Impulsivity: current and future trends in pharmacological treatment

Braquehais, María Dolores; Ramos-Quiroga, Josep Antoni; Sher, Leo

doi:10.1586/ern.10.100

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Therefore findings in right temporal pole, left temporal pole and left inferior temporal cortex support former studies on the importance of temporal regions in the manifestation of impulsive traits (Gardini et al, 2009;Hanford et al, 2016;Hirjak et al, 2016;Schilling et al, 2012;Schilling et al, 2013b), including general impulsiveness (Lyoo et al, 2006). They also support the evidence that impulsiveness is not exclusively under the control of the prefrontal cortex (Braquehais et al, 2010).…”

Section: Discussionsupporting

confidence: 83%

“…In short, the above-mentioned data suggest that morphological variations in prefrontal regions play a fundamental role in impulsiveness, both in healthy and clinical subjects.However, impulsiveness seems not to be solely under the control of the prefrontal cortex (Braquehais et al, 2010), since temporal regions are also implicated (Hanford et al, 2016;Lyoo et al, 2006 (Guerrero et al, 2016;2018a;2018b) we explored the relationship between the slant of the forehead degree (SFD) and the CT of the entire cortex, an aspect that is yet to be studied.…”

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confidence: 99%

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Correlation between Impulsiveness, Cortical Thickness and Slant of The Forehead in Healthy Adults

Apolo¹

2020

FMCR

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Impulsiveness is a multidimensional psychological construct with high clinical interest because it is a risk factor for several psychiatric disorders. This study was designed to investigate structural correlates of self-reported impulsiveness, measured by using the Short Scale of Impulsive Behaviour, Barratt Impulsiveness Scale and Zuckerman Sensation Seeking Scale V. As a secondary objective, and based on preliminary findings concerning the positive relationship between impulsiveness and the slant of the forehead degrees (SFD), we explore this relationship and the correlation between SFD and cortical thickness (CT) of the entire cortex. From a sample of 48 participants' structural magnetic resonance images, three self-reports measuring impulsiveness and SFD were obtained. CT of the whole cortex was obtained for each participant through Freesurfer. Correlations between impulsiveness and CT and between CT and SFD were analyzed. Correlations between impulsiveness and SFD were also analyzed. Results showed significant adjusted and corrected correlations, both negative and positive, between impulsiveness and CT. Five negative associations with fronto-temporal and occipital areas were found. Of the 15 positive correlations, eight were with the right anterior cingulate cortex and three with left superior frontal gyrus.Positive correlations between 14 impulsiveness scores and SFD were also found. In conclusion, CT in prefrontal and temporal areas influences self-reported impulsiveness in healthy adults. Furthermore, SFD could influence the CT of regions involved in impulsiveness. Finally, we suggest that a higher SFD higher self-reported impulsiveness in healthy adults.

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Section: Discussionsupporting

confidence: 83%

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confidence: 99%

Correlation between Impulsiveness, Cortical Thickness and Slant of The Forehead in Healthy Adults

Apolo¹

2020

FMCR

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“…For example, neurofeedback treatment has been found to have a significant effect on impulsivity in ADHD (43), and a variation of Dialectical Behavior Therapy has been found to reduce impulsive behavior in an incarcerated population (44). In addition, many pharmacological agents can affect impulsivity [see (45) for a review of this literature]. Future research should investigate whether the psychological and psychiatric interventions that have proven effective in treating impulsivity in other disorders can also help to reduce impulsivity and improve quality of life for individuals with BD.…”

Section: Discussionmentioning

confidence: 99%

Quality of life and impulsivity in bipolar disorder

2011

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Objectives Bipolar disorder (BD) is a chronic psychiatric illness that impairs quality of life (QoL) in numerous life domains even when mood symptoms are not present and is characterized by elevated impulsivity. Many of the comorbid conditions that are associated with diminished QoL in BD also involve impulsivity. The objective of this project was to investigate whether impulsivity might mediate the effects of these comorbid conditions on poor QoL. Methods A total of 76 participants diagnosed with bipolar I disorder by the Structured Clinical Interview for DSM-IV Axis I disorders completed the Quality of Life in Bipolar Disorder (QoL-BD) scale, the Barratt Impulsivity Scale (BIS-11), and the Positive Urgency Measure (PUM). Participants were also assessed for comorbid DSM-IV diagnoses of anxiety, substance use, and impulse control disorders. Results Several subscales of the BIS-11 as well as the PUM total score were significantly negatively correlated with overall QoL. PUM total score remained a significant predictor of QoL after controlling for comorbid anxiety, substance use, and impulse control disorders. After controlling for impulsivity, comorbid disorders were no longer significantly related to overall QoL. Conclusions The data support the hypothesis that impulsivity, specifically positive urgency, is highly correlated with QoL in BD. Impulsivity was found to mediate the relation between QoL and several comorbidities in BD. Interventions targeting impulsivity might help to improve QoL in BD.

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“…Indeed, there is no specific drug indicated for impulsivity, even though there is plenty of research evidence supporting its biological basis. Current treatments for ADHD are drugs such as methylphenidate and atomoxetine, which primarily target the catecholamine transmitters, noradrenaline and dopamine (Arnsten, 2006; Braquehais et al, 2010; Wilens, 2006). The serotonergic systems are thought to be dysfunctional in some impulsive behaviours (Chamberlain et al, 2006; Walderhaug et al, 2002; 2008); however, serotonin-specific reuptake inhibitors (SSRI) lack efficacy in ADHD (Fone and Nutt, 2005).…”

Section: Introductionmentioning

confidence: 99%

Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task

2012

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Previous studies have shown that drugs which block the reuptake of catecholamine neurotransmitters improve impulse control in diseases such as attention deficit hyperactivity disorder (ADHD). Serotonin-specific reuptake inhibitors (SSRI) lack efficacy in ADHD and have been linked to increased suicide risk. The present study investigated drugs with affinity for one or more of the monoamine reuptake transporters using the 5-choice serial reaction time task, a model of attention and impulsivity in rodents. We also tested the effects of the alpha(2)-adreoceptor antagonist, idazoxan and novel antidepressant, agomelatine, which both increase cortical noradrenaline concentrations through non-reuptake mechanisms. Improvements in impulse control were observed with venlafaxine, a serotonin and noradrenaline re-uptake inhibitor (SNRI) but not bupropion (dopamine and noradrenaline re-uptake inhibitor). Sibutramine (SNRI) reduced premature responses by ~50% at the highest dose tested but this was not significant. All three of the SSRIs tested reduced premature responding in a dose-dependent manner, although also slowed response and collection latencies. Neither idazoxan nor agomelatine significantly reduced premature responding, suggesting a lack of efficacy at the doses tested. None of the drugs tested improved attention in this task but sibutramine (SNRI), fluoxetine (SSRI) and paroxetine (SSRI) all increased omissions at the highest dose tested. These data suggest that the SNRIs and SSRIs reduce premature responding but tend to be less specific than noradrenaline specific reuptake inhibitors in this model. SSRIs did not induce any specific impairment in impulse control in this model.

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Impulsivity: current and future trends in pharmacological treatment

Cited by 4 publications

References 19 publications

Correlation between Impulsiveness, Cortical Thickness and Slant of The Forehead in Healthy Adults

Correlation between Impulsiveness, Cortical Thickness and Slant of The Forehead in Healthy Adults

Quality of life and impulsivity in bipolar disorder

Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task

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