Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants

Garlovsky, Jack; Simpson, Jane; Grünewald, Richard A.; Overton, Paul G.

doi:10.1080/08870446.2016.1218879

Cited by 13 publications

(27 citation statements)

References 81 publications

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“…Interestingly, beyond biomedical factors (dopaminergic treatments), psychological determinants (negative coping strategy, illness identity, and psychological distress) have also been related to ICDs and related behaviors. 47 Similarly, we could speculate that the same factors would lead to the dissociation between objective and historical UDysRS scores only in clinical significant ICDs and related behaviors patients. Specific research including nondyskinetic PD is needed to address this question.…”

Section: Discussionmentioning

confidence: 96%

“…We found similar objective UDysRS subscores among ICDs and related behaviors subgroups, indicating that additional factors modulate this relationship. Interestingly, beyond biomedical factors (dopaminergic treatments), psychological determinants (negative coping strategy, illness identity, and psychological distress) have also been related to ICDs and related behaviors . Similarly, we could speculate that the same factors would lead to the dissociation between objective and historical UDysRS scores only in clinical significant ICDs and related behaviors patients.…”

Section: Discussionmentioning

confidence: 97%

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Impulse control disorders in advanced Parkinson's disease with dyskinesia: The ALTHEA study

et al. 2017

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More than half of Parkinson's disease patients with dyskinesia have impulse control disorders and related behaviors, which are frequently clinically significant. Dopaminergic therapy total dose is associated with their severity. Clinicians should carefully assess patients with maladaptive behaviors and dyskinesia because they do not properly evaluate their motor and nonmotor status. © 2017 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Impulse control disorders in advanced Parkinson's disease with dyskinesia: The ALTHEA study

et al. 2017

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“…Efforts to identify the contribution of each factor for a specific ICD in PD showed that drug-induced mania, the use of DAs, early-onset of motor symptoms, severe depression and anxiety are risk factors for the development of gambling disorder 33 . Male sex, psychotic symptoms, dyskinesias and early onset of motor symptoms are associated with hypersexuality 11,17,36,39 . Female sex and obesity are correlated with binge eating 11,14 .…”

Section: Risk Factorsmentioning

confidence: 99%

“…Patients with PD and ICD tend to be described as shy with poor social skills, low self-esteem, beliefs based on a more negative perception of the disease, dysfunctional coping and paranoid ideation 39 .…”

Section: Neuropsychological Aspectsmentioning

confidence: 99%

“…Factors associated with punding and hobbyism include impulsivity, low disease-related quality of life, younger age at onset of PD, male sex, insomnia, smoking, substance abuse, anxiety, psychotic symptoms, collectionism, lascivious behavior and dyskinesia 16,39 . Punding and related behaviors are more severe among patients with juvenile PD due to mutation in the parkin gene 44 .…”

Section: Pundingmentioning

confidence: 99%

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Impulse control and related disorders in Parkinson’s disease

Vargas¹,

Cardoso

2018

Arq. Neuro-Psiquiatr.

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Neuropsychiatric disorders are common among patients with Parkinson's disease and may appear in any stage of the disease. However, these disorders often go undiagnosed and receive insufficient treatment. Observations in recent years have revealed that dopamine replacement therapy may lead to the development or worsening of conditions, such as gambling disorder, compulsive sexual behavior, compulsive buying and binge eating, in addition to punding and dopamine dysregulation syndrome. The pathophysiology of these disorders seems to be related to abnormal dopaminergic stimulation of the basal regions of the basal ganglia, especially via nigro-mesolimbic pathways. The aim of the present study was to perform a literature review on impulsivity, impulse control disorders and related conditions among patients with Parkinson's disease, with emphasis on their epidemiology, clinical characteristics and treatment.

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Does the Country Make a Difference in Impulse Control Disorders? A Systematic Review

Parra‐Díaz

Chico‐García

Beltrán‐Corbellini

et al. 2020

Movement Disord Clin Pract

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Background Background: Impulse control disorders (ICDs) have an increased frequency in patients with Parkinson's disease (PD), mainly because of treatment with dopamine agonists (DA). Factors related with the country of origin (culture, economy, healthcare politics) may impact phenomenology. Objectives Objectives: To explore phenomenology of ICDs depending on the country. Methods Methods: A systematic review following PRISMA guidelines was performed using Pubmed database. Articles published up to 2018 in which the prevalence of ICDs was analyzed were selected. Results Results: Thirty-two studies from 22 countries worldwide were included. The highest prevalence of ICDs in each continent was found in UK (59%), USA (39.1%) and India (31.6%). Frequency of ICDs was higher in those studies with lower mean age, higher proportion of males, whenever a screening instrument was used and whenever prescription of DAs was more common. Prevalence of ICDs was higher in Western countries compared to Asian countries (20.8% vs. 12.8%, P < 0.001) as it was the proportion of patients treated with DAs (66% vs. 48.2%, P < 0.001). Hypersexuality was the most common ICD overall (up to 23.8%). The highest frequencies of compulsive buying and eating were found in Western countries. Gambling was less commonly diagnosed, but prevalence was relevant Japan (14%). Conclusion Conclusion: We observed a tendency towards a different ICD profile in different geographical areas, which may be attributable to socio-economical, cultural or political influences in the phenomenology of these disorders. Acknowledging these differences could help their early detection, which is critical for prognosis.

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Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants

Cited by 13 publications

References 81 publications

Impulse control disorders in advanced Parkinson's disease with dyskinesia: The ALTHEA study

Impulse control disorders in advanced Parkinson's disease with dyskinesia: The ALTHEA study

Impulse control and related disorders in Parkinson’s disease

Does the Country Make a Difference in Impulse Control Disorders? A Systematic Review

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