Impulse control disorders and related behaviors in Indian patients with Parkinson's disease

Sarathchandran, Pournamy; Soman, Sheena; Sarma, Gangadhara; Krishnan, Syam; Kishore, DM Asha

doi:10.1002/mds.25557

Cited by 28 publications

(38 citation statements)

References 7 publications

(6 reference statements)

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“…The prevalence of ICRDs in PD was reported by different studies in different population, ranging from3.5% to 42.8% [2, 3]. These studies showed many factors may play a role in the risk of ICRDs in PD patients, including the use of dopamine agonists (DA), male gender, young patient, depression, smoking, drug abuse, genetic factors, family history of ICRDs and so on [4–6].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of impulse control and related disorders in Chinese Parkinson’s disease patients

Lin

Chen

et al. 2017

BMC Neurol

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BackgroundImpulse control and related disorders (ICRDs) are clinically complications in Parkinson’s disease (PD). However, the clinical characteristics of ICRDs in Chinese PD patients were rarely reported. We aimed to explore the prevalence and the clinical profile of ICRDs in Chinese patients with PD.Methods142 Chinese PD patients were consecutively enrolled. The symptoms of ICRDs were assessed with the Questionnaire for Impulsive-Compulsive Disorders. The clinical characteristics of patients with ICRDs and without ICRDs were compared.ResultsICRDs were present in 31% of our patients. The most common ICRDs were compulsive medication use (11.3%) and punding (9.2%); the least frequent were walkabout (1.4%). Variables independently associated with ICRDs were earlier onset of the disease (≤55 years), severe cognitive impairment (MMSE 10–20), the dose of dopamine agonist (>1 mg/d) and dyskinesia.ConclusionsICRDs was commonly found in Chinese PD patients. Earlier onset of the disease, the dose of dopamine agonist, severe cognitive impairment and dyskinesia are independent factors associated with ICRDs. Our results will be benefit for clinicians to assess the risk of developing ICRDs before delivering dopaminergic medication.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics of impulse control and related disorders in Chinese Parkinson’s disease patients

Lin

Chen

et al. 2017

BMC Neurol

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“…We reported earlier a cohort of 305 PD patients attending the movement disorder clinic of a University hospital, who were screened for the presence of ICD and subsequently, underwent direct, structured psychiatric interview for establishing the diagnosis [3]. In that cohort, patients whose treatment had been modified following the development of ICD were excluded as the study aimed to identify risk factors for ICD and ICRB [3].…”

Section: Methodsmentioning

confidence: 99%

“…In that cohort, patients whose treatment had been modified following the development of ICD were excluded as the study aimed to identify risk factors for ICD and ICRB [3]. For the present study, we recruited from this original cohort, all PD patients with one or more of the classical ICDs i.e., compulsive buying, eating, gambling and sexual behaviour (ICDþ) and 100 PD patients without ICD (ICD-).…”

Section: Methodsmentioning

confidence: 99%

“…Several hospital-based studies, using different survey methods, have reported a prevalence of ICD and related behaviours of 2e35%. [2,3]. Compulsive buying, eating, shopping and sexual behaviours are the common ICDs that occur significantly higher in PD patients than in healthy population [1].…”

Section: Introductionmentioning

confidence: 99%

“…Compulsive buying, eating, shopping and sexual behaviours are the common ICDs that occur significantly higher in PD patients than in healthy population [1]. Punding, hobbyism, walk-about and dopamine dysregulation syndrome are the other impulsive-compulsive behaviours reported in PD [1,3]. Several studies have shown that dopaminergic treatment, particularly dopamine agonist use, confers risk for the development of ICD, though PD by itself does not [4,5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson’s disease patients

Krishnamoorthy

Rajan

Banerjee

et al. 2016

Parkinsonism & Related Disorders

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Dopamine Receptor D3 rs6280 is Associated with Aberrant Decision‐Making in Parkinson's Disease

Rajan

Krishnan

Sarma

et al. 2018

Movement Disord Clin Pract

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Background The functional Ser9Gly single nucleotide polymorphism (SNP) in the dopamine D3 receptor gene is associated with impulse control disorders (ICD) in Parkinson's disease (PD) in Indian patients. Whether the same SNP modulates impulsivity in PD patients without active ICD is unknown. We aimed to compare decision‐making under uncertainty in PD patients with DRD3 p.S9G (rs6280) variants CT/CC or TT. Methods We conducted a cross‐sectional study including PD patients (n = 78) whose DRD3 p.S9G (rs6280) genotypic status was known (CC, CT, and TT). Decision‐making was assessed using the Iowa Gambling Task (IGT). Results IGT total (p = 0.267) or block scores did not differ between the DRD3 rs6280 variant groups. Deck choice analysis revealed that the CT/CC group showed a skewed preference in deck choice (p = 0.002) due to significantly fewer draws from deck B, compared to all other decks (deck A, p < 0.001; deck C, p = 0.004; deck D, p = 0.002). Conclusions The functional Ser9Gly DRD3 variant is associated with aberrant decision‐making under uncertainty in PD patients without active ICD. This ability to modulate impulsivity may underlie its association with clinical ICD in PD.

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Impulse control disorders and related behaviors in Indian patients with Parkinson's disease

Cited by 28 publications

References 7 publications

Clinical characteristics of impulse control and related disorders in Chinese Parkinson’s disease patients

Clinical characteristics of impulse control and related disorders in Chinese Parkinson’s disease patients

Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson’s disease patients

Dopamine Receptor D3 rs6280 is Associated with Aberrant Decision‐Making in Parkinson's Disease

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