Imputation of plasma lipid species to facilitate integration of lipidomic datasets
Aleksandar Dakic,
Jingqin Wu,
Tingting Wang
et al.
Abstract:Recent advancements in plasma lipidomic profiling methodology have significantly increased specificity and accuracy of lipid measurements. This evolution, driven by improved chromatographic and mass spectrometric resolution of newer platforms, has made it challenging to align datasets created at different times, or on different platforms. Here we present a framework for harmonising such plasma lipidomic datasets with different levels of granularity in their lipid measurements. Our method utilises elastic-net p… Show more
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