Impulsivity and attentional bias as predictors of modafinil treatment outcome for retention and drug use in crack-cocaine dependent patients: Results of a randomised controlled trial

Nuijten, Mascha; Blanken, Peter; Brink, Wim van den; Goudriaan, Anna E.; Hendriks, Vincent M.

doi:10.1177/0269881116645268

Cited by 23 publications

(23 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, (±)MOD was reported to attenuate craving during cocaine withdrawal and decrease smoked cocaine self-administration in humans (Ballon and Feifel, 2006;Dackis et al, 2005;Hart et al, 2008). However, other studies suggest that (±)MOD is not effective in attenuating impulsivity for cocaine-taking and attentional bias in crack-cocaine-dependent patients (Nuijten et al, 2016). In general, (±)MOD has been reported to have low abuse liability (Mereu et al, 2013), but a rare case of dependence was recently reported when a high dose was given (Krishnan and Chary, 2015).…”

Section: Discussionmentioning

confidence: 99%

The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

Zhang

Yang

et al. 2017

Neuropsychopharmacol

View full text Add to dashboard Cite

(±)Modafinil ((±)MOD) and its R-enantiomer (R-modafinil; R-MOD) have been investigated for their potential as treatments for psychostimulant addiction. We recently reported a series of (±)MOD analogs, of which JJC8-016 (N-(2-((bis(4-fluorophenyl)methyl)thio)ethyl)-3-phenylpropan-1-amine) was selected for further development. JJC8-016 and R-MOD were evaluated for binding across ~70 receptors, transporters, and enzymes. Although at a concentration of 10 μM, there were many hits for JJC8-016, binding affinities in the range of its DAT affinity were only observed at the serotonin transporter (SERT), dopamine D-like, and sigma receptors. R-MOD was more selective, but had much lower affinity at the DAT (K=3 μM) than JJC8-016 (K=116 nM). In rats, systemic administration of R-MOD alone (10-30 mg/kg i.p.) dose-dependently increased locomotor activity and electrical brain-stimulation reward, whereas JJC8-016 (10-30 mg/kg i.p.) did not produce these effects. Strikingly, pretreatment with JJC8-016 dose-dependently inhibited cocaine-enhanced locomotion, cocaine self-administration, and cocaine-induced reinstatement of drug-seeking behavior, whereas R-MOD inhibited cocaine-induced reinstatement only at the high dose of 100 mg/kg. Notably, JJC8-016 alone neither altered extracellular dopamine in the nucleus accumbens nor maintained self-administration. It also failed to induce reinstatement of drug-seeking behavior. These findings suggest that JJC8-016 is a unique DAT inhibitor that has no cocaine-like abuse potential by itself. Moreover, pretreatment with JJC8-016 significantly inhibits cocaine-taking and cocaine-seeking behavior likely by interfering with cocaine binding to DAT. In addition, off-target actions may also contribute to its potential therapeutic utility in the treatment of cocaine abuse.

show abstract

Section: Discussionmentioning

confidence: 99%

The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

Zhang

Yang

et al. 2017

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Human and preclinical evidence demonstrates that other illicit substances are linked with neurocognitive deficits in adolescents and young adults, including cocaine ( Cannizzaro et al, 2014 ; Nuijten et al, 2016 ; Kaag et al, 2016 , Kaag et al, 2014 ; Marhe and Franken, 2014 ; Rose-Jacobs et al, 2011 ; Lundqvist, 2010 ; Meade et al, 2015 ; Fernández-Serrano et al, 2010 ; Sim et al, 2007 ; Rahman and Clarke, 2005 ; Kober et al, 2016 ; Verdejo-Garcia et al, 2015 ; Moreno-López et al, 2015 ; Ide et al, 2014 ; Tau et al, 2014 ; Albein-Urios et al, 2014 ; Ernst et al, 2000 ; Mayer et al, 2013 ), methamphetamine ( Buck and Siegel, 2015 ; Cuzen et al, 2015 ; King et al, 2010 ; Scott et al, 2007 ), MDMA or ecstasy ( Medina et al, 2005 ; Medina and Shear, 2007 ; Costa et al, 2014 ; Price et al, 2014 ; Downey et al, 2015 ; Halpern et al, 2011 ; Scholey et al, 2011 ; McCann et al, 2014 , McCann et al, 2008 ; Jager et al, 2008 ; de Win et al, 2008 ), inhalants ( Takagi et al, 2011a , Takagi et al, 2011b , Takagi et al, 2014 ; Scott and Scott, 2012 , Scott and Scott, 2014 ), heroin ( Zeng et al, 2013 ; Lundqvist, 2010 ; Ornstein et al, 2000 ; Fernández-Serrano et al, 2010 ), cathinones ( Albertson et al, 2016 ; Patrick et al, 2016 ), ketamine ( Chen et al, 2015 ; Nagy et al, 2015 ; Tang et al, 2013 ; Sun et al, 2014 ; Morgan et al, 2012a <...>…”

Section: Background and Rationalementioning

confidence: 99%

“…Cocaine and crack cocaine will be measured in total occasions (max use in mg). Follow-up questions on the TLFB ask about typical route of administration (smoking, oral ingestion, intranasal/snorting, injecting subcutaneous, injecting intramuscular, injecting intravenous), how often they inject cocaine, how often they use clean needles, and how often they smoke it ( Nuijten et al, 2016 ; Conti et al, 2014 ; Novak and Kral, 2011 ). Pictures of various types of cocaine products and typical dosing are provided.…”

Section: Abcd Substance Use Battery: Baseline Measuresmentioning

confidence: 99%

“…Human and preclinical evidence demonstrates that other illicit substances are linked with neurocognitive deficits in adolescents and young adults, including cocaine (Cannizzaro et al, 2014; Nuijten et al, 2016; Kaag et al, 2016, 2014; Marhe and Franken, 2014; Rose-Jacobs et al, 2011; Lundqvist, 2010; Meade et al, 2015; Fernández-Serrano et al, 2010; Sim et al, 2007; Rahman and Clarke, 2005; Kober et al, 2016; Verdejo-Garcia et al, 2015; Moreno-López et al, 2015; Ide et al, 2014; Tau et al, 2014; Albein-Urios et al, 2014; Ernst et al, 2000; Mayer et al, 2013), methamphetamine (Buck and Siegel, 2015; Cuzen et al, 2015; King et al, 2010; Scott et al, 2007), MDMA or ecstasy (Medina et al, 2005; Medina and Shear, 2007; Costa et al, 2014; Price et al, 2014; Downey et al, 2015; Halpern et al, 2011; Scholey et al, 2011; McCann et al, 2014, 2008; Jager et al, 2008; de Win et al, 2008), inhalants (Takagi et al, 2011a, 2011b, 2014; Scott and Scott, 2012, 2014), heroin (Zeng et al, 2013; Lundqvist, 2010; Ornstein et al, 2000; Fernández-Serrano et al, 2010), cathinones (Albertson et al, 2016; Patrick et al, 2016), ketamine (Chen et al, 2015; Nagy et al, 2015; Tang et al, 2013; Sun et al, 2014; Morgan et al, 2012a), gamma hydroxybutyrate (Johansson et al, 2014; Sircar et al, 2008; Youn et al, 2015), hallucinogens (lysergic acid diethylamide, phencyclidine, peyote, mescaline, N,N- dimethyltryptamine, alpha-methyltryptamine, or 5-methoxy-N,N-diisopropyltryptamine, psilocybin, or salvia) (Compton et al, 2011; Noworyta-Sokołowska et al, 2016; Graham et al, 2010, 2012; Halpern et al, 2005; Carstairs and Cantrell, 2010; Fickenscher et al, 2006; Mahendran et al, 2016; Ranganathan et al, 2012), and anabolic steroids (Wallin-…”

Section: Background and Rationalementioning

confidence: 99%

See 1 more Smart Citation

Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods

Medina

Sher

Conway

et al. 2018

Developmental Cognitive Neuroscience

268

186

View full text Add to dashboard Cite

One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States.

show abstract

“…a major domain of social cognition) and decision-making domains [15–18]. These cognitive alterations are associated with lack of adherence to treatment, as well as with higher relapse rates and greater difficulties to adapt to demands of social relationships [19–21]. Furthermore, gender represents an additional contributor to differences in clinical outcomes among individuals with CUD [22, 23].…”

Section: Introductionmentioning

confidence: 99%

Cocaine use disorder in females is associated with altered social decision-making: a study with the prisoner’s dilemma and the ultimatum game

et al. 2019

View full text Add to dashboard Cite

Background Chronic cocaine use is associated with cognitive deficits, including poor performance on neuropsychological tasks of memory, executive functions, theory of mind and decision-making. However, the relationship between cocaine use disorder and social decision-making remains unclear. This is particularly relevant given the fact that many cocaine abusers present impairments in social functioning. In this sense, game theory paradigms have been helping to comprehend the behavior of psychiatric patients when they directly engage in social situations, which may better approximate many of their real-life choices. Methods The present study investigated social decision-making in individuals with or without cocaine use disorder, examining their behavior in the Prisoner’s Dilemma and in the Ultimatum Game. Thus, 129 females diagnosed with cocaine use disorder and 55 females with no history of substance abuse were recruited and performed both social decision-making tasks. Additional assessments included information about demographics, patterns of substance consumption and executive function performance. Results Females with cocaine use disorder opted more often to not defect in the Prisoner’s Dilemma, while in the Ultimatum Game they frequently chose to accept the first and unfair offer as responders. These effects were more pronounced within females with long-term history of cocaine use. Associations between cocaine use disorder and altered social decision-making were independent from demographic and executive function variables. Conclusions The influence of cocaine use disorder on social decision-making was detected in both game paradigms, resulting in more cooperative behavior in the Prisoner’s Dilemma and higher acceptance rate of unfair offers in the Ultimatum Game. Further studies should focus on investigating these associations to shed light on the putative biopsychosocial factors underlying the observed effects.

show abstract

Impulsivity and attentional bias as predictors of modafinil treatment outcome for retention and drug use in crack-cocaine dependent patients: Results of a randomised controlled trial

Cited by 23 publications

References 88 publications

The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods

Cocaine use disorder in females is associated with altered social decision-making: a study with the prisoner’s dilemma and the ultimatum game

Contact Info

Product

Resources

About