Improving the performance of silicon photonic rings, disks, and Bragg gratings for use in label-free biosensing

Schmidt, Shon; Flueckiger, Jonas; Wu, Wenxuan; Grist, Samantha M.; Fard, Sahba Talebi; Donzella, Valentina; Khumwan, Pakapreud; Thompson, Emily; Wang, Qian; Kulik, Pavel; Wang, Xu; Sherwali, Ahmed; Kirk, James T.; Cheung, Karen C.; Chrostowski, Lukas; Ratner, Daniel M.

doi:10.1117/12.2062389

Cited by 55 publications

(75 citation statements)

References 77 publications

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“…At this coupling length, the minimum iDL of 3.71 × 10 4 was achieved, which is 32.5% lower than the best value reported in SWG resonator sensor (5.5 × 10 4 RIU) [21]. The sensitivity of the SWGRTR is higher than that of TM mode strip waveguide ring resonators with waveguide thicknesses of 150 nm (247nm/RIU) and 220nm (238nm/RIU) [20].…”

Section: Device Tests and Resultsmentioning

confidence: 73%

“…3. The absorption loss caused by analytes in water can be suppressed by moving to a shorter wavelength operating at 1310 nm, and the devices would suffer about an order of magnitude less of the absorption loss [20]. The scattering loss can be further decreased if better fabrication condition is available to reduce the surface roughness of devices.…”

Section: Device Tests and Resultsmentioning

confidence: 99%

“…The bulk sensitivity (S) is ~429.7 nm/RIU (refractive index unit), and the enhanced intrinsic detection limit (iDL) of 3.71 × 10 4 RIU are achieved. The intrinsic detection limit is improved by 32.5% compared to the best value reported for SWG microring sensors [20,21]. A schematic of the proposed SWGRTR is shown in Fig.…”

Section: Introductionmentioning

confidence: 89%

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Improving the detection limit for on-chip photonic sensors based on subwavelength grating racetrack resonators

Huang¹,

Yan²,

Xu³

et al. 2017

Opt. Express

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Abstract:Compared to the conventional strip waveguide microring resonators, subwavelength grating (SWG) waveguide microring resonators have better sensitivity and lower detection limit due to the enhanced photon-analyte interaction. As sensors, especially biosensors, are usually used in absorptive ambient environment, it is very challenging to further improve the detection limit of the SWG ring resonator by simply increasing the sensitivity. The high sensitivity resulted from larger mode-analyte overlap also brings significant absorption loss, which deteriorates the quality factor of the resonator. To explore the potential of the SWG ring resonator, we theoretically and experimentally optimize an ultrasensitive transverse magnetic mode SWG racetrack resonator to obtain maximum quality factor and thus lowest detection limit. A quality factor of 9800 around 1550 nm and sensitivity of 429.7 ± 0.4nm/RIU in water environment are achieved. It corresponds to a detection limit (λ/S·Q) of 3.71 × 10 4 RIU, which marks a reduction of 32.5% compared to the best value reported for SWG microring sensors.

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Section: Device Tests and Resultsmentioning

confidence: 73%

Section: Device Tests and Resultsmentioning

confidence: 99%

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Improving the detection limit for on-chip photonic sensors based on subwavelength grating racetrack resonators

Huang¹,

Yan²,

Xu³

et al. 2017

Opt. Express

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show abstract

“…On the other hand, label-free detection technologies are rapidly evolving as alternative means for detecting a wide range of biomolecules in a simpler and more efficient way [31]. Among the different transduction technologies considered for these developments, planar integrated photonic technology presents advantages such as high sensitivity, compactness, high multiplexing level, shorter time to result, need of very low sample and reagent volumes, immunity to electromagnetic interferences and compatibility with CMOS (Complementary Metal-Oxide-Semiconductor) technology fabrication [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes

Ruiz-Tórtola

Prats-Quílez

González-Lucas

et al. 2018

Biomed. Opt. Express

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Abstract:A label-free sensor, based on the combination of silicon photonic bandgap (PBG) structures with immobilized molecular beacon (MB) probes, is experimentally developed. Complementary target oligonucleotides are specifically recognized through hybridization with the MB probes on the surface of the sensing structure. This combination of PBG sensing structures and MB probes demonstrates an extremely high sensitivity without the need for complex PCR-based amplification or labelling methods. correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis," Leukemia 21(5), 912-916 (2007). 4. R. L. Maute, C. Schneider, P. Sumazin, A. Holmes, A. Califano, K. Basso, and R. Dalla-Favera, "tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma," Proc. Natl. Acad. Sci. U.S.A. 110(4), 1404-1409 (2013). 5. L. P. Lim, N. C. Lau, P. Garrett-Engele, A. Grimson, J. M. Schelter, J. Castle, D. P. Bartel, P. S. Linsley, and J.M. Johnson, "Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs," Nature 433(7027), 769-773 (2005

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“…Among these, polymer surfaces have good biocompatibility and can be easily modified to immobilize a wide range of biomolecules, which is beneficial to achieve the label-free detection [18]. Additionally, most analytes are aqueous with a large optical absorption loss at the lightwave band of 1550 nm, which greatly deteriorates the performance of silicon on insulator based biosensors [19]. The polymer waveguides can work at the lightwave bands of 650 nm or 850 nm [20][21][22] where the aqueous analytes have a very low optical absorption loss [23].…”

Section: Introductionmentioning

confidence: 99%

Optimal design of 850 nm 2×2 multimode interference polymer waveguide coupler by imprint technique

Shao

Han

et al. 2016

Photonic Sens

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A 2×2 optical waveguide coupler at 850 nm based on the multimode interference (MMI) structure with the polysilsesquioxanes liquid series (PSQ-Ls) polymer material and the imprint technique is presented. The influence of the structural parameters, such as the single mode condition, the waveguide spacing of input/output ports, and the width and length of the multimode waveguide, on the optical splitting performance including the excess loss and the uniformity is simulated by the beam propagation method. By inserting a taper section of isosceles trapezoid between the single mode and multimode waveguides, the optimized structural parameters for low excess loss and high uniformity are obtained with the excess loss of -0.040 dB and the uniformity of -0.007 dB. The effect of the structure deviations induced during the imprint process on the optical splitting performance at different residual layer thicknesses is also investigated. The analysis results provide useful instructions for the waveguide device fabrication.

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Improving the performance of silicon photonic rings, disks, and Bragg gratings for use in label-free biosensing

Cited by 55 publications

References 77 publications

Improving the detection limit for on-chip photonic sensors based on subwavelength grating racetrack resonators

Improving the detection limit for on-chip photonic sensors based on subwavelength grating racetrack resonators

High sensitivity and label-free oligonucleotides detection using photonic bandgap sensing structures biofunctionalized with molecular beacon probes

Optimal design of 850 nm 2×2 multimode interference polymer waveguide coupler by imprint technique

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