Adolescence is an important period, marked by significant changes in biological and psychosocial domains. Epilepsy is a chronic neurologic disorder associated with social stigma and prejudice. The etiology of depression in epilepsy appears to be a complex interplay between psychosocial and neurobiologic factors. This period may be too taxing for the adolescent with epilepsy to steer, as epilepsy can affect the development of independence by its social, educational, and mental health effects. The study aimed to compare the burden of depression in adolescents with epilepsy with the general population. One hundred forty-five adolescents with epilepsy and their classmates matched for age and gender were studied over a 9-month period. Zung Self-rating Depression Scale was used to determine the burden of depression in the study population. Among the subjects, 70 (48.3%) had scores in the depressive range to varying degrees compared to 38 (26.2%) controls. The difference in scores was significant (OR=2.628, P < .001). Among the population with positive scores, mild depression category was the commonest for both groups (40% and 22.8%, respectively). There was a statistically significant relationship between gender, seizure type, and depression, whereas there was no significant relationship between age, social class, number of antiepileptic drugs, seizure frequency in the last 12 months, and depression. Adolescents with epilepsy had higher rates of depression than the general population. Hence, there might be need for routine screening of adolescents with epilepsy for early detection and management of depression to improve their overall well-being and quality of life.

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“…According to a study by the Department of Neurology at the State University of Campinas (Unicamp), there is no higher incidence of depression or anxiety in the group of teenagers with epilepsy compared to the control group by seeing the diagnostic scores of both [14]. But it was observed that there is a lower frequency of seizures when there are low scores of trait or states of anxiety.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Follow Up of a Patient with De Novo Mutation at Kcna2 Gene Leading to Ataxia and Epileptic Encephalopathy

Vbs

2020

AICS

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Background:The KCNA2 gene codifies a protein of the Kv1.2 potassium channel. Most of the last are express in the central nervous system, where they have an important role in the release of neurotransmitters and neural excitability. A mutation on this gene leads to a drastic over function with the permanent opening of the referred channel.Case presentation: A 13-year-old male child, was diagnosed in 2014 with a mutation on the KCNA2 gene during the investigation of ataxia and epileptic encephalopathy, discovering a new cause of neurodevelopmental disorder. A detailed description of the symptoms of the patient was obtained during his lifetime until the publication of this article. Conclusion:A new cause of neurodevelopmental disorder was found during an investigation of the epileptic encephalopathy and ataxia-the mutation in the KCNA2 gene-, as a detailed evolution of this syndrome.

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In adolescents with epilepsy, high scores of anxiety and depression are associated with occurrence of seizures in public places

Cited by 11 publications

References 17 publications

The Relation of Epilepsy Type with Depression and Anxiety in Children

The Relation of Epilepsy Type with Depression and Anxiety in Children

Mental Health of Adolescents With Epilepsy in Enugu, Nigeria: A Cross-Sectional Study

Case Report: Follow Up of a Patient with De Novo Mutation at Kcna2 Gene Leading to Ataxia and Epileptic Encephalopathy

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