Improving the Preclinical Mouse Efficacy Studies of Adenomyosis

Guo, Sun‐Wei; Habiba, Marwan

doi:10.1007/978-3-319-13012-5_8

Cited by 1 publication

(2 citation statements)

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“…As has been previously noted, there is also a need for outcome measures in animal studies to match clinical priorities, as histological disease progression does not necessarily correlate with symptoms in women. 95 Moreover, increased use of in vivo transcriptomic and cistromic analyses in animal models would facilitate the identification of molecular pathways involved in disease pathogenesis or as therapeutic targets, and new genetic models would help pinpoint the molecular basis of disease development. Finally, increased integration of translational human studies with research in animal models would leverage the unique benefits of both systems and result in the best chance at new clinically relevant knowledge and treatment options to combat adenomyosis in women suffering from its effects.…”

Section: Resultsmentioning

confidence: 99%

“…Though not ideal substitutes for analyzing adenomyosis-associated pelvic pain, such experiments are reasonable given the possible association between adenomyosis and neuropathic pain or sensory gain. 95 ICR mice with tamoxifen-induced adenomyosis have been utilized extensively to study adenomyosis-related pain due to the well-established increase in generalized hyperalgesia in this model. [82][83][84][85][86]88,93 Treatment with antiplatelet therapy or a variety of drugs such as VPA, P4, l-THP, andrographolide, leonurine, EGCG, or resveratrol has been demonstrated to alleviate this adenomyosis-related pain sensitivity.…”

Section: Painmentioning

confidence: 99%

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Animal Models of Adenomyosis

2020

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Adenomyosis is a nonmalignant uterine disorder in which endometrial tissue exists within and grows into the myometrium. Animal models have generated limited insight into the still-unclear pathogenesis of adenomyosis, provided a platform for preclinical screening of many drugs and compounds with potential as therapeutics, and elucidated mechanisms underlying the pain and fertility issues that occur in many women with the disease. Spontaneous adenomyosis has been studied in nonhuman primates, primarily in the form of case reports. Adenomyosis is routinely experimentally induced in mice through methods such as neonatal tamoxifen exposure, pituitary engraftment, and human tissue xenotransplantation. Several studies have also reported hormonal or environmental toxicant exposures that give rise to murine adenomyosis, and genetically engineered models have been created that recapitulate the human-like condition, most notably involving alteration of β-catenin expression. This review describes the animal models for adenomyosis and their contributions to our understanding of the factors underpinning the development of symptoms. Animal models represent a unique opportunity for understanding the molecular basis of adenomyosis and developing efficacious treatment options for affected women. Herein, we assess their different potentials and limitations with regard to identification of new therapeutic interventions and reflect on future directions for research and drug validation.

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Section: Resultsmentioning

confidence: 99%