Impulsive Personality Traits Mediate the Relationship Between Adult Attention‐Deficit/Hyperactivity Symptoms and Alcohol Dependence Severity

Daurio, Allison M; Aston, Sean A.; Schwandt, Melanie L.; Bukhari, Mohammad O.; Bouhlal, Sofia; Farokhnia, Mehdi; Lee, Mary R.; Leggio, Lorenzo

doi:10.1111/acer.13538

Cited by 22 publications

(30 citation statements)

References 50 publications

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“…Negative urgency has also been linked to the higher prevalence of comorbid AUD in adults with attention-deficit/hyperactivity disorder (ADHD; Daurio et al, 2018). In a study of 794 adult subjects, different components of impulsivity were tested to understand the relationship between ADHD symptoms and the severity of alcohol dependence.…”

Section: Negative Urgency and Addiction: Tobacco Alcohol Cocaine Pmentioning

confidence: 99%

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency

Zorrilla

Koob

2019

Front. Behav. Neurosci.

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Negative urgency is a unique dimension of impulsivity that involves acting rashly when in extreme distress and impairments in inhibitory control. It has been hypothesized to derive from stress that is related to negative emotional states that are experienced during the withdrawal/negative affect stage of the addiction cycle. Classically, a transition to compulsive drug use prevents or relieves negative emotional states that result from abstinence or stressful environmental circumstances. Recent work suggests that this shift to the “dark side” is also implicated in impulsive use that derives from negative urgency. Stress and anxious, depressed, and irritable mood have high comorbidity with addiction. They may trigger bouts of drug seeking in humans via both negative reinforcement and negative urgency. The neurocircuitry that has been identified in the “dark side” of addiction involves key neuropeptides in the central extended amygdala, including corticotropin-releasing factor. The present review article summarizes empirical and conceptual advances in the field to understand the role of the “dark side” in driving the risky and detrimental substance use that is associated with negative urgency in addiction.

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Section: Negative Urgency and Addiction: Tobacco Alcohol Cocaine Pmentioning

confidence: 99%

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency

Zorrilla

Koob

2019

Front. Behav. Neurosci.

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“…A recent large study reported that symptoms of hyperactivity/restlessness and problems with self-concept increased the odds of having a diagnosis of ADHD and that impulsivity mediated the relationship between adult ADHD symptoms and alcohol dependence severity [40]. A Dutch study showed higher levels of motor and cognitive impulsivity in ADHD patients with comorbid cocaine dependence compared to ADHD patients without cocaine dependence and controls [41].…”

Section: Prevalence and Symptom Severitymentioning

confidence: 99%

Adult Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder: A Systematic Review of the Literature

Ilješ¹

2021

ADHD - From Etiology to Comorbidity

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Attention-deficit and hyperactivity disorder (ADHD) often presents with comorbid substance use disorder (SUD). The extant literature on the comorbidity of adult ADHD and SUD was summarized on the etiology, prevalence, diagnosis, and treatment. ADHD is diagnosed in 15-20% of SUD patients, mostly as ADHD with a combined presentation. ADHD and SUD are believed to have shared pathophysiology. ADHD is associated with the majority of dependence diagnoses. A most used screening questionnaire for screening ADHD patients presenting with SUD is the Adult ADHD Self-report Scale (ARSR). Evidence on pharmacological treatment is limited, but new trials support the use of long-acting stimulants as also recommended with a combination of psychotherapy by expert opinion. Given the prevalence of both ADHD and SUD, more research is needed to understand the theoretical and clinical implications of this comorbidity.

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“…It is worth to notice that children with ADHD are signi icantly more likely to develop substance use disorders than children without ADHD [8][9][10]. Indeed, previous studies have already shown that ADHD is a risk factor for the onset and the development of addiction to substances, like alcohol and drugs [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of alcohol dependence with attention-deficit/hyperactivity disorder and the role of executive dysfunctions

Tosi¹,

Vittadini²,

Giorgi³

et al. 2018

J Neurosci Neurol Disord

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Impulsive Personality Traits Mediate the Relationship Between Adult Attention‐Deficit/Hyperactivity Symptoms and Alcohol Dependence Severity

Cited by 22 publications

References 50 publications

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency

Adult Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder: A Systematic Review of the Literature

Comorbidity of alcohol dependence with attention-deficit/hyperactivity disorder and the role of executive dysfunctions

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