Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy

Mangala, Lingegowda S.; Wang, Hongyu; Jiang, Dahai; Wu, Sherry Y.; Somasunderam, Anoma; Volk, David E.; Lokesh, G.L.; Li, Xin; Pradeep, Sunila; Yang, Xianbin; Haemmerle, Monika; Rodríguez-Aguayo, Cristian; Nagaraja, Archana S.; Rupaimoole, Rajesha; Bayraktar, Emine; Bayraktar, Recep; Li, Li; Tanaka, Takemi; Hu, Wei; Ivan, Cristina; Gharpure, Kshipra M.; McGuire, Michael H.; Thiviyanathan, Varatharasa; Zhang, Xinna; Maiti, Sourindra N.; Bulayeva, Nataliya; Choi, Hyun-Jin; Dorniak, Piotr L.; Cooper, Laurence J.N.; Rosenblatt, Kevin P.; López-Berestein, Gabriel; Gorenstein, David G.; Sood, Anil K.

doi:10.1172/jci.insight.87754

Cited by 12 publications

(10 citation statements)

References 32 publications

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“…After discovering the role of miRNAs in cell–cell signaling and TME, targeting miRNAs as anticancer therapeutic strategy is becoming more realistic and promising. Several groups designed miRNA overexpression or inhibition systems as a therapeutic strategy, and this approach led to promising outcomes in vivo (Bayraktar et al ., 2017; Hydbring et al ., 2017; Mangala et al ., 2016). For instance, Mangala et al .…”

Section: Novel Mirna‐based Therapeutic Approachesmentioning

confidence: 99%

“…Silencing of these miRNAs leads to restoration of tight junction function and in turn decreases angiogenesis. To evaluate the in vivo biological effects of miR‐106b‐5p and miR‐30c‐5p silencing, they established an ovarian cancer orthotopic mouse model and found that miR‐106b‐5p inhibitor treatment resulted in 50% reduction in tumor growth, while miR‐30c‐5p inhibitor treatment resulted in ~25% reduction in tumor growth in ovarian cancer orthotopic mouse model (Mangala et al ., 2016). The combination of miRNA mimic or inhibitor delivery with chemotherapeutic drugs has recently been used to enhance the efficiency of treatment in several types of tumor.…”

Section: Novel Mirna‐based Therapeutic Approachesmentioning

confidence: 99%

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Cell‐to‐cell communication: microRNAs as hormones

2017

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Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell‐to‐cell communication within the tumor microenvironment. EVs’ components, such as proteins, noncoding RNAs [microRNAs (miRNAs), and long noncoding RNAs (lncRNAs)], messenger RNAs (mRNAs), DNA, and lipids, can mediate paracrine signaling in the tumor microenvironment. Recently, miRNAs encapsulated in secreted EVs have been identified in the extracellular space. Mature miRNAs that participate in intercellular communication are released from most cells, often within EVs, and disseminate through the extracellular fluid to reach remote target cells, including tumor cells, whose phenotypes they can influence by regulating mRNA and protein expression either as tumor suppressors or as oncogenes, depending on their targets. In this review, we discuss the roles of miRNAs in intercellular communication, the biological function of extracellular miRNAs, and their potential applications for diagnosis and therapeutics. We will give examples of miRNAs that behave as hormones.

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Section: Novel Mirna‐based Therapeutic Approachesmentioning

confidence: 99%

Section: Novel Mirna‐based Therapeutic Approachesmentioning

confidence: 99%

Cell‐to‐cell communication: microRNAs as hormones

2017

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“…Angiogenesis is crucial for tumor progression and metastasis. Mangala et al isolated endothelial cells from high-grade serous ovarian cancer and normal ovarian tissues and identified deregulated miRNAs in cancer-associated endothelial cells (64); they demonstrated that one of the deregulated miRNAs, miR-29a/c, was a regulator of VEGF. The downregulation of miR-29a/c was shown to promote GC progression by increasing VEGF expression (65).…”

Section: Role Of Mirnas In Regulating Tumor-associated Macrophagesmentioning

confidence: 99%

Role of microRNAs in remodeling the tumor microenvironment (Review)

et al. 2019

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MicroRNAs (miRNAs) are short non-coding RNAs that are known to regulate gene expression at the post-transcriptional level. miRNA expression is often deregulated in several human cancers, affecting the communication between tumor stroma and tumor cells, among other functions. Understanding the role of miRNAs in the tumor microenvironment is crucial for fully elucidating the molecular mechanisms underlying tumor progression and exploring novel diagnostic biomarkers and therapeutic targets. The present review focused on the role of miRNAs in remodeling the tumor microenvironment, with an emphasis on their impact on tumor growth, metastasis and resistance to treatment, as well as their potential clinical applications.

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“…In 2016, Mangala et al described the selection of thioaptamers targeting ovarian cancer-associated endothelial cells generated by using a thioaptamer version of the Cell-SELEX technique [ 155 ] against ovarian cancer associated-endothelial cells derived from ten different patients while using cells derived from normal ovaries as controls. They found that the Endo28 thioaptamer targets annexin A2, a protein upregulated in cancer [ 156 , 157 ].…”

Section: Thioaptamer Developmentmentioning

confidence: 99%

Development of Phosphorothioate DNA and DNA Thioaptamers

Volk

Lokesh

2017

Biomedicines

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Nucleic acid aptamers are short RNA- or DNA-based affinity reagents typically selected from combinatorial libraries to bind to a specific target such as a protein, a small molecule, whole cells or even animals. Aptamers have utility in the development of diagnostic, imaging and therapeutic applications due to their size, physico-chemical nature and ease of synthesis and modification to suit the application. A variety of oligonucleotide modifications have been used to enhance the stability of aptamers from nuclease degradation in vivo. The non-bridging oxygen atoms of the phosphodiester backbones of RNA and DNA aptamers can be substituted with one or two sulfur atoms, resulting in thioaptamers with phosphorothioate or phosphorodithioate linkages, respectively. Such thioaptamers are known to have increased binding affinity towards their target, as well as enhanced resistance to nuclease degradation. In this review, we discuss the development of phosphorothioate chemistry and thioaptamers, with a brief review of selection methods.

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Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy

Cited by 12 publications

References 32 publications

Cell‐to‐cell communication: microRNAs as hormones

Cell‐to‐cell communication: microRNAs as hormones

Role of microRNAs in remodeling the tumor microenvironment (Review)

Development of Phosphorothioate DNA and DNA Thioaptamers

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