Impulsiveness, personality traits and executive functioning in patients with juvenile myoclonic epilepsy

Gama, André Peres; Taura, Mariângela; Alonso, Neide Barreira; Sousa, Artur Menezes; Noffs, Maria Helena da Silva; Yacubian, Elza Márcia Targas; Guilhoto, Laura Maria de Figueiredo Ferreira

doi:10.1016/j.seizure.2020.09.029

Cited by 16 publications

(8 citation statements)

References 49 publications

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“…There are also higher rates of anxiety and depression in patients with JME compared with the general population 98,99,101 . Additionally, several studies have documented higher rates of impulsivity, which may lead to social or psychiatric problems 102–104 …”

Section: Juvenile Myoclonic Epilepsymentioning

confidence: 99%

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions

et al. 2022

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In 2017, the International League Against Epilepsy (ILAE) Classification of Epilepsies described the "genetic generalized epilepsies" (GGEs), which contained the "idiopathic generalized epilepsies" (IGEs). The goal of this paper is to delineate the four syndromes comprising the IGEs, namely childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy, and epilepsy with generalized tonic-clonic seizures alone. We provide updated diagnostic criteria for these IGE syndromes determined by the expert consensus opinion of the ILAE's Task Force on Nosology and Definitions (2017-2021) and international external experts outside our Task Force. We incorporate current knowledge from recent advances in genetic, imaging, and electroencephalographic studies, together with current terminology and classification of seizures and epilepsies. Patients that do not fulfill criteria for one of these syndromes, but that have one, or a combination, of the following generalized seizure types: absence, myoclonic, tonic-clonic and myoclonictonic-clonic seizures, with 2.5-5.5 Hz generalized spike-wave should be classified as having GGE. Recognizing these four IGE syndromes as a special grouping among the GGEs is helpful, as they carry prognostic and therapeutic implications.

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Section: Juvenile Myoclonic Epilepsymentioning

confidence: 99%

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions

et al. 2022

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“…Patients with JME develop typically, and intellectual disability is rare ( Wandschneider et al, 2012 ; Iqbal et al, 2015 ; Abarrategui et al, 2018 ; Sezikli et al, 2018 ; Almane et al, 2019 ; Chawla et al, 2021 ). Some cognitive domains might be altered (e.g., executive function), and depression, anxiety, impulsivity, and social or psychiatric problems are common ( Wandschneider et al, 2012 ; de Araujo Filho and Yacubian, 2013 ; Iqbal et al, 2015 ; Abarrategui et al, 2018 ; Sezikli et al, 2018 ; Almane et al, 2019 ; Syvertsen et al, 2019 ; Gama et al, 2020 ; Taura et al, 2020 ; Chawla et al, 2021 ). JME is responsive to anti-seizure medications in 65–92% of patients, though it often requires lifelong treatment ( Yacubian, 2017 ; see Table 1 ).…”

Section: Key Features Of Idiopathic Generalized Epilepsies (Iges)mentioning

confidence: 99%

Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets

Lindquist

Timbie

Voskobiynyk

et al. 2023

Neurobiology of Disease

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“…Impulsivity is not a singular concept, rather it encompasses a broad range of actions that are poorly conceived, prematurely expressed, unduly risky, or inappropriate to the situation and it often leads to undesirable outcomes ( 9 , 10 ). In patients with epilepsy, heightened impulsivity not only contributes to poor social adaptability, but also renders individuals more susceptible to various seizure-inducing factors, such as substance abuse, sleep deprivation, and nonadherence ( 7 , 8 , 11 , 12 ). Additionally, studies have reported a positive correlation between high impulsivity and suicidality in patients with epilepsy ( 4 , 5 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…Studies on impulsivity of epilepsy patients have primarily focused on juvenile myoclonic epilepsy, yielding a virtually consistent conclusion of increased impulsivity ( 6 , 11 , 14–18 ). Findings of studies on MTLE patients have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory control deficits in patients with mesial temporal lobe epilepsy: an event-related potential analysis based on Go/NoGo task

Shao,

Li,

Zhang

et al. 2024

Front. Neurol.

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ObjectiveNeuropsychiatric comorbidities are common among patients with mesial temporal lobe epilepsy (MTLE). One of these comorbidities, impulsivity, can significantly impact the quality of life and prognosis. However, there have been few studies of impulsivity in these patients, and the existing findings are inconsistent. The present study investigates impulsivity in MTLE patients from the perspective of inhibitory control and its underlying processes using event-related potentials (ERPs) initiated using a Go/NoGo task.MethodsA total of 25 MTLE patients and 25 age-, gender-, and education-matched healthy controls (HCs) completed an unequal visual Go/NoGo task. Different waveforms as well as behavioral measures were analyzed between Go and NoGo conditions (N2d and P3d). Impulsivity was also assessed using self -rating scales, and clinical variables that may be related to ERPs were explored.ResultsCompared with HCs, MTLE patients exhibited significantly longer reaction time (RT) (p = 0.002) and lower P3d especially at the frontal electrode sites (p = 0.001). In the MTLE group, the seizure frequency (p = 0.045) and seizure types (p < 0.001) were correlated with the P3d amplitude. A self-rated impulsivity assessment revealed that MTLE patients had higher non-planning (p = 0.017) and total scores (p = 0.019) on the BIS-11 as well as higher DI (p = 0.010) and lower FI (p = 0.007) on the DII.ConclusionThe findings demonstrate that the presence of inhibitory control deficits in patients with MTLE are characterized by deficits in the late stage of inhibition control, namely the motor inhibition stage. This study improves our understanding of impulsivity in MTLE patients and suggests that ERPs may constitute a sensitive means of detecting this trait.

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Impulsiveness, personality traits and executive functioning in patients with juvenile myoclonic epilepsy

Cited by 16 publications

References 49 publications

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions

Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets

Inhibitory control deficits in patients with mesial temporal lobe epilepsy: an event-related potential analysis based on Go/NoGo task

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