There now exists a wealth of experimental evidence that Sr2RuO4 is an odd-parity superconductor. Experiments further indicate that among the bands stemming from the Ru {xy, xz, yz} orbitals, the portion of the Fermi surface arising from the xy orbitals exhibits a much larger gap than the portions of the Fermi surface arising from the {xz, yz} orbitals. In this paper the role of impurities on such an orbital dependent superconducting state is examined within the Born approximation. In contrast to expected results for a nodeless p-wave superconductor the unique nature of the superconducting state in Sr2RuO4 implies that a low concentration of impurities strongly influences the low temperature behavior. 74.20.Mn,74.25.Bt,74.25.Jb Since the discovery of superconductivity in the layered oxide Sr 2 RuO 4 in 1994 [1] and the prediction of odd-parity superconductivity [2] it has been quickly established that the symmetry of the superconducting order parameter is indeed of odd parity. Early NQR [3], tunneling [4], and impurity studies [5] clearly indicated that Sr 2 RuO 4 is not a conventional superconductor. More recently µSr measurements reveal that the superconducting state breaks time reversal symmetry [6] and Knight shift measurements show no change in the spin susceptibility when passing through the superconducting transition [7]. These measurements indicate that the superconducting state is described by a spin-triplet pair amplitude with an orbital dependence η 1 k x + η 2 k y where (η 1 , η 2 ) ∝ (1, i) when no magnetic field is applied. Such a superconducting state is nodeless in a quasi-2D material. The effect of impurities within the Born approximation on a nodeless p-wave state has been well studied [8,9]. The results indicate that impurities do not drastically change the low temperature properties of the superconducting state unless a sufficiently large impurity concentration is present. For Sr 2 RuO 4 the experiments of Nishizaki et al. indicate that impurities strongly alter the low temperature properties even in the small impurity concentration limit [10]. This has previously been interpreted as an indication that Sr 2 RuO 4 is in the unitarity scattering limit [11]. Here it is shown that the Born approximation can explain the experimental results once the the unique microscopic (orbital dependent) nature of the superconducting state in Sr 2 RuO 4 is considered.The superconducting state described above is fully gapped so it is difficult to understand the experimental observation that only approximately half of the Fermi surface exhibited an energy gap [10]. It was suggested that this feature can be understood when the highly planar character and the electronic structure of the Ru ions are considered [12]. The formal valence is Ru 4+ which implies that the electronic properties are due to four electrons in bands described by Wannier functions with Ru d xy , d xz and d yz orbital character. The quasi-2D nature of the electronic dispersion and the different parity under the reflection symmetry σ z (z → −z...