Improving the visualisation of perforator arteries for anterolateral thigh flaps harvest in CT angiography via sublingual glyceryl trinitrate

Lü, Gang; Su, Yan; Jiang, Yongxiang; Liu, Yang; Wang, Yichuan; Shi, Guangming; Wang, Xianding; Duan, Xiaohui; Hu, Huan

doi:10.1016/j.crad.2023.07.004

Cited by 1 publication

(1 citation statement)

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“… 8 In another study assessing anterolateral thigh flap vascularization by CT angiography, sublingual glyceryl trinitrate resulted in increased lumen diameters of deep femoral artery, lateral circumflex femoral artery (LCFA), descending branch of LCFA and its perforators ( P < 0.01) and increased number and qualitative grade of visible perforators. 9 These findings suggest the preoperative utility of nitrates to increase vascular caliber for identification of perforators and surgical planning.…”

Section: Vasodilatory Properties Of Nitrates In Flapsmentioning

confidence: 88%

Nontopical Nitrates in Flap Perfusion and Delay Phenomenon

Izadpanah,

Jansen,

Chaffin

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Background: Topical nitrates have demonstrated efficacy in improving flap perfusion. However, evidence for nontopical nitrates in modulation of flap perfusion dynamics has yet to be consolidated. Here, we review evidence regarding the use of intravascular, sublingual, and oral nitrates in modulating flap perfusion. Methods: We performed a review of the literature for evidence linking nontopical nitrates and flap perfusion, and included clinical studies, animal studies, and in vitro studies. Results: Evidence suggests that intravascular, sublingual, and oral nitrates exert vasodilatory properties, which may be harnessed for identification of perforators and improved flap perfusion. We also found evidence suggesting nitrates may facilitate ischemic preconditioning while reducing ischemia–reperfusion injury. Conclusions: Nitrates delivered intravascularly, sublingually, or orally may increase flap perfusion and serve as a method for ischemic preconditioning, particularly in the intraoperative setting.

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Section: Vasodilatory Properties Of Nitrates In Flapsmentioning

confidence: 88%