Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers

Fishbein, Diana H.; Lozovsky, David; Jaffe, Jerome H.

doi:10.1016/0006-3223(89)90293-x

Cited by 145 publications

(64 citation statements)

References 31 publications

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“…On the basis of pre-clinical and clinical data, Soubrié (1986) proposed that a reduction in serotonergic activity facilitates active responses at the expense of behavioral inhibition and can result in impulsive behavior in circumstances where an active response is inappropriate and results in either an aversive event or omission of reinforcement. This is in line with clinical evidence that low levels of 5-HIAA are associated with impulsive behavior in the context of certain psychiatric disorders (eg Coccaro, 1989;Linnoila et al, 1993) and with evidence that neuroendocrine responses to fenfluramine are significantly elevated in substance abusers with higher levels of impulsivity (Fishbein et al, 1989).…”

Section: Introductionsupporting

confidence: 87%

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Morgan

Impallomeni

Pirona

et al. 2005

Neuropsychopharmacol

111

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Section: Introductionsupporting

confidence: 87%

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Morgan

Impallomeni

Pirona

et al. 2005

Neuropsychopharmacol

111

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“…Moreover, a recent report indi cates that humans with inherited monoamine oxidase A (MAO-A) deii.ciency, and therefore presumably an increase in brain serotonin, have increased, rather than decreased, impulsive aggressive behavior (Brunner et al 1993). Finally, it should be noted that personality differences are not simply a confound of drug abuse tendencies, because substance abusers, unlike MDMA users in this study, typically have increased rather than decreased scores on measures of impulsivity (Fishbein et al 1989). …”

Section: Mdma Neurotoxicity In Humans 135mentioning

confidence: 74%

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

McCann¹,

Ridenour

Shaham

et al. 1994

Neuropsychopharmacol

305

174

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(±)3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy"), an increasingly popular recreational drug, is known to damage brain serotonin 5-hydroxytryptamine (5-HT) neurons in experimental animals. Whether MDMA is neurotoxic in humans has not been established. Thirty MDMA users and 28 controls were admitted to a controlled inpatient setting for measurement of biologic and behavioral indexes of central 5-HT function. Outcome measures obtained after at least 2 weeks of drug abstinence included concentrations of monoamine metabolites in cerebrospinal fluid (CSF), prolactin responses to L-tryptophan, nociceptive responses to ischemic pain, and personality characteristics in which 5-HT has been implicated (i.e., impulsivity and aggression). Subjects with a history of MDMA exposure had lower levels of CSF 5-hydroxyindoleacetic acid (the

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“…The inverse relationship between PRL response to fenfluramine and aggressive behavior, however, has not been universally replicated. Fishbein, Lozovsky, and Jaffe (1989) found a positive correlation between PRL response to fenfluramine and self-reported aggressive behavior in substance abusers.…”

Section: Pharmacological Challenge Studiesmentioning

confidence: 79%

The evidence for a neurobiological model of childhood antisocial behavior.

Goozen¹,

Fairchild²,

Snoek³

et al. 2007

Psychological Bulletin

414

393

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Children with persistent antisocial and aggressive behavior are diagnosed as having disruptive behavior disorder. The authors review evidence that antisocial children, and especially those who persist with this behavior as they grow older, have a range of neurobiological characteristics. It is argued that serotonergic functioning and stress-regulating mechanisms are important in explaining individual differences in antisocial behavior. Moreover, low fear of punishment and physiological underactivity may predispose antisocial individuals to seek out stimulation or take risks and may help to explain poor conditioning and socialization. The authors propose a theoretical model highlighting the interplay between neurobiological deficits and cognitive and emotional functioning as mediators of the link between early adversity and antisocial behavior problems in childhood. Implications for intervention programs are discussed.

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Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers

Cited by 145 publications

References 31 publications

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

The evidence for a neurobiological model of childhood antisocial behavior.

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