Improving the Recognition of Hereditary Interstitial Kidney Disease

Bleyer, Anthony J.

doi:10.1681/asn.2007121330

Cited by 13 publications

(21 citation statements)

References 13 publications

(19 reference statements)

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“…In patient with renal failure, hyperuricemia is, behind the other, one of characteristic caused by impaired kidney function (20). Gout can be the consequence of hereditary interstitial kidney disease, because of renal failure which is caused with this hereditary disorder (21). …”

Section: Uric Acid Precipitation and Goutmentioning

confidence: 99%

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

Marinković²,

2012

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With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and diff erent disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a signifi cant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is signifi cantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an ''antioxidant'' , a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.

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Section: Uric Acid Precipitation and Goutmentioning

confidence: 99%

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

Marinković²,

2012

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“…Compared with children and older adults, young adults have the lowest rates of insurance coverage . Furthermore, adolescents and young adults with cancer are distinct because they have not experienced the same improvement in survival over the last 2 decades as their younger and older counterparts . The lack of improvement in outcomes may be due in part to limited access to care secondary to a lack of insurance coverage.…”

Section: Introductionmentioning

confidence: 99%

The Patient Protection and Affordable Care Act dependent coverage expansion: Disparities in impact among young adult oncology patients

Alvarez

Keegan

Johnston

et al. 2017

Cancer

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BACKGROUND Private health insurance is associated with improved outcomes in patients with cancer. However, to the authors' knowledge, little is known regarding the impact of the Patient Protection and Affordable Care Act Dependent Coverage Expansion (ACA‐DCE), which extended private insurance to young adults (to age 26 years) beginning in 2010, on the insurance status of young adults with cancer. METHODS The current study was a retrospective, population‐based analysis of hospitalized young adult oncology patients (aged 22‐30 years) in California during 2006 through 2014 (11,062 patients). Multivariable regression analyses examined factors associated with having private insurance. Results were presented as adjusted odds ratios and 95% confidence intervals. A difference‐in‐difference analysis examined the influence of the ACA‐DCE on insurance coverage by race/ethnicity and federal poverty level. RESULTS Multivariable regression demonstrated that patients of black and Hispanic race/ethnicity were less likely to have private insurance before and after the ACA‐DCE, compared with white patients. Younger age (22‐25 years) was associated with having private insurance after implementation of the ACA‐DCE (odds ratio, 1.20; 95% confidence interval, 1.06‐1.35). In the difference‐in‐difference analysis, private insurance increased among white patients aged 22 to 25 years who were living in medium‐income (2006‐2009: 64.6% vs 2011‐2014: 69.1%; P = .003) and high‐income (80.4% vs 82%; P = .043) zip codes and among Asians aged 22 to 25 years living in high‐income zip codes (73.2 vs 85.7%; P = .022). Private insurance decreased for all Hispanic patients aged 22 to 25 years between the 2 time periods. CONCLUSIONS The ACA‐DCE provision increased insurance coverage, but not among all patients. Private insurance increased for white and Asian patients in higher income neighborhoods, potentially widening social disparities in private insurance coverage among young adults with cancer. Cancer 2018;124:110‐7. © 2017 American Cancer Society.

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“…In contrast to ADPKD, MCKD is characterized by tubular interstitial fibrosis with normal to small sized kidneys usually accompanied by early hyperuricemia and gout. Medullary cysts may be detected in some individuals late in the course of disease but are frequently absent 37.…”

Section: Distinguishing Adpkd From Other Cystic Diseasesmentioning

confidence: 99%

Diagnosis and Screening of Autosomal Dominant Polycystic Kidney Disease

Pei

Watnick

2010

Advances in Chronic Kidney Disease

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Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and accounts for ∼5% of end-stage renal disease (ESRD) population in the United States. The disorder is characterized by the focal and sporadic development of renal cysts, which increase in size and number with age. Mutations of PKD1 and PKD2 account for most of the cases. Although the clinical manifestations of both gene types overlap completely, PKD1 is associated with more severe disease than PKD2, with larger kidneys and earlier onset of ESRD. In general, renal ultrasonography is commonly used for the diagnosis of ADPKD and age-dependent criteria have been defined for subjects at-risk of PKD1. However, the utility of the PKD1 ultrasound criteria in the clinic setting is unclear since their performance characteristics have not been defined for the milder PKD2 and the gene type for most test subjects is unknown. Recently, highly predictive ultrasound diagnostic criteria have been derived for at-risk subjects of unknown gene type. Additionally, both DNA linkage or gene-based direct sequencing are now available for the diagnosis of ADPKD, especially in subjects with equivocal imaging results, a negative or indeterminate family history, or in younger at-risk individuals being evaluated as potential living-related kidney donors. Here, we review the clinical utilities and limitations of both imaging-and molecular-based diagnostic tests, and outline our approach for the evaluation of individuals suspected to have ADPKD.

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Improving the Recognition of Hereditary Interstitial Kidney Disease

Cited by 13 publications

References 13 publications

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

The Patient Protection and Affordable Care Act dependent coverage expansion: Disparities in impact among young adult oncology patients

Diagnosis and Screening of Autosomal Dominant Polycystic Kidney Disease

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