This chapter reviews Operations Research models for strategic design of motor carrier networks, including network configuration and terminal location. This includes networks for less-than-truckload (LTL), truckload (TL), and postal motor carriers that serve many origins and destinations in large geographic regions. LTL carriers, as well as postal carriers, use networks with consolidation and break-bulk terminals to combine small shipments into efficient vehicle loads. Some TL carriers use networks with relay terminals where loads can be exchanged to allow drivers to return home more frequently. The chapter reviews research in each area and proposes directions for future research.