Impulsive Choice and Psychological Pain in Acutely Suicidal Depressed Patients

Cáceda, Ricardo; Durand, Dante; Cortes, Edmi; Prendes-Alvarez, Stefania; Moskovciak, Tori; Harvey, Philip D.; Nemeroff, Charles B.

doi:10.1097/psy.0000000000000075

Cited by 80 publications

(60 citation statements)

References 47 publications

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“…Because the study included participants who represented a range of depression levels, we compared psychological pain in our sample with scores reported for healthy adults and adults diagnosed with a depressive episode. The average level of psychological pain (PS = 40.60; OMMP_c = 122.03; OMMP_w = 179.26) was not significantly different from outpatients who experienced a major depressive episode, who scored 40.0 on the PS (Li et al, 2013; Xie et al, 2013), and was slightly lower than was found in patients admitted for a depressive episode, with a PS score of 46.06 and OMMP_c of 135.00 (Cáceda et al., 2014; van Heeringen et al, 2010). Psychological pain was significantly higher compared to healthy adults, who scored between 13.70 and 20.60 on the PS (Cáceda et al, 2014; Xie et al, 2013).…”

Section: Resultsmentioning

confidence: 66%

Resting-state EEG delta power is associated with psychological pain in adults with a history of depression

Meerwijk

Ford

Weiss

2015

Biological Psychology

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Psychological pain is a prominent symptom of clinical depression. We asked if frontal alpha asymmetry, frontal EEG power, and frontal fractal dimension asymmetry predicted psychological pain in adults with a history of depression. Resting-state frontal EEG (F3/F4) was recorded while participants (N=35) sat upright with their eyes closed. Frontal delta power predicted psychological pain while controlling for depressive symptoms, with participants who exhibited less power experiencing greater psychological pain. Frontal fractal dimension asymmetry, a nonlinear measure of complexity, also predicted psychological pain, such that greater left than right complexity was associated with greater psychological pain. Frontal alpha asymmetry did not contribute unique variance to any regression model of psychological pain. As resting-state delta power is associated with the brain’s default mode network, results suggest that the default mode network was less activated during high psychological pain. Findings are consistent with a state of arousal associated with psychological pain.

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Section: Resultsmentioning

confidence: 66%

Resting-state EEG delta power is associated with psychological pain in adults with a history of depression

Meerwijk

Ford

Weiss

2015

Biological Psychology

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“…Furthermore, suicide attempters that jumped off heights showed a trend toward lower testosterone levels without increases in luteinizing hormone, suggestive of dysfunction at the hypothalamus-pituitary level [64]. Lastly, suicidal ideation has been associated with cognitive abnormalities including executive function deficits [65] and increased impulsive choice [66]. The potential gender specific role of these cognitive factors in suicidal thinking and their influence on prosocial behavior will need to be further elucidated.…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Effects of Depression and Suicidal Ideation in Prosocial Behaviors

et al. 2014

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BackgroundProsocial behaviors are essential to the ability to relate to others. Women typically display greater prosocial behavior than men. The impact of depression on prosocial behaviors and how gender interacts with those effects are not fully understood. We explored the role of gender in the potential effects of depression on prosocial behavior.MethodsWe examined prosocial behaviors using a modified version of the Trust Game in a clinical population and community controls. Study participants were characterized on the severity of depression and anxiety, presence of suicidal ideation, history of childhood trauma, recent stressful life events, and impulsivity. We correlated behavioral outcomes with gender and clinical variables using analysis of variance and multiple regression analysis.ResultsThe 89 participants comprised four study groups: depressed women, depressed men, healthy women and healthy men (n = 16–36). Depressed men exhibited reciprocity more frequently than healthy men. Depression induced an inversion of the gender-specific pattern of self-centered behavior. Suicidal ideation was associated with increased reciprocity behavior in both genders, and enhancement of the effect of depression on gender-specific self-centered behavior.ConclusionsDepression, particularly suicidal ideation, is associated with reversal of gender-specific patterns of prosocial behavior, suggesting abnormalities in sexual hormones regulation. This explanation is supported by known abnormalities in the hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axes found in depression.

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“…Using this same scale in a population of depressed patients, some of whom reported suicidal ideation and some of whom had made an attempt, Cáceda et al (38) also found that psychic pain predicted suicidal ideation in the overall sample and differentiated the suicide attempters from the suicidal ideation group.…”

Section: Measuring Psychic Painmentioning

confidence: 92%

Addressing Patients’ Psychic Pain

Yager¹

2015

AJP

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Impulsive Choice and Psychological Pain in Acutely Suicidal Depressed Patients

Abstract: Transient impulsive choice abnormalities are found in a subset of those who attempt suicide. Both, suicidal ideation and behavior were associated with choice impulsivity and intense psychological pain.

Cited by 80 publications

References 47 publications

Resting-state EEG delta power is associated with psychological pain in adults with a history of depression

Resting-state EEG delta power is associated with psychological pain in adults with a history of depression

Gender-Specific Effects of Depression and Suicidal Ideation in Prosocial Behaviors

Addressing Patients’ Psychic Pain

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