Improving Weight Loss by Combination of Two Temporary Antiobesity Treatments

Genco, Alfredo; Ienca, Roberta; Ernesti, Ilaria; Maselli, Roberta; Casella, Giovanni; Bresciani, Sabrina; Mariani, Stefania; Soricelli, Emanuele; Baglìo, Giovanni; Lorenzo, Michele; Monti, Massimo

doi:10.1007/s11695-018-3448-9

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…Recently, that relationship was demonstrated in an article published by Genco et al, reporting on a randomized sample of patients using NIBs but divided into two different dietetic groups. Patients on a low-calorie, high-protein diet achieved 11% more excess weight loss than the other group (35) .…”

Section: Discussionmentioning

confidence: 87%

Assessment of Weight Loss After Non-Adjustable and Adjustable Intragastric Balloon Use

Schwaab

Usuy

Albuquerque

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: Intragastric balloon (IGB) use is indicated for patients whose BMI precludes the option of bariatric surgery or who need to lose weight prior to undergoing surgery. It is a minimally invasive procedure and currently there are two main models of IGBs in use, the non-adjustable intragastric balloon (NIB), implanted for six months, and the adjustable intragastric balloon (AIB), implanted for up to 12 months. OBJECTIVE: Analyze clinical characteristics between patients receiving non-adjustable gastric balloon and the adjustable (prolonged implantation) intragastric balloon. METHODS: This was a cross-sectional study of 470 patients diagnosed as obese or overweight who had balloon implantation from October 2011 to July 2018. The associations between percentage excess weight loss versus clinical and demographic variables were calculated using the chi-squared test. Independent samples were submitted to the Student’s t test to determine the quantitative variables, with a confidence interval of 95%. Calculation of excess weight was based on an estimated ideal weight that would correspond to a BMI of 24.99 kg/m2. RESULTS: A total of 414 patients completed the treatment achieving an average total body weight loss (%TBWL) of 15.4±7 with the NIB and 15.5±9.6 with the AIB. Overweight patients achieved higher excess weight loss (%EWL) values using AIBs (157.2±82.5) and obese patients did so with NIB use (56±29.7). Women achieved higher %EWL values (65.6±62.2) than men (48±27.1). Individuals who attended >4 consultations with a nutritionist (60.8%) achieved TBWL >18%. All of those P-values were <0.001. CONCLUSION: Obese individuals and women registered the greatest weight losses. Overweight patients achieved greater losses using AIB and obese patients did so using NIBs. NIB use was associated with higher EWL percentages. Nutritional accompaniment had a positive impact on the %TBWL.

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Section: Discussionmentioning

confidence: 87%

Assessment of Weight Loss After Non-Adjustable and Adjustable Intragastric Balloon Use

Schwaab

Usuy

Albuquerque

et al. 2020

Arq. Gastroenterol.

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“…Intragastric balloon (IGB) therapy is a less invasive and more cost-effective option for the treatment of obesity than surgery (10)(11)(12)(13)(14)(15)(16). The presence of an IGB delays gastric emptying, causing a premature sensation of satiety and resulting in decreased food consumption (10).…”

Section: Introductionmentioning

confidence: 99%

“…The presence of an IGB delays gastric emptying, causing a premature sensation of satiety and resulting in decreased food consumption (10). IGB therapy becomes even more effective in combination with strict diet therapy (11).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Weight Loss Effect between a Low-carbohydrate Diet and a Calorie-restricted Diet in Combination with Intragastric Balloon Therapy

2020

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Objective Intragastric balloon (IGB) therapy is a low-invasion treatment for obesity. Recently, a lowcarbohydrate diet has shown effectiveness for encouraging weight loss, but whether or not a low-carbohydrate diet improves the efficacy of IGB therapy remains unclear. Therefore, we examined the effectiveness of a low-carbohydrate diet compared with a calorie-restricted diet in combination with IGB therapy. Methods A prospective study was conducted on 51 patients who had undergone IGB therapy from October 2012 to December 2017. Overall, 31 of the 51 patients were included in this study (12-month assessment after IGB placement). These 31 cases consisted of 18 IGB plus low-carbohydrate diet and 13 IGB plus calorierestricted diet. We compared the two groups with respect to body weight loss as outcomes. Results At 12 months after IGB placement, the body weight was significantly lower than that observed at baseline in both the IGB plus low-carbohydrate diet group (baseline 101.9±25.8 kg, 12 months 88.2±21.9 kg) (p<0.0001) and the IGB plus calorie-restricted diet group (baseline 103.5±17.0 kg, 12 months 89.1±6.2 kg) (p<0.005). The percentage of excess weight loss in the IGB plus low-carbohydrate diet group was slightly higher than that in the IGB plus calorie-restricted diet group, but there was no significant difference between the 2 groups at 12 months after IGB placement (IGB plus low-carbohydrate 49.9±60.0%, IGB plus calorierestricted diet 33.1±27.0%). ConclusionOur study demonstrated that both a low-carbohydrate diet and a calorie-restricted diet were effective interventions for weight reduction in combination with IGB therapy.

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“…Among 16 published controlled clinical trials with more than 25 subjects for parallel design, or fewer than 15 subjects for crossover design, total cholesterol decreased in one study [ 90 ], increased in one study [ 53 ], and did not change in other 6 studies [ 91 – 96 ]. High-density lipoprotein cholesterol increased in 4 out of 12.…”

Section: Safety and Common Side Effects Of Ketogenic Therapiesmentioning

confidence: 99%

The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review

Dalai

Ford

2022

J Psychiatry Brain Sci

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In search of interventions targeting brain dysfunction and underlying cognitive impairment in schizophrenia, we look at the brain and beyond to the potential role of dysfunctional systemic metabolism on neural network instability and insulin resistance in serious mental illness. We note that disrupted insulin and cerebral glucose metabolism are seen even in medication-naïve first-episode schizophrenia, suggesting that people with schizophrenia are at risk for Type 2 diabetes and cardiovascular disease, resulting in a shortened life span. Although glucose is the brain’s default fuel, ketones are a more efficient fuel for the brain. We highlight evidence that a ketogenic diet can improve both the metabolic and neural stability profiles. Specifically, a ketogenic diet improves mitochondrial metabolism, neurotransmitter function, oxidative stress/inflammation, while also increasing neural network stability and cognitive function. To reverse the neurodegenerative process, increasing the brain’s access to ketone bodies may be needed. We describe evidence that metabolic, neuroprotective, and neurochemical benefits of a ketogenic diet potentially provide symptomatic relief to people with schizophrenia while also improving their cardiovascular or metabolic health. We review evidence for KD side effects and note that although high in fat it improves various cardiovascular and metabolic risk markers in overweight/obese individuals. We conclude by calling for controlled clinical trials to confirm or refute the findings from anecdotal and case reports to address the potential beneficial effects of the ketogenic diet in people with serious mental illness.

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Improving Weight Loss by Combination of Two Temporary Antiobesity Treatments

Abstract: This study clearly indicates the efficacy of the prescription of very low-calorie ketogenic diet improving the efficacy of intragastric balloon positioning.

Cited by 12 publications

References 27 publications

Assessment of Weight Loss After Non-Adjustable and Adjustable Intragastric Balloon Use

Assessment of Weight Loss After Non-Adjustable and Adjustable Intragastric Balloon Use

A Comparison of the Weight Loss Effect between a Low-carbohydrate Diet and a Calorie-restricted Diet in Combination with Intragastric Balloon Therapy

The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review

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