Impurity profiling of Cefteram pivoxil based on Fourier transform ion cyclotron resonance MS

Yue, Yiqiang; Wang, Jiahong; Zhao, Yuqing; Li, Siqi; Han, Jing; Zhang, Yu; Han, Fei

doi:10.1016/j.jpba.2020.113591

Cited by 4 publications

(6 citation statements)

References 27 publications

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“…Similarly, other compounds were putatively identified and the possible structures of 16 chemical constituents were provided in Figure 4. (4, 8, 14, 15, 16, and 19) are dihydromyricetin, dihydroquercetin, myricetin, eriodictyol, quercetin, and kaempferol, respectively Additionally, the chemical formulae of five unknown compounds including compound 7, compound 12, compound 18, compound 20, and compound 21 were deter-mined by using the isotopic fine structure as described in our previous study [36]. However, further study should be carried out to confirm their chemical structure.…”

Section: Identification Of Chemical Constituents In Semen Hoveniaementioning

confidence: 98%

Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry

Zhang

Han

et al. 2021

J of Separation Science

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A method based on high-performance liquid chromatography and Fourier transform-ion cyclotron resonance mass spectrometry was developed to control the quality of Semen Hoveniae. First, the chromatographic fingerprint was established in combination with the chemometrics methods such as similarity analysis, cluster analysis, principal component analysis, and orthogonal partial least squares discriminant analysis to discover the qualitative markers. Then, an highperformance liquid chromatography mass spectrometry method was developed to identify the chemical constituents in Semen Hoveniae. Moreover, the content of dihydromyricetin and dihydroquercetin in Semen Hoveniae were determined by high-performance liquid chromatography. As a result, nine common peaks were assigned in the fingerprints and the similarity of the 13 batch samples varied from 0.425 to 0.993, indicating an obviously different quality. Dihydromyricetin and dihydroquercetin were the main qualitative markers to differ the quality of Semen Hoveniae. Meanwhile, a total of 21 chemical compounds were characterized by high-performance liquid chromatography mass spectrometry and six of them were identified by comparing with information of reference standards. Finally, the content of dihydromyricetin and dihydroquercetin in 13 batch samples varied from 0.824 to 7.499 mg/g and from 0.05941 to 4.258 mg/g , respectively. In conclusion, the methods developed here will provide sufficient qualitative and quantitative information for the quality control of Semen Hoveniae.

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Section: Identification Of Chemical Constituents In Semen Hoveniaementioning

confidence: 98%

Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry

Zhang

Han

et al. 2021

J of Separation Science

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“…IFSs were required to discriminate between elemental compositions as the accurate mass measurements allowed for many possible formulae for the analytes. 61 Troxipide is a therapeutic agent for gastritis and gastric ulcer. 62 Detailed studies concerning metabolites, pharmacokinetics, and mechanism are missing thereby limiting the clinical use of the drug.…”

Section: Further Drug Understandingmentioning

confidence: 99%

“…Thirteen of these impurities were discovered and reported for the first time in this study. IFSs were required to discriminate between elemental compositions as the accurate mass measurements allowed for many possible formulae for the analytes 61 …”

Section: Post‐approval Analyses and Hrms Quantificationmentioning

confidence: 99%

“…From this visual comparison that is only possible using ultra‐high‐resolution MS, the formula of the m/z 610.14921 ion was assigned to (G) [C 22 H 28 N 9 O 8 S 2 ] + . Reprinted with a permission from 61 …”

Section: New Drug Modalities and Hrms Characterizationmentioning

confidence: 99%

“…IFSs were required to discriminate between elemental compositions as the accurate mass measurements allowed for many possible formulae for the analytes. 61 …”

Section: Post‐approval Analyses and Hrms Quantificationmentioning

confidence: 99%

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Advances in high‐resolution mass spectrometry applied to pharmaceuticals in 2020: A whole new age of information

Géhin

Holman

2021

Analytical Science Advances

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Continuous improvements in mass spectrometry (MS) have resulted in the widespread availability and adoption of high‐resolution mass spectrometry (HRMS) across laboratories worldwide. The capabilities and the associated advantages of HRMS make it an invaluable analytical tool for analyte characterization, screening, and quantification methodologies for a wide scope of applications across pharmaceutical development. These applications include drug discovery, product characterizations of both small molecules and novel drug modalities, in vitro and in vivo metabolism studies, post‐approval quality control, and pharmacovigilance. This review gives an overview of the current capabilities of HRMS and its pharmaceutical applications in 2020, and provides a perspective on the future of HRMS within the pharmaceutical industry.

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Characterization of seven new related impurities and forced degradation products of tetracaine hydrochloride and proposal of degradation pathway by UHPLC-Q-TOF-MS

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Luo²,

Qiao-feng³

et al. 2023

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Impurity profiling of Cefteram pivoxil based on Fourier transform ion cyclotron resonance MS

Cited by 4 publications

References 27 publications

Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry

Quality control of Semen Hoveniae by high‐performance liquid chromatography coupled to Fourier transform‐ion cyclotron resonance mass spectrometry

Advances in high‐resolution mass spectrometry applied to pharmaceuticals in 2020: A whole new age of information

Characterization of seven new related impurities and forced degradation products of tetracaine hydrochloride and proposal of degradation pathway by UHPLC-Q-TOF-MS

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