Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study

Costanza, Alessandra; Rothen, Stéphane; Achab, Sophia; Thorens, Gabriel; Baertschi, Marc; Weber, Kerstin; Canuto, Alessandra; Richard-Lepouriel, Hélène; Perroud, Nader; Zullino, Daniele

doi:10.1007/s11469-020-00259-3

Cited by 44 publications

(49 citation statements)

References 119 publications

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“…The distribution of these diagnoses is consistent with the general prevalence of mental disorder within the Swiss population [35] and, except for SB, with the literature [8,36,37]. The finding related to SB is also in agreement with its general prevalence in Switzerland, which is higher than most European countries [38][39][40]. From a socio-demographic point of view, no significant differences in gender were observed, as previously described [36], but some recent works have reported an excess of male patients [28].…”

Section: Discussionsupporting

confidence: 88%

Who Consult an Adult Psychiatric Emergency Department? Pertinence of Admissions and Opportunities for Telepsychiatry

Costanza

Mazzola²,

Radomska

et al. 2020

Medicina

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Background and Objectives: Psychiatric disorders constitute frequent causes of emergency department (ED) admissions and these rates are increasing. However, referring to ED a whole range of conditions that could or should be dealt with elsewhere is imposing itself as a problematic situation. We aimed: (1) to provide a descriptive picture of the socio-demographic and diagnostic characteristics of the visits among adults at the psychiatric ED; (2) to estimate the clinical pertinence of these visits. Materials and Methods: Retrospective analysis of diagnostic/socio-demographic characteristics and clinical trajectories of patients admitted for a psychiatric condition at the adult psychiatric ED of the University Hospital of Geneva (HUG), Switzerland, during a 6-week timespan. Results: In our sample (n = 763 total admissions for psychiatric conditions; n = 702 for inclusion of patients having received a medical evaluation), depression/anxiety, suicidal behavior (SB), psychotic episode, and substance use disorder (SUD), in descending order, were the most common diagnoses for referral. Patients belonged to younger age groups (≤65 years), had a familial status other than married/in couple, and did not present an unfavorable socio-demographic profile. Concerning the pertinence for a psychiatric ED, primary diagnosis of depression/anxiety is the only variable significantly associated with different grade of degree. By the examination of the patients’ trajectory from admission to discharge, the clinical pertinence for a psychiatric ED admission existed for cases assigned to the Echelle Suisse du Tri (EST®) scale degree 1 (corresponding to most urgent and severe conditions), particularly for diagnoses of depression/anxiety associated with SB, SB as primary or comorbid diagnosis, and psychotic and manic/hypomanic episode. However, diagnoses of depression/anxiety without urgent and severe features (degrees 2, 3, 4) constituted the most frequent mode of presentation. Conclusions: Ambulatory and community-integrated settings could be more appropriate for the majority of patients admitted to adult psychiatric EDs. Moreover, the implementation of telepsychiatry strategies represents a very promising opportunity to offer these patients care continuity, reduce costs and filter the demand for psychiatric ED.

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Section: Discussionsupporting

confidence: 88%

Who Consult an Adult Psychiatric Emergency Department? Pertinence of Admissions and Opportunities for Telepsychiatry

Costanza

Mazzola²,

Radomska

et al. 2020

Medicina

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“…For instance, the location of the tumors might have an important role in determining the risk for suicidality development. While suicide has been reported in sporadic cases of tumors of different nervous tissue origins [ 17 , 18 , 19 , 20 ], patients with lesions in the frontal lobe have a greater probability to develop SI [ 21 , 22 , 23 , 24 , 25 ]. Consistent with previous studies, the patient described in this report had a tumor in the left frontoparietal lobe, which was accompanied by SI.…”

Section: Discussionmentioning

confidence: 99%

Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar

et al. 2020

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Background: Suicidality and brain tumors are two life-threatening conditions and, somewhat unexpectedly, the associations between them have scarcely been reported. Objective: In this study, we aimed to provide a brief literature review of epidemiological studies on suicidal ideation (SI) and suicidal behavior (SB) in patients with brain tumors. To illustrate various aspects of brain tumors that potentially underlie the emergence of suicidality, the review is supplemented with a clinical exemplar of a long-term survivor of brain tumor (glioblastoma) who experienced persistent SI. Furthermore, we discuss putative both neurobiological (including anatomical and immunological) and psychosocial mechanisms that might be accountable for the development of SI and SB in patients with brain tumors. Conclusions: While the etiology of this phenomenon appears to be multifactorial and still remains a subject of much debate, it is of critical importance to identify patients for which a psychiatric evaluation could recognize, in a timely manner, a possible suicide risk and alleviate the deep related suffering, by appropriate psychopharmacological and supportive and psychotherapeutic interventions.

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“…Nonetheless, having higher scores in negative urgency, in positive urgency, and in (lack of) premeditation – but not in (lack of) perseverance nor in sensation seeking – predicted worst negative alcohol-related consequences. Impulsivity, aggression, and risk-taking – among others – are endophenotypes reported as related to SB and substance use disorders in the literature; however, disentangling pathogenetic hypotheses is difficult ( Costanza et al., 2020 ) and more research is needed. In this regard, our findings on impulsivity-related traits in adolescents help shed light on which endophenotypes may be related to depression, anxiety, and suicidal risk, on the one hand, and which could be related to alcohol drinking, on the other.…”

Section: Discussionmentioning

confidence: 99%

“…In adolescents, some impulsivity-related traits have been found as linked to externalizing behaviors, e.g., substance abuse, antisocial behavior, and aggression ( Carlson et al., 2012 ; Maneiro et al., 2017 ; Stautz and Cooper, 2013 ), alcohol use ( Coskunpinar et al., 2013 ; Stautz and Cooper, 2013 ), and suicidal risk, alongside depressive ( d’Acremont and Van der Linden, 2007 ; Klonsky & May, 2010 ; Saddichha and Schuetz, 2014 ) and anxiety disorders ( Moustafa et al., 2017 ). However, pathogenetic hypotheses that link impulsivity, aggression, substance abuse, and suicidal behavior are difficult to disentangle ( Costanza et al., 2020 ), and studies differ on what traits of impulsivity are significantly related to such behaviors and disorders. This is comprehensible since impulsivity is a psychological construct, which appear, in one form or another, in every major system of personality and plays a main role in the understanding and diagnosis of several forms of mental disorders ( Whiteside and Lynam, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Altitude and latitude variations in trait-impulsivity, depression, anxiety, suicidal risk, and negative alcohol-related consequences in Argentinean adolescents

Steinmetz

Godoy

Fong

2020

Heliyon

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The aims of this research were threefold: 1) to analyze mental health state both general (GMHS, i.e., self-perceived health and psychological distress) and specific (SMHS; i.e., depression, trait-anxiety, negative alcohol-related consequences, and suicidal risk), and impulsivity-related traits (i.e., negative urgency, positive urgency, [lack of] perseverance, [lack of] premeditation, and sensation seeking) in a sample of Argentinean adolescent college students, in function of sex (women, men) and three different altitude-latitude regions (high-north, middle-center, low-south), for identifying common and specific features; 2) to analyze relationships between impulsivity-related traits and indicators of GMHS and SMHS, in the entire sample and in each altitude-latitude region, for understanding the importance of impulsivity-related traits in these forms of mental disorders; and 3) to analyze bivariate relationships between depression, trait-anxiety, negative alcohol-related consequences, and suicidal risk, in the entire sample and considering the three altitude-latitude regions, for testing two-disorder comorbidities. Scores on impulsivity-related traits differed by sex and by altitude-latitude region. GMHS and SMHS differed by sex but not by altitude-latitude region. Several relationships were found between impulsivity-related traits, GMHS, and SMHS as well as between indicators of SMHS. Some of these relationships were dependent on altitude-latitude regions, and implications of these findings were discussed.

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Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study

Cited by 44 publications

References 119 publications

Who Consult an Adult Psychiatric Emergency Department? Pertinence of Admissions and Opportunities for Telepsychiatry

Who Consult an Adult Psychiatric Emergency Department? Pertinence of Admissions and Opportunities for Telepsychiatry

Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar

Altitude and latitude variations in trait-impulsivity, depression, anxiety, suicidal risk, and negative alcohol-related consequences in Argentinean adolescents

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