2017
DOI: 10.1111/pbi.12749
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Improving zinc accumulation in cereal endosperm using HvMTP1, a transition metal transporter

Abstract: SummaryZinc (Zn) is essential for all life forms, including humans. It is estimated that around two billion people are deficient in their Zn intake. Human dietary Zn intake relies heavily on plants, which in many developing countries consists mainly of cereals. The inner part of cereal grain, the endosperm, is the part that is eaten after milling but contains only a quarter of the total grain Zn. Here, we present results demonstrating that endosperm Zn content can be enhanced through expression of a transporte… Show more

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Cited by 60 publications
(34 citation statements)
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“…For example, expression of the barley Metal Tolerance Protein 1 ( HvMTP1 ), under the control of a starchy endosperm‐specific promoter, significantly increased the zinc content in the endosperm of barley grains (Menguer et al . ), while expression of a wheat Vacuolar Iron Transporter ( TaVIT2 ) using a similar promoter more than doubled the iron content of the white flour fraction (Connorton et al . ).…”
Section: Transgenic Strategies To Increase Bioavailable Forms Of Ironmentioning
confidence: 99%
See 1 more Smart Citation
“…For example, expression of the barley Metal Tolerance Protein 1 ( HvMTP1 ), under the control of a starchy endosperm‐specific promoter, significantly increased the zinc content in the endosperm of barley grains (Menguer et al . ), while expression of a wheat Vacuolar Iron Transporter ( TaVIT2 ) using a similar promoter more than doubled the iron content of the white flour fraction (Connorton et al . ).…”
Section: Transgenic Strategies To Increase Bioavailable Forms Of Ironmentioning
confidence: 99%
“…By contrast, redirecting minerals into the starchy endosperm cells by overexpressing metal transporter genes leads to increases in single minerals, due to the high specificity of metal transporters, unless several genes are overexpressed together. For example, expression of the barley Metal Tolerance Protein 1 (HvMTP1), under the control of a starchy endospermspecific promoter, significantly increased the zinc content in the endosperm of barley grains (Menguer et al 2018), while expression of a wheat Vacuolar Iron Transporter (TaVIT2) using a similar promoter more than doubled the iron content of the white flour fraction (Connorton et al 2017b). This is illustrated in Fig.…”
Section: Transgenic Strategies To Increase Bioavailable Forms Of Ironmentioning
confidence: 99%
“…Considering the costs required for Zn fertilization, achieving Zn enrichment through root enhancement, as described here, presents a cost-effective and sustainable strategy contributing to genetic biofortification, which could be used in a complementary manner with other efforts (Borrill et al, 2014). In another transgenic approach, endosperm-specific expression of the Zn transporter gene METAL TOLERANCE PROTEIN1 doubled Zn accumulation in the endosperm of barley plants, which was most likely conferred by enhanced vacuolar Zn loading (Menguer et al, 2018). Future studies should reveal the molecular mechanism(s) underlying Zn biofortification in CKX transgenic plants and also study the tissue localization and chemical speciation of Zn, which affect Zn bioavailability for human consumption.…”
Section: Transgenic Plants Contain Higher Levels Of Free Amino Acidmentioning
confidence: 99%
“…Zn deficiency is common in humans as well as in plants. During the last decade, numerous attempts have been made to improve Zn concentration, such as increasing the expression of genes encoding metal transporters and metal chelators (Lee et al, 2009;Slametloedin et al, 2015;Menguer et al, 2018). However, engineering Zn content in staple crops is challenging because it involves many processes, from mineral uptake by the roots to transport throughout the plant, and accumulation in edible tissues (Palmer & Guerinot, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Micronutrient malnutrition, the so-called hidden hunger, affects more than half of the world's population, predominantly pregnant women and children in developing countries (Mayer et al, 2008). Currently, around two billion people worldwide suffer from nutritional deficiency of zinc (Zn), because their plantbased diets are not a sufficient source of this essential element (Prasad, 2012;Menguer et al, 2018). Deficiency of Zn raises the risk of growth stunting, infections, and even death (Mayer et al, 2008).…”
Section: Introductionmentioning
confidence: 99%